9CAQ

Cryo-EM structure of a human MCM2-7 double hexamer formed from independently loaded MCM2-7 single hexamers

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
2	0000727	biological_process	double-strand break repair via break-induced replication
2	0000781	cellular_component	chromosome, telomeric region
2	0000785	cellular_component	chromatin
2	0003677	molecular_function	DNA binding
2	0003688	molecular_function	DNA replication origin binding
2	0003689	molecular_function	DNA clamp loader activity
2	0003697	molecular_function	single-stranded DNA binding
2	0004386	molecular_function	helicase activity
2	0005515	molecular_function	protein binding
2	0005524	molecular_function	ATP binding
2	0005634	cellular_component	nucleus
2	0005654	cellular_component	nucleoplasm
2	0005664	cellular_component	nuclear origin of replication recognition complex
2	0005694	cellular_component	chromosome
2	0005730	cellular_component	nucleolus
2	0005737	cellular_component	cytoplasm
2	0006260	biological_process	DNA replication
2	0006268	biological_process	DNA unwinding involved in DNA replication
2	0006270	biological_process	DNA replication initiation
2	0006334	biological_process	nucleosome assembly
2	0006915	biological_process	apoptotic process
2	0009378	molecular_function	four-way junction helicase activity
2	0016787	molecular_function	hydrolase activity
2	0016887	molecular_function	ATP hydrolysis activity
2	0017116	molecular_function	single-stranded DNA helicase activity
2	0019899	molecular_function	enzyme binding
2	0030174	biological_process	regulation of DNA-templated DNA replication initiation
2	0032508	biological_process	DNA duplex unwinding
2	0036121	molecular_function	double-stranded DNA helicase activity
2	0042393	molecular_function	histone binding
2	0042555	cellular_component	MCM complex
2	0043138	molecular_function	3'-5' DNA helicase activity
2	0046872	molecular_function	metal ion binding
2	0061749	molecular_function	forked DNA-dependent helicase activity
2	0061775	molecular_function	cohesin loader activity
2	0071162	cellular_component	CMG complex
2	0071353	biological_process	cellular response to interleukin-4
2	0090102	biological_process	cochlea development
2	0140584	molecular_function	chromatin extrusion motor activity
2	0140588	biological_process	chromatin looping
2	0140665	molecular_function	ATP-dependent H3-H4 histone complex chaperone activity
2	0140849	molecular_function	ATP-dependent H2AZ histone chaperone activity
2	1902975	biological_process	mitotic DNA replication initiation
2	1990518	molecular_function	single-stranded 3'-5' DNA helicase activity
3	0000727	biological_process	double-strand break repair via break-induced replication
3	0000781	cellular_component	chromosome, telomeric region
3	0003677	molecular_function	DNA binding
3	0003689	molecular_function	DNA clamp loader activity
3	0003697	molecular_function	single-stranded DNA binding
3	0004386	molecular_function	helicase activity
3	0005515	molecular_function	protein binding
3	0005524	molecular_function	ATP binding
3	0005634	cellular_component	nucleus
3	0005654	cellular_component	nucleoplasm
3	0005658	cellular_component	alpha DNA polymerase:primase complex
3	0005694	cellular_component	chromosome
3	0005730	cellular_component	nucleolus
3	0005737	cellular_component	cytoplasm
3	0005813	cellular_component	centrosome
3	0006260	biological_process	DNA replication
3	0006268	biological_process	DNA unwinding involved in DNA replication
3	0006270	biological_process	DNA replication initiation
3	0006271	biological_process	DNA strand elongation involved in DNA replication
3	0006338	biological_process	chromatin remodeling
3	0009378	molecular_function	four-way junction helicase activity
3	0016020	cellular_component	membrane
3	0016787	molecular_function	hydrolase activity
3	0016887	molecular_function	ATP hydrolysis activity
3	0017116	molecular_function	single-stranded DNA helicase activity
3	0030174	biological_process	regulation of DNA-templated DNA replication initiation
3	0032508	biological_process	DNA duplex unwinding
3	0036121	molecular_function	double-stranded DNA helicase activity
3	0042555	cellular_component	MCM complex
3	0048471	cellular_component	perinuclear region of cytoplasm
3	0061749	molecular_function	forked DNA-dependent helicase activity
3	0061775	molecular_function	cohesin loader activity
3	0071162	cellular_component	CMG complex
3	0140584	molecular_function	chromatin extrusion motor activity
3	0140588	biological_process	chromatin looping
3	0140665	molecular_function	ATP-dependent H3-H4 histone complex chaperone activity
3	0140849	molecular_function	ATP-dependent H2AZ histone chaperone activity
3	1902975	biological_process	mitotic DNA replication initiation
3	1990518	molecular_function	single-stranded 3'-5' DNA helicase activity
4	0000727	biological_process	double-strand break repair via break-induced replication
4	0000781	cellular_component	chromosome, telomeric region
