9C9M
HIV-1 intasome core bound with DTG
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, F, G, K... (A, B, I, K, L...) | Integrase | polymer | 358 | 39864.6 | 6 | UniProt (P12497) Pfam (PF02022) Pfam (PF00665) Pfam (PF00552) | Human immunodeficiency virus 1 | IN |
| 2 | C, H (D, M) | Integrase | polymer | 106 | 12101.9 | 2 | UniProt (P12497) Pfam (PF00552) | Human immunodeficiency virus 1 | IN |
| 3 | D, I (E, N) | viral DNA | polymer | 27 | 8188.3 | 2 | Human immunodeficiency virus 1 | ||
| 4 | E, J (F, O) | vDNA | polymer | 25 | 7773.0 | 2 | Human immunodeficiency virus 1 | ||
| 5 | M, N, Q, R (A, I) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 6 | O, S (A, I) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 7 | P, T (F, O) | (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide | non-polymer | 419.4 | 2 | Chemie (DLU) | |||
| 8 | AA, BA, CA, DA, EA... (K, M, N, O, L...) | water | water | 18.0 | 81 | Chemie (HOH) |
Sequence modifications
A, B, I, K, L, C: 1 - 288 (UniProt: P12497)
D, M: 185 - 288 (UniProt: P12497)
| PDB | External Database | Details |
|---|---|---|
| Met -69 | - | initiating methionine |
| Ala -68 | - | expression tag |
| Thr -67 | - | expression tag |
| Val -66 | - | expression tag |
| Lys -65 | - | expression tag |
| Phe -64 | - | expression tag |
| Lys -63 | - | expression tag |
| Tyr -62 | - | expression tag |
| Lys -61 | - | expression tag |
| Gly -60 | - | expression tag |
| Glu -59 | - | expression tag |
| Glu -58 | - | expression tag |
| Lys -57 | - | expression tag |
| Glu -56 | - | expression tag |
| Val -55 | - | expression tag |
| Asp -54 | - | expression tag |
| Ile -53 | - | expression tag |
| Ser -52 | - | expression tag |
| Lys -51 | - | expression tag |
| Ile -50 | - | expression tag |
| Lys -49 | - | expression tag |
| Lys -48 | - | expression tag |
| Val -47 | - | expression tag |
| Trp -46 | - | expression tag |
| Arg -45 | - | expression tag |
| Val -44 | - | expression tag |
| Gly -43 | - | expression tag |
| Lys -42 | - | expression tag |
| Met -41 | - | expression tag |
| Ile -40 | - | expression tag |
| Ser -39 | - | expression tag |
| Phe -38 | - | expression tag |
| Thr -37 | - | expression tag |
| Tyr -36 | - | expression tag |
| Asp -35 | - | expression tag |
| Glu -34 | - | expression tag |
| Gly -33 | - | expression tag |
| Gly -32 | - | expression tag |
| Gly -31 | - | expression tag |
| Lys -30 | - | expression tag |
| Thr -29 | - | expression tag |
| Gly -28 | - | expression tag |
| Arg -27 | - | expression tag |
| Gly -26 | - | expression tag |
| Ala -25 | - | expression tag |
| Val -24 | - | expression tag |
| Ser -23 | - | expression tag |
| Glu -22 | - | expression tag |
| Lys -21 | - | expression tag |
| Asp -20 | - | expression tag |
| Ala -19 | - | expression tag |
| Pro -18 | - | expression tag |
| Lys -17 | - | expression tag |
| Glu -16 | - | expression tag |
| Leu -15 | - | expression tag |
| Leu -14 | - | expression tag |
| Gln -13 | - | expression tag |
| Met -12 | - | expression tag |
| Leu -11 | - | expression tag |
| Glu -10 | - | expression tag |
| Lys -9 | - | expression tag |
| Gln -8 | - | expression tag |
| Lys -7 | - | expression tag |
| Lys -6 | - | expression tag |
| Gly -5 | - | expression tag |
| Gly -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Gly 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| His 183 | - | expression tag |
| Met 184 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 295314.2 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1066.8 | |
| All* | Total formula weight | 296381.0 |
