Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

9C59

Human AP-3 dimer bound to myristoylated Arf1 (Q71L) and LAMP1 cargo on a lipid nanodisc

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000139	cellular_component	Golgi membrane
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0002090	biological_process	regulation of receptor internalization
A	0003723	molecular_function	RNA binding
A	0003924	molecular_function	GTPase activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0005794	cellular_component	Golgi apparatus
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0005925	cellular_component	focal adhesion
A	0006878	biological_process	intracellular copper ion homeostasis
A	0006886	biological_process	intracellular protein transport
A	0012505	cellular_component	endomembrane system
A	0014069	cellular_component	postsynaptic density
A	0015031	biological_process	protein transport
A	0016020	cellular_component	membrane
A	0016192	biological_process	vesicle-mediated transport
A	0016787	molecular_function	hydrolase activity
A	0019904	molecular_function	protein domain specific binding
A	0030017	cellular_component	sarcomere
A	0031252	cellular_component	cell leading edge
A	0032991	cellular_component	protein-containing complex
A	0034315	biological_process	regulation of Arp2/3 complex-mediated actin nucleation
A	0043005	cellular_component	neuron projection
A	0045202	cellular_component	synapse
A	0060292	biological_process	long-term synaptic depression
A	0070062	cellular_component	extracellular exosome
A	0097061	biological_process	dendritic spine organization
A	0098586	biological_process	cellular response to virus
A	1990386	biological_process	mitotic cleavage furrow ingression
B	0006886	biological_process	intracellular protein transport
B	0015031	biological_process	protein transport
B	0016192	biological_process	vesicle-mediated transport
B	0030117	cellular_component	membrane coat
B	0030276	molecular_function	clathrin binding
C	0000139	cellular_component	Golgi membrane
C	0000166	molecular_function	nucleotide binding
C	0000287	molecular_function	magnesium ion binding
C	0002090	biological_process	regulation of receptor internalization
C	0003723	molecular_function	RNA binding
C	0003924	molecular_function	GTPase activity
C	0005515	molecular_function	protein binding
C	0005525	molecular_function	GTP binding
C	0005737	cellular_component	cytoplasm
C	0005794	cellular_component	Golgi apparatus
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0005925	cellular_component	focal adhesion
C	0006878	biological_process	intracellular copper ion homeostasis
C	0006886	biological_process	intracellular protein transport
C	0012505	cellular_component	endomembrane system
C	0014069	cellular_component	postsynaptic density
C	0015031	biological_process	protein transport
C	0016020	cellular_component	membrane
C	0016192	biological_process	vesicle-mediated transport
C	0016787	molecular_function	hydrolase activity
C	0019904	molecular_function	protein domain specific binding
C	0030017	cellular_component	sarcomere
C	0031252	cellular_component	cell leading edge
C	0032991	cellular_component	protein-containing complex
C	0034315	biological_process	regulation of Arp2/3 complex-mediated actin nucleation
C	0043005	cellular_component	neuron projection
C	0045202	cellular_component	synapse
C	0060292	biological_process	long-term synaptic depression
C	0070062	cellular_component	extracellular exosome
C	0097061	biological_process	dendritic spine organization
C	0098586	biological_process	cellular response to virus
C	1990386	biological_process	mitotic cleavage furrow ingression
D	0006886	biological_process	intracellular protein transport
D	0015031	biological_process	protein transport
D	0016192	biological_process	vesicle-mediated transport
D	0030117	cellular_component	membrane coat
D	0030123	cellular_component	AP-3 adaptor complex
M	0005515	molecular_function	protein binding
M	0005737	cellular_component	cytoplasm
M	0005764	cellular_component	lysosome
M	0005765	cellular_component	lysosomal membrane
M	0005769	cellular_component	early endosome
M	0005794	cellular_component	Golgi apparatus
M	0006622	biological_process	protein targeting to lysosome
M	0006886	biological_process	intracellular protein transport
M	0006897	biological_process	endocytosis
M	0008089	biological_process	anterograde axonal transport
M	0015031	biological_process	protein transport
M	0016020	cellular_component	membrane
M	0016192	biological_process	vesicle-mediated transport
M	0030123	cellular_component	AP-3 adaptor complex
M	0030131	cellular_component	clathrin adaptor complex
M	0030659	cellular_component	cytoplasmic vesicle membrane
M	0031267	molecular_function	small GTPase binding
M	0031410	cellular_component	cytoplasmic vesicle
M	0035654	biological_process	clathrin-coated vesicle cargo loading, AP-3-mediated
M	0048490	biological_process	anterograde synaptic vesicle transport
M	0060155	biological_process	platelet dense granule organization
M	0098837	cellular_component	postsynaptic recycling endosome
M	0098884	biological_process	postsynaptic neurotransmitter receptor internalization
M	1903232	biological_process	melanosome assembly
M	1904115	cellular_component	axon cytoplasm
S	0005515	molecular_function	protein binding
S	0005769	cellular_component	early endosome
S	0005794	cellular_component	Golgi apparatus
S	0006886	biological_process	intracellular protein transport
S	0006896	biological_process	Golgi to vacuole transport
S	0008089	biological_process	anterograde axonal transport
S	0008286	biological_process	insulin receptor signaling pathway
S	0015031	biological_process	protein transport
S	0016020	cellular_component	membrane
S	0016183	biological_process	synaptic vesicle coating
S	0016192	biological_process	vesicle-mediated transport
S	0030117	cellular_component	membrane coat
S	0030119	cellular_component	AP-type membrane coat adaptor complex
S	0030123	cellular_component	AP-3 adaptor complex
S	0030133	cellular_component	transport vesicle
S	0030659	cellular_component	cytoplasmic vesicle membrane
S	0031410	cellular_component	cytoplasmic vesicle
S	0035654	biological_process	clathrin-coated vesicle cargo loading, AP-3-mediated
S	0036465	biological_process	synaptic vesicle recycling
S	0048490	biological_process	anterograde synaptic vesicle transport
S	0060155	biological_process	platelet dense granule organization
S	0098793	cellular_component	presynapse
S	1903232	biological_process	melanosome assembly
S	1904115	cellular_component	axon cytoplasm