4	0003677	molecular_function	DNA binding
4	0003678	molecular_function	DNA helicase activity
4	0003689	molecular_function	DNA clamp loader activity
4	0003697	molecular_function	single-stranded DNA binding
4	0004386	molecular_function	helicase activity
4	0005515	molecular_function	protein binding
4	0005524	molecular_function	ATP binding
4	0005634	cellular_component	nucleus
4	0005654	cellular_component	nucleoplasm
4	0005694	cellular_component	chromosome
4	0006260	biological_process	DNA replication
4	0006268	biological_process	DNA unwinding involved in DNA replication
4	0006271	biological_process	DNA strand elongation involved in DNA replication
4	0006338	biological_process	chromatin remodeling
4	0009378	molecular_function	four-way junction helicase activity
4	0016020	cellular_component	membrane
4	0016787	molecular_function	hydrolase activity
4	0016887	molecular_function	ATP hydrolysis activity
4	0017116	molecular_function	single-stranded DNA helicase activity
4	0030174	biological_process	regulation of DNA-templated DNA replication initiation
4	0032508	biological_process	DNA duplex unwinding
4	0036121	molecular_function	double-stranded DNA helicase activity
4	0042555	cellular_component	MCM complex
4	0061749	molecular_function	forked DNA-dependent helicase activity
4	0061775	molecular_function	cohesin loader activity
4	0071162	cellular_component	CMG complex
4	0140584	molecular_function	chromatin extrusion motor activity
4	0140588	biological_process	chromatin looping
4	0140665	molecular_function	ATP-dependent H3-H4 histone complex chaperone activity
4	0140849	molecular_function	ATP-dependent H2AZ histone chaperone activity
4	1902975	biological_process	mitotic DNA replication initiation
4	1990518	molecular_function	single-stranded 3'-5' DNA helicase activity
5	0000727	biological_process	double-strand break repair via break-induced replication
5	0000781	cellular_component	chromosome, telomeric region
5	0003677	molecular_function	DNA binding
5	0003689	molecular_function	DNA clamp loader activity
5	0003697	molecular_function	single-stranded DNA binding
5	0004386	molecular_function	helicase activity
5	0005515	molecular_function	protein binding
5	0005524	molecular_function	ATP binding
5	0005634	cellular_component	nucleus
5	0005654	cellular_component	nucleoplasm
5	0005694	cellular_component	chromosome
5	0006260	biological_process	DNA replication
5	0006261	biological_process	DNA-templated DNA replication
5	0006268	biological_process	DNA unwinding involved in DNA replication
5	0006270	biological_process	DNA replication initiation
5	0006338	biological_process	chromatin remodeling
5	0009378	molecular_function	four-way junction helicase activity
5	0016020	cellular_component	membrane
5	0016787	molecular_function	hydrolase activity
5	0016887	molecular_function	ATP hydrolysis activity
5	0017116	molecular_function	single-stranded DNA helicase activity
5	0030174	biological_process	regulation of DNA-templated DNA replication initiation
5	0032508	biological_process	DNA duplex unwinding
5	0036121	molecular_function	double-stranded DNA helicase activity
5	0042555	cellular_component	MCM complex
5	0043138	molecular_function	3'-5' DNA helicase activity
5	0061749	molecular_function	forked DNA-dependent helicase activity
5	0061775	molecular_function	cohesin loader activity
5	0071162	cellular_component	CMG complex
5	0140584	molecular_function	chromatin extrusion motor activity
5	0140588	biological_process	chromatin looping
5	0140665	molecular_function	ATP-dependent H3-H4 histone complex chaperone activity
5	0140849	molecular_function	ATP-dependent H2AZ histone chaperone activity
5	1990518	molecular_function	single-stranded 3'-5' DNA helicase activity
6	0000727	biological_process	double-strand break repair via break-induced replication
6	0000781	cellular_component	chromosome, telomeric region
6	0003677	molecular_function	DNA binding
6	0003678	molecular_function	DNA helicase activity
6	0003689	molecular_function	DNA clamp loader activity
6	0003697	molecular_function	single-stranded DNA binding
6	0004386	molecular_function	helicase activity
6	0005515	molecular_function	protein binding
6	0005524	molecular_function	ATP binding
6	0005634	cellular_component	nucleus
6	0005654	cellular_component	nucleoplasm
6	0005694	cellular_component	chromosome
6	0006260	biological_process	DNA replication
6	0006268	biological_process	DNA unwinding involved in DNA replication
6	0006338	biological_process	chromatin remodeling
6	0009378	molecular_function	four-way junction helicase activity
6	0016787	molecular_function	hydrolase activity
6	0016887	molecular_function	ATP hydrolysis activity
6	0030174	biological_process	regulation of DNA-templated DNA replication initiation
6	0032508	biological_process	DNA duplex unwinding
6	0036121	molecular_function	double-stranded DNA helicase activity
6	0042555	cellular_component	MCM complex
6	0042802	molecular_function	identical protein binding
