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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9C7E

Diheteromeric GluN1/GluN2A (delM653) in nanodisc complex with glycine, glutamate, and GNE-4123, open conformation, C2 symmetry

This is a non-PDB format compatible entry.
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues112
DetailsTransmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"24876489","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues42
DetailsIntramembrane: {"description":"Discontinuously helical","evidences":[{"source":"UniProtKB","id":"A0A1L8F5J9","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues10
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"24876489","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues328
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"24876489","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues42
DetailsRegion: {"description":"Pore-forming","evidences":[{"source":"UniProtKB","id":"A0A1L8F5J9","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"16281028","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24876489","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27618671","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28468946","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"APR-2017","submissionDatabase":"PDB data bank","title":"Crystal structure of GluN1/GluN2A NMDA receptor agonist binding domains with glycine and antagonist, phenyl-ACEPC.","authors":["Mou T.C.","Sprang S.R.","Hansen K.B."]}},{"source":"PDB","id":"2A5T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PE5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DEX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I57","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I59","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5U8C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VIH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VII","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VIJ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"12805203","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16281028","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24876489","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27618671","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28468946","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"APR-2017","submissionDatabase":"PDB data bank","title":"Crystal structure of GluN1/GluN2A NMDA receptor agonist binding domains with glycine and antagonist, phenyl-ACEPC.","authors":["Mou T.C.","Sprang S.R.","Hansen K.B."]}},{"source":"PDB","id":"1PB7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2A5T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PE5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DEX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I57","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I59","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VIH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VII","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VIJ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"12805203","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16281028","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24876489","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27618671","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28468946","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"APR-2017","submissionDatabase":"PDB data bank","title":"Crystal structure of GluN1/GluN2A NMDA receptor agonist binding domains with glycine and antagonist, phenyl-ACEPC.","authors":["Mou T.C.","Sprang S.R.","Hansen K.B."]}},{"source":"PDB","id":"1PB7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2A5T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PE5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DEX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I57","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I59","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5U8C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VIH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VII","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VIJ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PDB","id":"3Q41","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"24876489","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3Q41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PE5","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24090084","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"24876489","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3Q41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PE5","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"24876489","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4PE5","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"24090084","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"24876489","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4PE5","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24090084","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues18
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues122
DetailsTransmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"30500536","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6MM9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MMA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MMB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MMG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MMH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MMI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MMJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MMK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MML","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MMM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MMN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MMP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MMR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MMS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MMT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MMU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MMV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MMW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MMX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues28
DetailsIntramembrane: {"description":"Discontinuously helical","evidences":[{"source":"UniProtKB","id":"Q12879","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues16
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"30500536","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues42
DetailsRegion: {"description":"Pore-forming","evidences":[{"source":"UniProtKB","id":"B7ZSK1","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"27916457","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5TPW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TQ2","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues10
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"16281028","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24462099","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27618671","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2A5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2A5T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NF4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NF8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I57","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I59","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JTY","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"16281028","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24462099","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27618671","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2A5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2A5T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NF4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NF8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I57","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JTY","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues2
DetailsSite: {"description":"Functional determinant of NMDA receptors","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

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