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9C48

Cryo-EM structure of the full-length human P2X4 receptor in the ATP-bound desensitized state

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0001614molecular_functionpurinergic nucleotide receptor activity
A0001894biological_processtissue homeostasis
A0002028biological_processregulation of sodium ion transport
A0002931biological_processresponse to ischemia
A0004931molecular_functionextracellularly ATP-gated monoatomic cation channel activity
A0005102molecular_functionsignaling receptor binding
A0005216molecular_functionmonoatomic ion channel activity
A0005507molecular_functioncopper ion binding
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005764cellular_componentlysosome
A0005765cellular_componentlysosomal membrane
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006950biological_processresponse to stress
A0007165biological_processsignal transduction
A0008217biological_processregulation of blood pressure
A0008270molecular_functionzinc ion binding
A0010524biological_processpositive regulation of calcium ion transport into cytosol
A0010614biological_processnegative regulation of cardiac muscle hypertrophy
A0010959biological_processregulation of metal ion transport
A0016020cellular_componentmembrane
A0019233biological_processsensory perception of pain
A0019722biological_processcalcium-mediated signaling
A0030054cellular_componentcell junction
A0030335biological_processpositive regulation of cell migration
A0032308biological_processpositive regulation of prostaglandin secretion
A0033198biological_processresponse to ATP
A0034220biological_processmonoatomic ion transmembrane transport
A0034405biological_processresponse to fluid shear stress
A0035590biological_processpurinergic nucleotide receptor signaling pathway
A0042118biological_processendothelial cell activation
A0042802molecular_functionidentical protein binding
A0043536biological_processpositive regulation of blood vessel endothelial cell migration
A0044297cellular_componentcell body
A0045296molecular_functioncadherin binding
A0045429biological_processpositive regulation of nitric oxide biosynthetic process
A0048266biological_processbehavioral response to pain
A0048471cellular_componentperinuclear region of cytoplasm
A0048678biological_processresponse to axon injury
A0050850biological_processpositive regulation of calcium-mediated signaling
A0050920biological_processregulation of chemotaxis
A0050975biological_processsensory perception of touch
A0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0051899biological_processmembrane depolarization
A0051928biological_processpositive regulation of calcium ion transport
A0055117biological_processregulation of cardiac muscle contraction
A0055119biological_processrelaxation of cardiac muscle
A0060079biological_processexcitatory postsynaptic potential
A0070062cellular_componentextracellular exosome
A0070588biological_processcalcium ion transmembrane transport
A0071294biological_processcellular response to zinc ion
A0071318biological_processcellular response to ATP
A0097190biological_processapoptotic signaling pathway
A0098655biological_processmonoatomic cation transmembrane transport
A0098794cellular_componentpostsynapse
A0099604molecular_functionligand-gated calcium channel activity
A1900027biological_processregulation of ruffle assembly
A1902533biological_processpositive regulation of intracellular signal transduction
A1904141biological_processpositive regulation of microglial cell migration
A2001028biological_processpositive regulation of endothelial cell chemotaxis
B0000166molecular_functionnucleotide binding
B0001614molecular_functionpurinergic nucleotide receptor activity
B0001894biological_processtissue homeostasis
B0002028biological_processregulation of sodium ion transport
B0002931biological_processresponse to ischemia
B0004931molecular_functionextracellularly ATP-gated monoatomic cation channel activity
B0005102molecular_functionsignaling receptor binding
B0005216molecular_functionmonoatomic ion channel activity
B0005507molecular_functioncopper ion binding
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005764cellular_componentlysosome
B0005765cellular_componentlysosomal membrane
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006950biological_processresponse to stress
B0007165biological_processsignal transduction
B0008217biological_processregulation of blood pressure
B0008270molecular_functionzinc ion binding
B0010524biological_processpositive regulation of calcium ion transport into cytosol
B0010614biological_processnegative regulation of cardiac muscle hypertrophy
B0010959biological_processregulation of metal ion transport
B0016020cellular_componentmembrane
B0019233biological_processsensory perception of pain
B0019722biological_processcalcium-mediated signaling
B0030054cellular_componentcell junction
B0030335biological_processpositive regulation of cell migration