6	0061749	molecular_function	forked DNA-dependent helicase activity
6	0061775	molecular_function	cohesin loader activity
6	0071162	cellular_component	CMG complex
6	0140584	molecular_function	chromatin extrusion motor activity
6	0140588	biological_process	chromatin looping
6	0140665	molecular_function	ATP-dependent H3-H4 histone complex chaperone activity
6	0140849	molecular_function	ATP-dependent H2AZ histone chaperone activity
6	1902969	biological_process	mitotic DNA replication
6	1990518	molecular_function	single-stranded 3'-5' DNA helicase activity
7	0000727	biological_process	double-strand break repair via break-induced replication
7	0000781	cellular_component	chromosome, telomeric region
7	0000785	cellular_component	chromatin
7	0003677	molecular_function	DNA binding
7	0003678	molecular_function	DNA helicase activity
7	0003689	molecular_function	DNA clamp loader activity
7	0003697	molecular_function	single-stranded DNA binding
7	0004386	molecular_function	helicase activity
7	0005515	molecular_function	protein binding
7	0005524	molecular_function	ATP binding
7	0005634	cellular_component	nucleus
7	0005654	cellular_component	nucleoplasm
7	0005694	cellular_component	chromosome
7	0005730	cellular_component	nucleolus
7	0005829	cellular_component	cytosol
7	0006260	biological_process	DNA replication
7	0006268	biological_process	DNA unwinding involved in DNA replication
7	0006270	biological_process	DNA replication initiation
7	0006271	biological_process	DNA strand elongation involved in DNA replication
7	0006338	biological_process	chromatin remodeling
7	0006974	biological_process	DNA damage response
7	0008283	biological_process	cell population proliferation
7	0009378	molecular_function	four-way junction helicase activity
7	0009410	biological_process	response to xenobiotic stimulus
7	0016020	cellular_component	membrane
7	0016787	molecular_function	hydrolase activity
7	0016887	molecular_function	ATP hydrolysis activity
7	0017116	molecular_function	single-stranded DNA helicase activity
7	0030174	biological_process	regulation of DNA-templated DNA replication initiation
7	0032508	biological_process	DNA duplex unwinding
7	0036121	molecular_function	double-stranded DNA helicase activity
7	0042325	biological_process	regulation of phosphorylation
7	0042555	cellular_component	MCM complex
7	0061749	molecular_function	forked DNA-dependent helicase activity
7	0061775	molecular_function	cohesin loader activity
7	0071162	cellular_component	CMG complex
7	0071364	biological_process	cellular response to epidermal growth factor stimulus
7	0071466	biological_process	cellular response to xenobiotic stimulus
7	0140584	molecular_function	chromatin extrusion motor activity
7	0140588	biological_process	chromatin looping
7	0140665	molecular_function	ATP-dependent H3-H4 histone complex chaperone activity
7	0140849	molecular_function	ATP-dependent H2AZ histone chaperone activity
7	1990518	molecular_function	single-stranded 3'-5' DNA helicase activity
A	0000727	biological_process	double-strand break repair via break-induced replication
A	0000781	cellular_component	chromosome, telomeric region
A	0000785	cellular_component	chromatin
A	0003677	molecular_function	DNA binding
A	0003688	molecular_function	DNA replication origin binding
A	0003689	molecular_function	DNA clamp loader activity
A	0003697	molecular_function	single-stranded DNA binding
A	0004386	molecular_function	helicase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005664	cellular_component	nuclear origin of replication recognition complex
A	0005694	cellular_component	chromosome
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0006260	biological_process	DNA replication
A	0006268	biological_process	DNA unwinding involved in DNA replication
A	0006270	biological_process	DNA replication initiation
A	0006334	biological_process	nucleosome assembly
A	0006915	biological_process	apoptotic process
A	0009378	molecular_function	four-way junction helicase activity
A	0016787	molecular_function	hydrolase activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0017116	molecular_function	single-stranded DNA helicase activity
A	0019899	molecular_function	enzyme binding
A	0030174	biological_process	regulation of DNA-templated DNA replication initiation
A	0032508	biological_process	DNA duplex unwinding
A	0036121	molecular_function	double-stranded DNA helicase activity
A	0042393	molecular_function	histone binding
A	0042555	cellular_component	MCM complex
A	0043138	molecular_function	3'-5' DNA helicase activity
A	0046872	molecular_function	metal ion binding
A	0061749	molecular_function	forked DNA-dependent helicase activity
A	0061775	molecular_function	cohesin loader activity
A	0071162	cellular_component	CMG complex
A	0071353	biological_process	cellular response to interleukin-4
A	0090102	biological_process	cochlea development
A	0140584	molecular_function	chromatin extrusion motor activity
A	0140588	biological_process	chromatin looping
