9C9M
HIV-1 intasome core bound with DTG
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0004521 | molecular_function | RNA endonuclease activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0015074 | biological_process | DNA integration |
| B | 0003676 | molecular_function | nucleic acid binding |
| B | 0003677 | molecular_function | DNA binding |
| B | 0004521 | molecular_function | RNA endonuclease activity |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0015074 | biological_process | DNA integration |
| C | 0003676 | molecular_function | nucleic acid binding |
| C | 0003677 | molecular_function | DNA binding |
| C | 0004521 | molecular_function | RNA endonuclease activity |
| C | 0008270 | molecular_function | zinc ion binding |
| C | 0015074 | biological_process | DNA integration |
| D | 0003676 | molecular_function | nucleic acid binding |
| I | 0003676 | molecular_function | nucleic acid binding |
| I | 0003677 | molecular_function | DNA binding |
| I | 0004521 | molecular_function | RNA endonuclease activity |
| I | 0008270 | molecular_function | zinc ion binding |
| I | 0015074 | biological_process | DNA integration |
| K | 0003676 | molecular_function | nucleic acid binding |
| K | 0003677 | molecular_function | DNA binding |
| K | 0004521 | molecular_function | RNA endonuclease activity |
| K | 0008270 | molecular_function | zinc ion binding |
| K | 0015074 | biological_process | DNA integration |
| L | 0003676 | molecular_function | nucleic acid binding |
| L | 0003677 | molecular_function | DNA binding |
| L | 0004521 | molecular_function | RNA endonuclease activity |
| L | 0008270 | molecular_function | zinc ion binding |
| L | 0015074 | biological_process | DNA integration |
| M | 0003676 | molecular_function | nucleic acid binding |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 94 |
| Details | DNA_BIND: Integrase-type => ECO:0000255|PROSITE-ProRule:PRU00506 |
| Chain | Residue | Details |
| D | PHE223-ASP270 | |
| M | PHE223-ASP270 | |
| I | ASP3-GLN44 | |
| K | ASP3-GLN44 | |
| L | ASP3-GLN44 | |
| C | ASP3-GLN44 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 282 |
| Details | DNA_BIND: Integrase-type => ECO:0000255|PROSITE-ProRule:PRU00506 |
| Chain | Residue | Details |
| A | PHE223-ASP270 | |
| B | PHE223-ASP270 | |
| I | PHE223-ASP270 | |
| K | PHE223-ASP270 | |
| L | PHE223-ASP270 | |
| C | PHE223-ASP270 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 24 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00450 |
| Chain | Residue | Details |
| A | HIS12 | |
| I | HIS16 | |
| I | CYS40 | |
| I | CYS43 | |
| K | HIS12 | |
| K | HIS16 | |
| K | CYS40 | |
| K | CYS43 | |
| L | HIS12 | |
| L | HIS16 | |
| L | CYS40 | |
| A | HIS16 | |
| L | CYS43 | |
| C | HIS12 | |
| C | HIS16 | |
| C | CYS40 | |
| C | CYS43 | |
| A | CYS40 | |
| A | CYS43 | |
| B | HIS12 | |
| B | HIS16 | |
| B | CYS40 | |
| B | CYS43 | |
| I | HIS12 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | ASP64 | |
| L | ASP116 | |
| C | ASP64 | |
| C | ASP116 | |
| A | ASP116 | |
| B | ASP64 | |
| B | ASP116 | |
| I | ASP64 | |
| I | ASP116 | |
| K | ASP64 | |
| K | ASP116 | |
| L | ASP64 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P04585 |
| Chain | Residue | Details |
| A | GLU152 | |
| B | GLU152 | |
| I | GLU152 | |
| K | GLU152 | |
| L | GLU152 | |
| C | GLU152 |