a	0000139	cellular_component	Golgi membrane
a	0000166	molecular_function	nucleotide binding
a	0000287	molecular_function	magnesium ion binding
a	0002090	biological_process	regulation of receptor internalization
a	0003723	molecular_function	RNA binding
a	0003924	molecular_function	GTPase activity
a	0005515	molecular_function	protein binding
a	0005525	molecular_function	GTP binding
a	0005737	cellular_component	cytoplasm
a	0005794	cellular_component	Golgi apparatus
a	0005829	cellular_component	cytosol
a	0005886	cellular_component	plasma membrane
a	0005925	cellular_component	focal adhesion
a	0006878	biological_process	intracellular copper ion homeostasis
a	0006886	biological_process	intracellular protein transport
a	0012505	cellular_component	endomembrane system
a	0014069	cellular_component	postsynaptic density
a	0015031	biological_process	protein transport
a	0016020	cellular_component	membrane
a	0016192	biological_process	vesicle-mediated transport
a	0016787	molecular_function	hydrolase activity
a	0019904	molecular_function	protein domain specific binding
a	0030017	cellular_component	sarcomere
a	0031252	cellular_component	cell leading edge
a	0032991	cellular_component	protein-containing complex
a	0034315	biological_process	regulation of Arp2/3 complex-mediated actin nucleation
a	0043005	cellular_component	neuron projection
a	0045202	cellular_component	synapse
a	0060292	biological_process	long-term synaptic depression
a	0070062	cellular_component	extracellular exosome
a	0097061	biological_process	dendritic spine organization
a	0098586	biological_process	cellular response to virus
a	1990386	biological_process	mitotic cleavage furrow ingression
b	0006886	biological_process	intracellular protein transport
b	0015031	biological_process	protein transport
b	0016192	biological_process	vesicle-mediated transport
b	0030117	cellular_component	membrane coat
b	0030276	molecular_function	clathrin binding
c	0000139	cellular_component	Golgi membrane
c	0000166	molecular_function	nucleotide binding
c	0000287	molecular_function	magnesium ion binding
c	0002090	biological_process	regulation of receptor internalization
c	0003723	molecular_function	RNA binding
c	0003924	molecular_function	GTPase activity
c	0005515	molecular_function	protein binding
c	0005525	molecular_function	GTP binding
c	0005737	cellular_component	cytoplasm
c	0005794	cellular_component	Golgi apparatus
c	0005829	cellular_component	cytosol
c	0005886	cellular_component	plasma membrane
c	0005925	cellular_component	focal adhesion
c	0006878	biological_process	intracellular copper ion homeostasis
c	0006886	biological_process	intracellular protein transport
c	0012505	cellular_component	endomembrane system
c	0014069	cellular_component	postsynaptic density
c	0015031	biological_process	protein transport
c	0016020	cellular_component	membrane
c	0016192	biological_process	vesicle-mediated transport
c	0016787	molecular_function	hydrolase activity
c	0019904	molecular_function	protein domain specific binding
c	0030017	cellular_component	sarcomere
c	0031252	cellular_component	cell leading edge
c	0032991	cellular_component	protein-containing complex
c	0034315	biological_process	regulation of Arp2/3 complex-mediated actin nucleation
c	0043005	cellular_component	neuron projection
c	0045202	cellular_component	synapse
c	0060292	biological_process	long-term synaptic depression
c	0070062	cellular_component	extracellular exosome
c	0097061	biological_process	dendritic spine organization
c	0098586	biological_process	cellular response to virus
c	1990386	biological_process	mitotic cleavage furrow ingression
d	0006886	biological_process	intracellular protein transport
d	0015031	biological_process	protein transport
d	0016192	biological_process	vesicle-mediated transport
d	0030117	cellular_component	membrane coat
d	0030123	cellular_component	AP-3 adaptor complex
m	0005515	molecular_function	protein binding
m	0005737	cellular_component	cytoplasm
m	0005764	cellular_component	lysosome
m	0005765	cellular_component	lysosomal membrane
m	0005769	cellular_component	early endosome
m	0005794	cellular_component	Golgi apparatus
m	0006622	biological_process	protein targeting to lysosome
m	0006886	biological_process	intracellular protein transport
m	0006897	biological_process	endocytosis
m	0008089	biological_process	anterograde axonal transport
m	0015031	biological_process	protein transport
m	0016020	cellular_component	membrane
m	0016192	biological_process	vesicle-mediated transport
m	0030123	cellular_component	AP-3 adaptor complex
m	0030131	cellular_component	clathrin adaptor complex
m	0030659	cellular_component	cytoplasmic vesicle membrane
m	0031267	molecular_function	small GTPase binding
m	0031410	cellular_component	cytoplasmic vesicle
m	0035654	biological_process	clathrin-coated vesicle cargo loading, AP-3-mediated
m	0048490	biological_process	anterograde synaptic vesicle transport
m	0060155	biological_process	platelet dense granule organization
m	0098837	cellular_component	postsynaptic recycling endosome
m	0098884	biological_process	postsynaptic neurotransmitter receptor internalization
m	1903232	biological_process	melanosome assembly
m	1904115	cellular_component	axon cytoplasm
s	0005515	molecular_function	protein binding
s	0005769	cellular_component	early endosome
s	0005794	cellular_component	Golgi apparatus
s	0006886	biological_process	intracellular protein transport
s	0006896	biological_process	Golgi to vacuole transport
s	0008089	biological_process	anterograde axonal transport
s	0008286	biological_process	insulin receptor signaling pathway
s	0015031	biological_process	protein transport
s	0016020	cellular_component	membrane
s	0016183	biological_process	synaptic vesicle coating
s	0016192	biological_process	vesicle-mediated transport
s	0030117	cellular_component	membrane coat
s	0030119	cellular_component	AP-type membrane coat adaptor complex
s	0030123	cellular_component	AP-3 adaptor complex
s	0030133	cellular_component	transport vesicle
s	0030659	cellular_component	cytoplasmic vesicle membrane
s	0031410	cellular_component	cytoplasmic vesicle
s	0035654	biological_process	clathrin-coated vesicle cargo loading, AP-3-mediated
s	0036465	biological_process	synaptic vesicle recycling
s	0048490	biological_process	anterograde synaptic vesicle transport
s	0060155	biological_process	platelet dense granule organization
s	0098793	cellular_component	presynapse
s	1903232	biological_process	melanosome assembly
s	1904115	cellular_component	axon cytoplasm