A	0140665	molecular_function	ATP-dependent H3-H4 histone complex chaperone activity
A	0140849	molecular_function	ATP-dependent H2AZ histone chaperone activity
A	1902975	biological_process	mitotic DNA replication initiation
A	1990518	molecular_function	single-stranded 3'-5' DNA helicase activity
B	0000727	biological_process	double-strand break repair via break-induced replication
B	0000781	cellular_component	chromosome, telomeric region
B	0003677	molecular_function	DNA binding
B	0003689	molecular_function	DNA clamp loader activity
B	0003697	molecular_function	single-stranded DNA binding
B	0004386	molecular_function	helicase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005658	cellular_component	alpha DNA polymerase:primase complex
B	0005694	cellular_component	chromosome
B	0005730	cellular_component	nucleolus
B	0005737	cellular_component	cytoplasm
B	0005813	cellular_component	centrosome
B	0006260	biological_process	DNA replication
B	0006268	biological_process	DNA unwinding involved in DNA replication
B	0006270	biological_process	DNA replication initiation
B	0006271	biological_process	DNA strand elongation involved in DNA replication
B	0006338	biological_process	chromatin remodeling
B	0009378	molecular_function	four-way junction helicase activity
B	0016020	cellular_component	membrane
B	0016787	molecular_function	hydrolase activity
B	0016887	molecular_function	ATP hydrolysis activity
B	0017116	molecular_function	single-stranded DNA helicase activity
B	0030174	biological_process	regulation of DNA-templated DNA replication initiation
B	0032508	biological_process	DNA duplex unwinding
B	0036121	molecular_function	double-stranded DNA helicase activity
B	0042555	cellular_component	MCM complex
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0061749	molecular_function	forked DNA-dependent helicase activity
B	0061775	molecular_function	cohesin loader activity
B	0071162	cellular_component	CMG complex
B	0140584	molecular_function	chromatin extrusion motor activity
B	0140588	biological_process	chromatin looping
B	0140665	molecular_function	ATP-dependent H3-H4 histone complex chaperone activity
B	0140849	molecular_function	ATP-dependent H2AZ histone chaperone activity
B	1902975	biological_process	mitotic DNA replication initiation
B	1990518	molecular_function	single-stranded 3'-5' DNA helicase activity
C	0000727	biological_process	double-strand break repair via break-induced replication
C	0000781	cellular_component	chromosome, telomeric region
C	0003677	molecular_function	DNA binding
C	0003678	molecular_function	DNA helicase activity
C	0003689	molecular_function	DNA clamp loader activity
C	0003697	molecular_function	single-stranded DNA binding
C	0004386	molecular_function	helicase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005694	cellular_component	chromosome
C	0006260	biological_process	DNA replication
C	0006268	biological_process	DNA unwinding involved in DNA replication
C	0006271	biological_process	DNA strand elongation involved in DNA replication
C	0006338	biological_process	chromatin remodeling
C	0009378	molecular_function	four-way junction helicase activity
C	0016020	cellular_component	membrane
C	0016787	molecular_function	hydrolase activity
C	0016887	molecular_function	ATP hydrolysis activity
C	0017116	molecular_function	single-stranded DNA helicase activity
C	0030174	biological_process	regulation of DNA-templated DNA replication initiation
C	0032508	biological_process	DNA duplex unwinding
C	0036121	molecular_function	double-stranded DNA helicase activity
C	0042555	cellular_component	MCM complex
C	0061749	molecular_function	forked DNA-dependent helicase activity
C	0061775	molecular_function	cohesin loader activity
C	0071162	cellular_component	CMG complex
C	0140584	molecular_function	chromatin extrusion motor activity
C	0140588	biological_process	chromatin looping
C	0140665	molecular_function	ATP-dependent H3-H4 histone complex chaperone activity
C	0140849	molecular_function	ATP-dependent H2AZ histone chaperone activity
C	1902975	biological_process	mitotic DNA replication initiation
C	1990518	molecular_function	single-stranded 3'-5' DNA helicase activity
D	0000727	biological_process	double-strand break repair via break-induced replication
D	0000781	cellular_component	chromosome, telomeric region
D	0003677	molecular_function	DNA binding
D	0003689	molecular_function	DNA clamp loader activity
D	0003697	molecular_function	single-stranded DNA binding
D	0004386	molecular_function	helicase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005694	cellular_component	chromosome
D	0006260	biological_process	DNA replication
D	0006261	biological_process	DNA-templated DNA replication
D	0006268	biological_process	DNA unwinding involved in DNA replication
D	0006270	biological_process	DNA replication initiation
D	0006338	biological_process	chromatin remodeling
D	0009378	molecular_function	four-way junction helicase activity
D	0016020	cellular_component	membrane
