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9C48

Cryo-EM structure of the full-length human P2X4 receptor in the ATP-bound desensitized state

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, C
(A, B, C)
P2X purinoceptor 4polymer38843415.03UniProt (Q99571)
Pfam (PF00864)
Homo sapiens (human)P2X4,ATP receptor,Purinergic receptor
2D, E, G, H, J...
(D, E, G, H, J...)
2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosebranched424.46In PDB
GlyTouCan (G42666HT)
3F, I, L
(F, I, L)
beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosebranched586.53In PDB
GlyTouCan (G15407YE)
4M, S, X
(A, B, C)
ADENOSINE-5'-TRIPHOSPHATEnon-polymer507.23Chemie (ATP)
5AA, N, O, P, T...
(C, A, B)
2-acetamido-2-deoxy-beta-D-glucopyranosenon-polymer221.29Chemie (NAG)
6Q, R, W
(A, B, C)
MAGNESIUM IONnon-polymer24.33Chemie (MG)
PubChem (888)
7BA, CA, DA
(A, B, C)
waterwater18.0249Chemie (HOH)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains3
Total formula weight130245.0
BranchedNumber of molecules9
Total formula weight4306.0
Non-Polymers*Number of molecules15
Total formula weight3585.3
All*Total formula weight138136.4
*Water molecules are not included.

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PDB entries from 2026-03-25

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