9C9M

HIV-1 intasome core bound with DTG

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, I, K, L...	Integrase	polymer	358	39864.6	6	UniProt (P12497) In PDB	Human immunodeficiency virus 1	IN
2	D, M	Integrase	polymer	106	12101.9	2	UniProt (P12497) In PDB	Human immunodeficiency virus 1	IN
3	E, N	viral DNA	polymer	27	8188.3	2		Human immunodeficiency virus 1
4	F, O	vDNA	polymer	25	7773.0	2		Human immunodeficiency virus 1
5	A, I	MAGNESIUM ION	non-polymer		24.3	4	Chemie (MG)
6	A, I	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
7	F, O	(4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide	non-polymer		419.4	2	Chemie (DLU)
8		water	water		18.0	81	Chemie (HOH)

Sequence modifications

A, B, I, K, L, C: 1 - 288 (UniProt: P12497)

PDB	External Database	Details
Met -69	-	initiating methionine
Ala -68	-	expression tag
Thr -67	-	expression tag
Val -66	-	expression tag
Lys -65	-	expression tag
Phe -64	-	expression tag
Lys -63	-	expression tag
Tyr -62	-	expression tag
Lys -61	-	expression tag
Gly -60	-	expression tag
Glu -59	-	expression tag
Glu -58	-	expression tag
Lys -57	-	expression tag
Glu -56	-	expression tag
Val -55	-	expression tag
Asp -54	-	expression tag
Ile -53	-	expression tag
Ser -52	-	expression tag
Lys -51	-	expression tag
Ile -50	-	expression tag
Lys -49	-	expression tag
Lys -48	-	expression tag
Val -47	-	expression tag
Trp -46	-	expression tag
Arg -45	-	expression tag
Val -44	-	expression tag
Gly -43	-	expression tag
Lys -42	-	expression tag
Met -41	-	expression tag
Ile -40	-	expression tag
Ser -39	-	expression tag
Phe -38	-	expression tag
Thr -37	-	expression tag
Tyr -36	-	expression tag
Asp -35	-	expression tag
Glu -34	-	expression tag
Gly -33	-	expression tag
Gly -32	-	expression tag
Gly -31	-	expression tag
Lys -30	-	expression tag
Thr -29	-	expression tag
Gly -28	-	expression tag
Arg -27	-	expression tag
Gly -26	-	expression tag
Ala -25	-	expression tag
Val -24	-	expression tag
Ser -23	-	expression tag
Glu -22	-	expression tag
Lys -21	-	expression tag
Asp -20	-	expression tag
Ala -19	-	expression tag
Pro -18	-	expression tag
Lys -17	-	expression tag
Glu -16	-	expression tag
Leu -15	-	expression tag
Leu -14	-	expression tag
Gln -13	-	expression tag
Met -12	-	expression tag
Leu -11	-	expression tag
Glu -10	-	expression tag
Lys -9	-	expression tag
Gln -8	-	expression tag
Lys -7	-	expression tag
Lys -6	-	expression tag
Gly -5	-	expression tag
Gly -4	-	expression tag
Gly -3	-	expression tag
Gly -2	-	expression tag
Gly -1	-	expression tag
Gly 0	-	expression tag

D, M: 185 - 288 (UniProt: P12497)

PDB	External Database	Details
His 183	-	expression tag
Met 184	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	295314.2
Non-Polymers*	Number of molecules	8
	Total formula weight	1066.8
All*	Total formula weight	296381.0

*Water molecules are not included.