D	0016787	molecular_function	hydrolase activity
D	0016887	molecular_function	ATP hydrolysis activity
D	0017116	molecular_function	single-stranded DNA helicase activity
D	0030174	biological_process	regulation of DNA-templated DNA replication initiation
D	0032508	biological_process	DNA duplex unwinding
D	0036121	molecular_function	double-stranded DNA helicase activity
D	0042555	cellular_component	MCM complex
D	0043138	molecular_function	3'-5' DNA helicase activity
D	0061749	molecular_function	forked DNA-dependent helicase activity
D	0061775	molecular_function	cohesin loader activity
D	0071162	cellular_component	CMG complex
D	0140584	molecular_function	chromatin extrusion motor activity
D	0140588	biological_process	chromatin looping
D	0140665	molecular_function	ATP-dependent H3-H4 histone complex chaperone activity
D	0140849	molecular_function	ATP-dependent H2AZ histone chaperone activity
D	1990518	molecular_function	single-stranded 3'-5' DNA helicase activity
E	0000727	biological_process	double-strand break repair via break-induced replication
E	0000781	cellular_component	chromosome, telomeric region
E	0003677	molecular_function	DNA binding
E	0003678	molecular_function	DNA helicase activity
E	0003689	molecular_function	DNA clamp loader activity
E	0003697	molecular_function	single-stranded DNA binding
E	0004386	molecular_function	helicase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005694	cellular_component	chromosome
E	0006260	biological_process	DNA replication
E	0006268	biological_process	DNA unwinding involved in DNA replication
E	0006338	biological_process	chromatin remodeling
E	0009378	molecular_function	four-way junction helicase activity
E	0016787	molecular_function	hydrolase activity
E	0016887	molecular_function	ATP hydrolysis activity
E	0030174	biological_process	regulation of DNA-templated DNA replication initiation
E	0032508	biological_process	DNA duplex unwinding
E	0036121	molecular_function	double-stranded DNA helicase activity
E	0042555	cellular_component	MCM complex
E	0042802	molecular_function	identical protein binding
E	0061749	molecular_function	forked DNA-dependent helicase activity
E	0061775	molecular_function	cohesin loader activity
E	0071162	cellular_component	CMG complex
E	0140584	molecular_function	chromatin extrusion motor activity
E	0140588	biological_process	chromatin looping
E	0140665	molecular_function	ATP-dependent H3-H4 histone complex chaperone activity
E	0140849	molecular_function	ATP-dependent H2AZ histone chaperone activity
E	1902969	biological_process	mitotic DNA replication
E	1990518	molecular_function	single-stranded 3'-5' DNA helicase activity
F	0000727	biological_process	double-strand break repair via break-induced replication
F	0000781	cellular_component	chromosome, telomeric region
F	0000785	cellular_component	chromatin
F	0003677	molecular_function	DNA binding
F	0003678	molecular_function	DNA helicase activity
F	0003689	molecular_function	DNA clamp loader activity
F	0003697	molecular_function	single-stranded DNA binding
F	0004386	molecular_function	helicase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005694	cellular_component	chromosome
F	0005730	cellular_component	nucleolus
F	0005829	cellular_component	cytosol
F	0006260	biological_process	DNA replication
F	0006268	biological_process	DNA unwinding involved in DNA replication
F	0006270	biological_process	DNA replication initiation
F	0006271	biological_process	DNA strand elongation involved in DNA replication
F	0006338	biological_process	chromatin remodeling
F	0006974	biological_process	DNA damage response
F	0008283	biological_process	cell population proliferation
F	0009378	molecular_function	four-way junction helicase activity
F	0009410	biological_process	response to xenobiotic stimulus
F	0016020	cellular_component	membrane
F	0016787	molecular_function	hydrolase activity
F	0016887	molecular_function	ATP hydrolysis activity
F	0017116	molecular_function	single-stranded DNA helicase activity
F	0030174	biological_process	regulation of DNA-templated DNA replication initiation
F	0032508	biological_process	DNA duplex unwinding
F	0036121	molecular_function	double-stranded DNA helicase activity
F	0042325	biological_process	regulation of phosphorylation
F	0042555	cellular_component	MCM complex
F	0061749	molecular_function	forked DNA-dependent helicase activity
F	0061775	molecular_function	cohesin loader activity
F	0071162	cellular_component	CMG complex
F	0071364	biological_process	cellular response to epidermal growth factor stimulus
F	0071466	biological_process	cellular response to xenobiotic stimulus
F	0140584	molecular_function	chromatin extrusion motor activity
F	0140588	biological_process	chromatin looping
F	0140665	molecular_function	ATP-dependent H3-H4 histone complex chaperone activity
F	0140849	molecular_function	ATP-dependent H2AZ histone chaperone activity
F	1990518	molecular_function	single-stranded 3'-5' DNA helicase activity