Functional Information from PROSITE/UniProt

site_id	PS00989
Number of Residues	11
Details	CLAT_ADAPTOR_S Clathrin adaptor complexes small chain signature. LIYRhyatLYF

Chain	Residue	Details
S	LEU63-PHE73

site_id	PS00990
Number of Residues	21
Details	CLAT_ADAPTOR_M_1 Clathrin adaptor complexes medium chain signature 1. IPWRra.GvkYtnNeAYFDVVE

Chain	Residue	Details
M	ILE165-GLU185

site_id	PS00991
Number of Residues	15
Details	CLAT_ADAPTOR_M_2 Clathrin adaptor complexes medium chain signature 2. LsFIPPdGnFrLisY

Chain	Residue	Details
M	LEU248-TYR262

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	TOPO_DOM: Cytoplasmic => ECO:0000255\|PROSITE-ProRule:PRU00740

Chain	Residue	Details
Y	HIS411-ILE417
y	HIS411-ILE417
a	GLY24
c	GLY24

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:14690595, ECO:0000269\|PubMed:15308674, ECO:0000269\|PubMed:7990966, ECO:0000269\|Ref.34, ECO:0007744\|PDB:1HUR, ECO:0007744\|PDB:1RE0, ECO:0007744\|PDB:1U81, ECO:0007744\|PDB:3O47

Chain	Residue	Details
A	ASN126
C	ASN126
a	ASN126
c	ASN126

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:15308674, ECO:0000269\|PubMed:7990966, ECO:0000269\|Ref.34, ECO:0007744\|PDB:1HUR, ECO:0007744\|PDB:1RE0, ECO:0007744\|PDB:3O47

Chain	Residue	Details
A	ALA160
C	ALA160
a	ALA160
c	ALA160

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: N-acetylglycine; alternate => ECO:0007744\|PubMed:19413330, ECO:0007744\|PubMed:22223895

Chain	Residue	Details
A	GLY2
C	GLY2
a	GLY2
c	GLY2

site_id	SWS_FT_FI5
Number of Residues	4
Details	LIPID: N-myristoyl glycine; alternate => ECO:0000269\|PubMed:20213681, ECO:0000269\|PubMed:23535599, ECO:0000269\|PubMed:25255805, ECO:0000269\|PubMed:25807930

Chain	Residue	Details
A	GLY2
C	GLY2
a	GLY2
c	GLY2

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)