9CAF
Cryo-EM structure of the reconstituted TRRAP lobe of the human TIP60 complex (composite structure)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | E1A-binding protein p400,Haloalkane dehalogenase chimera | polymer | 1122 | 125783.7 | 1 | UniProt (Q96L91) UniProt (P0A3G4) Pfam (PF07529) Pfam (PF00561) | Homo sapiens (human) | |
| 2 | B (D) | Isoform 2 of Transformation/transcription domain-associated protein | polymer | 3811 | 433231.3 | 1 | UniProt (Q9Y4A5) Pfam (PF20175) Pfam (PF20206) Pfam (PF02259) Pfam (PF00454) | Homo sapiens (human) | 350/400 kDa PCAF-associated factor,PAF350/400,STAF40,Tra1 homolog |
| 3 | C (D) | INOSITOL HEXAKISPHOSPHATE | non-polymer | 660.0 | 1 | Chemie (IHP) |
Sequence modifications
A: 1731 - 2131 (UniProt: Q96L91)
A: 2134 - 2530 (UniProt: Q96L91)
A: 2550 - 2837 (UniProt: P0A3G4)
D: 1 - 3830 (UniProt: Q9Y4A5)
A: 2134 - 2530 (UniProt: Q96L91)
| PDB | External Database | Details |
|---|---|---|
| Pro 2132 | - | linker |
| Gly 2133 | - | linker |
| Asp 2364 | - | insertion |
| - | Gly 2435 | deletion |
| Leu 2443 | - | insertion |
| - | Ser 2476 | deletion |
| Pro 2492 | - | insertion |
| Asp 2531 | - | linker |
| Gly 2532 | - | linker |
| Ser 2533 | - | linker |
| Gly 2534 | - | linker |
| Gly 2535 | - | linker |
| Ser 2536 | - | linker |
| Gly 2537 | - | linker |
| Glu 2538 | - | linker |
| Asp 2539 | - | linker |
| Leu 2540 | - | linker |
| Tyr 2541 | - | linker |
| Phe 2542 | - | linker |
| Gln 2543 | - | linker |
| Ser 2544 | - | linker |
| Gly 2545 | - | linker |
| Gly 2546 | - | linker |
| Ser 2547 | - | linker |
| Met 2548 | - | linker |
| Ala 2549 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Val 2594 | Leu 47 | conflict |
| Thr 2605 | Ser 58 | conflict |
| Gly 2625 | Asp 78 | conflict |
| Phe 2634 | Tyr 87 | conflict |
| Met 2635 | Leu 88 | conflict |
| Phe 2675 | Cys 128 | conflict |
| Thr 2702 | Ala 155 | conflict |
| Lys 2707 | Glu 160 | conflict |
| Val 2714 | Ala 167 | conflict |
| Thr 2719 | Ala 172 | conflict |
| Met 2722 | Lys 175 | conflict |
| Gly 2723 | Cys 176 | conflict |
| Asn 2742 | Lys 195 | conflict |
| Glu 2771 | Ala 224 | conflict |
| Asp 2774 | Asn 227 | conflict |
| Lys 2804 | Glu 257 | conflict |
| Ala 2811 | Thr 264 | conflict |
| Asn 2819 | His 272 | conflict |
| Leu 2820 | Tyr 273 | conflict |
| Ser 2838 | - | expression tag |
| Thr 2839 | - | expression tag |
| Leu 2840 | - | expression tag |
| Glu 2841 | - | expression tag |
| Ile 2842 | - | expression tag |
| Ser 2843 | - | expression tag |
| Gly 2844 | - | expression tag |
| Gly 2845 | - | expression tag |
| Gly 2846 | - | expression tag |
| His 2847 | - | expression tag |
| His 2848 | - | expression tag |
| His 2849 | - | expression tag |
| His 2850 | - | expression tag |
| His 2851 | - | expression tag |
| His 2852 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser 521 | Val 487 | conflict |
| Gly 522 | Pro 488 | conflict |
| Gly 523 | Thr 489 | conflict |
| Gly 524 | Ala 490 | conflict |
| Ala 525 | Pro 491 | conflict |
| Ser 526 | Ala 492 | conflict |
| Gly 527 | Ala 493 | conflict |
| Gly 528 | Pro 494 | conflict |
| - | Pro 496 | deletion |
| - | Ala 497 | deletion |
| - | Pro 498 | deletion |
| - | Ser 499 | deletion |
| - | Pro 500 | deletion |
| - | Ala 501 | deletion |
| - | Pro 502 | deletion |
| - | Val 503 | deletion |
| - | Pro 504 | deletion |
| - | Ala 505 | deletion |
| - | Pro 506 | deletion |
| - | Pro 507 | deletion |
| - | Pro 508 | deletion |
| - | Pro 509 | deletion |
| - | Pro 510 | deletion |
| - | Pro 511 | deletion |
| - | Pro 512 | deletion |
| - | Pro 513 | deletion |
| - | Pro 514 | deletion |
| - | Pro 515 | deletion |
| - | Ala 516 | deletion |
| - | Thr 517 | deletion |
| - | Pro 518 | deletion |
| - | Val 519 | deletion |
| - | Thr 520 | deletion |
| - | Pro 521 | deletion |
| - | Ala 522 | deletion |
| - | Pro 523 | deletion |
| - | Val 524 | deletion |
| - | Pro 525 | deletion |
| - | Pro 526 | deletion |
| - | Phe 527 | deletion |
| - | Glu 528 | deletion |
| - | Lys 529 | deletion |
| Ser 530 | Gln 530 | conflict |
| Gly 2007 | - | insertion |
| Asp 2007 | - | insertion |
| Tyr 2007 | - | insertion |
| Lys 2007 | - | insertion |
| Asp 2007 | - | insertion |
| His 2007 | - | insertion |
| Asp 2007 | - | insertion |
| Ile 2007 | - | insertion |
| Asp 2007 | - | insertion |
| Tyr 2007 | - | insertion |
| Lys 2007 | - | insertion |
| Asp 2007 | - | insertion |
| Asp 2007 | - | insertion |
| Asp 2008 | - | insertion |
| Asp 2008 | - | insertion |
| Lys 2008 | Val 2021 | conflict |
| Gly 2008 | Asn 2022 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 559015.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 660.0 | |
| All* | Total formula weight | 559675.0 |