Functional Information from PROSITE/UniProt

site_id	PS00847
Number of Residues	9
Details	MCM_1 MCM family signature. GVVCIDEFD

Chain	Residue	Details
3	GLY404-ASP412
5	GLY440-ASP448
2	GLY582-ASP590
6	GLY455-ASP463
4	GLY569-ASP577
7	GLY440-ASP448

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	BINDING: BINDING => ECO:0000305|PubMed:32453425, ECO:0007744|PDB:6XTX

Chain	Residue	Details
7	TYR345
F	GLY384
F	ALA386
F	LYS387
F	SER388
F	ASN489
F	ARG514
F	ARG604
E	ARG619
E	GLU622
7	GLY384
7	ALA386
7	LYS387
7	SER388
7	ASN489
7	ARG514
7	ARG604
F	TYR345

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: N-acetylalanine => ECO:0000269|Ref.7, ECO:0007744|PubMed:22223895

Chain	Residue	Details
7	ALA2
F	ALA2
A	SER530
A	GLN531

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
7	SER121
F	SER121
D	SER315
D	SER605

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
7	SER314
7	SER678
F	SER314
F	SER678
D	LYS396
D	LYS696

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231

Chain	Residue	Details
7	SER365
F	SER365
E	SER271
E	SER762

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
7	SER500
F	SER500

---

site_id	SWS_FT_FI7
Number of Residues	6
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
7	LYS15
E	LYS643
7	LYS28
F	LYS15
F	LYS28

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P97311

Chain	Residue	Details
6	SER689
E	SER689

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:17525332

Chain	Residue	Details
6	THR791
E	THR791
C	THR102
C	THR110

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
4	SER105
C	SER105

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
4	SER120
C	SER120

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
4	SER131
C	SER131

---

site_id	SWS_FT_FI13
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231

Chain	Residue	Details
4	SER142
4	SER145
C	SER142
C	SER145

---

site_id	SWS_FT_FI14
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
4	LYS220
4	LYS450
C	LYS220
C	LYS450

---

site_id	SWS_FT_FI15
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P49717

Chain	Residue	Details
4	LYS858
C	LYS858

---

site_id	SWS_FT_FI16
Number of Residues	6
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
4	LYS439
3	SER734
4	LYS798
C	LYS439
C	LYS798

---

site_id	SWS_FT_FI17
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:16899510, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
2	SER139
A	SER139

---

site_id	SWS_FT_FI18
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
2	LYS216
A	LYS216

---

site_id	SWS_FT_FI19
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692

Chain	Residue	Details
2	SER381
A	SER381

---

site_id	SWS_FT_FI20
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
2	LYS178
A	LYS178

---