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9C48

Cryo-EM structure of the full-length human P2X4 receptor in the ATP-bound desensitized state

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, C
(A, B, C)
P2X purinoceptor 4polymer38843415.03UniProt (Q99571)
Pfam (PF00864)
Homo sapiens (human)P2X4,ATP receptor,Purinergic receptor
2D, E, G, H, J...
(D, E, G, H, J...)
2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosebranched424.46In PDB
GlyTouCan (G42666HT)
3F, I, L
(F, I, L)
beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosebranched586.53In PDB
GlyTouCan (G15407YE)
4M, S, X
(A, B, C)
ADENOSINE-5'-TRIPHOSPHATEnon-polymer507.23Chemie (ATP)
5AA, N, O, P, T...
(C, A, B)
2-acetamido-2-deoxy-beta-D-glucopyranosenon-polymer221.29Chemie (NAG)
6Q, R, W
(A, B, C)
MAGNESIUM IONnon-polymer24.33Chemie (MG)
7BA, CA, DA
(A, B, C)
waterwater18.0249Chemie (HOH)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains3
Total formula weight130245.0
BranchedNumber of molecules9
Total formula weight4306.0
Non-Polymers*Number of molecules15
Total formula weight3585.3
All*Total formula weight138136.4
*Water molecules are not included.

238268

PDB entries from 2025-07-02

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