9C7E
Diheteromeric GluN1/GluN2A (delM653) in nanodisc complex with glycine, glutamate, and GNE-4123, open conformation, C2 symmetry
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Glutamate receptor ionotropic, NMDA 1,Green fluorescent protein chimera | polymer | 1108 | 124759.2 | 2 | UniProt (P35439) UniProt (P42212) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) Pfam (PF01353) | Rattus norvegicus (Norway rat) | GluN1,Glutamate [NMDA] receptor subunit zeta-1,N-methyl-D-aspartate receptor subunit NR1,NMD-R1 |
| 2 | B, D (B, D) | Glutamate receptor ionotropic, NMDA 2A,Green fluorescent protein chimera | polymer | 1126 | 126356.2 | 2 | UniProt (Q00959) UniProt (P42212) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) Pfam (PF01353) | Rattus norvegicus (Norway rat) | GluN2A,Glutamate [NMDA] receptor subunit epsilon-1,N-methyl D-aspartate receptor subtype 2A,NMDAR2A,NR2A |
| 3 | E, J (A, C) | 4-cyclohexyl-N-[(8R)-2-cyclopropyl-7-hydroxy-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]benzene-1-sulfonamide | non-polymer | 427.5 | 2 | Chemie (A1AUV) | |||
| 4 | F, G, I, K, L... (B, D) | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 6 | Chemie (Y01) | |||
| 5 | H, M (B, D) | DODECANE | non-polymer | 170.3 | 2 | Chemie (D12) |
Sequence modifications
A, C: 1 - 847 (UniProt: P35439)
A, C: 862 - 1095 (UniProt: P42212)
B, D: 1 - 865 (UniProt: Q00959)
B, D: 877 - 1113 (UniProt: P42212)
| PDB | External Database | Details |
|---|---|---|
| Leu 848 | - | linker |
| Val 849 | - | linker |
| Pro 850 | - | linker |
| Arg 851 | - | linker |
| Gly 852 | - | linker |
| Ser 853 | - | linker |
| Ala 854 | - | linker |
| Ala 855 | - | linker |
| Ala 856 | - | linker |
| Ala 857 | - | linker |
| Val 858 | - | linker |
| Ser 859 | - | linker |
| Lys 860 | - | linker |
| Gly 861 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Leu 921 | Phe 64 | conflict |
| Thr 922 | Ser 65 | conflict |
| Lys 1063 | Ala 206 | conflict |
| Leu 1088 | His 231 | conflict |
| Ser 1096 | - | expression tag |
| Gly 1097 | - | expression tag |
| Leu 1098 | - | expression tag |
| Arg 1099 | - | expression tag |
| Ser 1100 | - | expression tag |
| His 1101 | - | expression tag |
| His 1102 | - | expression tag |
| His 1103 | - | expression tag |
| His 1104 | - | expression tag |
| His 1105 | - | expression tag |
| His 1106 | - | expression tag |
| His 1107 | - | expression tag |
| His 1108 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| - | Met 653 | deletion |
| Thr 757 | Ser 758 | conflict |
| Leu 866 | - | linker |
| Val 867 | - | linker |
| Pro 868 | - | linker |
| Arg 869 | - | linker |
| Gly 870 | - | linker |
| Ser 871 | - | linker |
| Ala 872 | - | linker |
| Ala 873 | - | linker |
| Ala 874 | - | linker |
| Ala 875 | - | linker |
| Val 876 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Leu 939 | Phe 64 | conflict |
| Thr 940 | Ser 65 | conflict |
| Lys 1081 | Ala 206 | conflict |
| Leu 1106 | His 231 | conflict |
| Ser 1114 | - | expression tag |
| Gly 1115 | - | expression tag |
| Leu 1116 | - | expression tag |
| Arg 1117 | - | expression tag |
| Ser 1118 | - | expression tag |
| Trp 1119 | - | expression tag |
| Ser 1120 | - | expression tag |
| His 1121 | - | expression tag |
| Pro 1122 | - | expression tag |
| Gln 1123 | - | expression tag |
| Phe 1124 | - | expression tag |
| Glu 1125 | - | expression tag |
| Lys 1126 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 502230.8 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 4116.1 | |
| All* | Total formula weight | 506346.9 |
