9C4Y

Menin mutant - T349M

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Menin	polymer	489	54600.3	1	UniProt (O00255) Pfam (PF05053)	Homo sapiens (human)
2	B, D (A)	1,2-ETHANEDIOL	non-polymer		62.1	2	Chemie (EDO)
3	C (A)	TETRAETHYLENE GLYCOL	non-polymer		194.2	1	Chemie (PG4)
4	E, G (A)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	2	Chemie (PEG)
5	F (A)	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
6	H (A)	water	water		18.0	588	Chemie (HOH)

Sequence modifications

A: 1 - 459 (UniProt: O00255)

PDB	External Database	Details
Gly -4	-	expression tag
Gly -3	-	expression tag
Ser -2	-	expression tag
Ser -1	-	expression tag
Ser 0	-	expression tag
-	Ile 54	deletion
-	Pro 55	deletion
-	Thr 56	deletion
-	Asn 57	deletion
-	Val 58	deletion
-	Pro 59	deletion
-	Glu 60	deletion
-	Leu 61	deletion
-	Thr 62	deletion
-	Phe 63	deletion
-	Gln 64	deletion
-	Pro 65	deletion
-	Ser 66	deletion
-	Pro 67	deletion
-	Ala 68	deletion
-	Pro 69	deletion
-	Asp 70	deletion
-	Pro 71	deletion
-	Pro 72	deletion
-	Gly 73	deletion
Met 344	Thr 344	engineered mutation
-	Glu 387	deletion
-	Glu 388	deletion
-	Arg 389	deletion
-	Pro 390	deletion
-	Gly 391	deletion
-	Glu 392	deletion
-	Gln 393	deletion
-	Ser 394	deletion
-	Gln 395	deletion
-	Gly 396	deletion
-	Thr 397	deletion
-	Gln 398	deletion

A: 460 - 593 (UniProt: O00255)

PDB	External Database	Details
Ala 541	Thr 541	variant

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	54600.3
Non-Polymers*	Number of molecules	6
	Total formula weight	626.7
All*	Total formula weight	55227.0

*Water molecules are not included.