9C59
Human AP-3 dimer bound to myristoylated Arf1 (Q71L) and LAMP1 cargo on a lipid nanodisc
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, H (D, d) | AP-3 complex subunit delta-1 | polymer | 617 | 69382.0 | 2 | UniProt (O14617) Pfam (PF01602) | Homo sapiens (human) | AP-3 complex subunit delta,Adaptor-related protein complex 3 subunit delta-1,Delta-adaptin |
| 2 | B, I (B, b) | AP-3 complex subunit beta-1 | polymer | 677 | 76499.6 | 2 | UniProt (O00203) Pfam (PF01602) | Homo sapiens (human) | Adaptor protein complex AP-3 subunit beta-1,Adaptor-related protein complex 3 subunit beta-1,Beta-3A-adaptin,Clathrin assembly protein complex 3 beta-1 large chain |
| 3 | C, J (M, m) | AP-3 complex subunit mu-1 | polymer | 418 | 46990.0 | 2 | UniProt (Q9Y2T2) Pfam (PF01217) Pfam (PF00928) | Homo sapiens (human) | AP-3 adaptor complex mu3A subunit,Adaptor-related protein complex 3 subunit mu-1,Mu-adaptin 3A,Mu3A-adaptin |
| 4 | D, K (S, s) | AP-3 complex subunit sigma-1 | polymer | 193 | 21755.1 | 2 | UniProt (Q92572) Pfam (PF01217) | Homo sapiens (human) | AP-3 complex subunit sigma-3A,Adaptor-related protein complex 3 subunit sigma-1,Clathrin-associated/assembly/adaptor protein,small 3,Sigma-3A-adaptin,Sigma3A-adaptin,Sigma-adaptin 3a |
| 5 | E, F, L, M (A, C, a, c) | ADP-ribosylation factor 1 | polymer | 182 | 20775.8 | 4 | UniProt (P84077) Pfam (PF00025) | Homo sapiens (human) | |
| 6 | G, N (Y, y) | Lysosome-associated membrane glycoprotein 1 | polymer | 12 | 1377.6 | 2 | UniProt (P11279) | Homo sapiens (human) | LAMP-1,Lysosome-associated membrane protein 1,CD107 antigen-like family member A |
| 7 | O, Q, S, U (A, C, a, c) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) PubChem (888) | |||
| 8 | P, R, T, V (A, C, a, c) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 4 | Chemie (GTP) PubChem (177679032) PubChem (135400627) PubChem (135487750) PubChem (136088935) PubChem (136803486) PubChem (135398633) PubChem (135544356) PubChem (135547949) PubChem (135600366) PubChem (135749822) PubChem (136005188) PubChem (136073923) PubChem (136240914) PubChem (136664747) PubChem (136772743) PubChem (136772744) PubChem (136803487) PubChem (137286749) PubChem (164715984) PubChem (171699466) |
Sequence modifications
A, C, a, c: 2 - 181 (UniProt: P84077)
| PDB | External Database | Details |
|---|---|---|
| Leu 71 | Gln 71 | engineered mutation |
| Ser 182 | - | expression tag |
| Leu 183 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 14 |
| Total formula weight | 515111.6 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 2189.9 | |
| All* | Total formula weight | 517301.5 |
