9C6V

Crystal Structure of a single chain trimer composed of HLA-B*39:06 Y84C variant, beta-2microglobulin, and NRVMLPKAA peptide from NLRP2 (1 molecule/asymmetric unit)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	NACHT, LRR and PYD domains-containing protein 2,Beta-2-microglobulin,MHC class I antigen	polymer	419	46912.5	1	UniProt (Q9NX02) UniProt (P61769) UniProt (I3ZN83) In PDB	Homo sapiens (human)	Nucleotide-binding site protein 1,PYRIN domain and NACHT domain-containing protein 1,PYRIN-containing APAF1-like protein 2,Major histocompatibility complex
2	A	1,2-ETHANEDIOL	non-polymer		62.1	1	Chemie (EDO)
3	A	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
4	A	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
5		water	water		18.0	158	Chemie (HOH)

Sequence modifications

A: 323 - 331 (UniProt: Q9NX02)

PDB	External Database	Details
Gly 332	-	linker
Cys 333	-	linker
Gly 988	-	linker
Ala 989	-	linker
Ser 990	-	linker
Gly 991	-	linker
Gly 992	-	linker
Gly 993	-	linker
Gly 994	-	linker
Ser 995	-	linker
Gly 996	-	linker
Gly 997	-	linker
Gly 998	-	linker
Gly 999	-	linker
Ser 1000	-	linker
Met 1001	-	linker

A: 1002 - 1980 (UniProt: P61769)

PDB	External Database	Details
Gly 1981	-	linker
Gly 1982	-	linker
Gly 1983	-	linker
Gly 1984	-	linker
Ser 1985	-	linker
Gly 1986	-	linker
Gly 1987	-	linker
Gly 1988	-	linker
Gly 1989	-	linker
Ser 1990	-	linker
Gly 1991	-	linker
Gly 1992	-	linker
Gly 1993	-	linker
Gly 1994	-	linker
Ser 1995	-	linker
Gly 1996	-	linker
Gly 1997	-	linker
Gly 1998	-	linker
Gly 1999	-	linker
Ser 2000	-	linker

A: 2001 - 2275 (UniProt: I3ZN83)

PDB	External Database	Details
Cys 2084	Tyr 108	variant

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	46912.5
Non-Polymers*	Number of molecules	3
	Total formula weight	189.6
All*	Total formula weight	47102.2

*Water molecules are not included.