B0032308biological_processpositive regulation of prostaglandin secretion
B0033198biological_processresponse to ATP
B0034220biological_processmonoatomic ion transmembrane transport
B0034405biological_processresponse to fluid shear stress
B0035590biological_processpurinergic nucleotide receptor signaling pathway
B0042118biological_processendothelial cell activation
B0042802molecular_functionidentical protein binding
B0043536biological_processpositive regulation of blood vessel endothelial cell migration
B0044297cellular_componentcell body
B0045296molecular_functioncadherin binding
B0045429biological_processpositive regulation of nitric oxide biosynthetic process
B0048266biological_processbehavioral response to pain
B0048471cellular_componentperinuclear region of cytoplasm
B0048678biological_processresponse to axon injury
B0050850biological_processpositive regulation of calcium-mediated signaling
B0050920biological_processregulation of chemotaxis
B0050975biological_processsensory perception of touch
B0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
B0051899biological_processmembrane depolarization
B0051928biological_processpositive regulation of calcium ion transport
B0055117biological_processregulation of cardiac muscle contraction
B0055119biological_processrelaxation of cardiac muscle
B0060079biological_processexcitatory postsynaptic potential
B0070062cellular_componentextracellular exosome
B0070588biological_processcalcium ion transmembrane transport
B0071294biological_processcellular response to zinc ion
B0071318biological_processcellular response to ATP
B0097190biological_processapoptotic signaling pathway
B0098655biological_processmonoatomic cation transmembrane transport
B0098794cellular_componentpostsynapse
B0099604molecular_functionligand-gated calcium channel activity
B1900027biological_processregulation of ruffle assembly
B1902533biological_processpositive regulation of intracellular signal transduction
B1904141biological_processpositive regulation of microglial cell migration
B2001028biological_processpositive regulation of endothelial cell chemotaxis
C0000166molecular_functionnucleotide binding
C0001614molecular_functionpurinergic nucleotide receptor activity
C0001894biological_processtissue homeostasis
C0002028biological_processregulation of sodium ion transport
C0002931biological_processresponse to ischemia
C0004931molecular_functionextracellularly ATP-gated monoatomic cation channel activity
C0005102molecular_functionsignaling receptor binding
C0005216molecular_functionmonoatomic ion channel activity
C0005507molecular_functioncopper ion binding
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005764cellular_componentlysosome
C0005765cellular_componentlysosomal membrane
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0006950biological_processresponse to stress
C0007165biological_processsignal transduction
C0008217biological_processregulation of blood pressure
C0008270molecular_functionzinc ion binding
C0010524biological_processpositive regulation of calcium ion transport into cytosol
C0010614biological_processnegative regulation of cardiac muscle hypertrophy
C0010959biological_processregulation of metal ion transport
C0016020cellular_componentmembrane
C0019233biological_processsensory perception of pain
C0019722biological_processcalcium-mediated signaling
C0030054cellular_componentcell junction
C0030335biological_processpositive regulation of cell migration
C0032308biological_processpositive regulation of prostaglandin secretion
C0033198biological_processresponse to ATP
C0034220biological_processmonoatomic ion transmembrane transport
C0034405biological_processresponse to fluid shear stress
C0035590biological_processpurinergic nucleotide receptor signaling pathway
C0042118biological_processendothelial cell activation
C0042802molecular_functionidentical protein binding
C0043536biological_processpositive regulation of blood vessel endothelial cell migration
C0044297cellular_componentcell body
C0045296molecular_functioncadherin binding
C0045429biological_processpositive regulation of nitric oxide biosynthetic process
C0048266biological_processbehavioral response to pain
C0048471cellular_componentperinuclear region of cytoplasm
C0048678biological_processresponse to axon injury
C0050850biological_processpositive regulation of calcium-mediated signaling
C0050920biological_processregulation of chemotaxis
C0050975biological_processsensory perception of touch
C0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
C0051899biological_processmembrane depolarization
C0051928biological_processpositive regulation of calcium ion transport
C0055117biological_processregulation of cardiac muscle contraction
C0055119biological_processrelaxation of cardiac muscle
C0060079biological_processexcitatory postsynaptic potential
C0070062cellular_componentextracellular exosome
C0070588biological_processcalcium ion transmembrane transport
C0071294biological_processcellular response to zinc ion
C0071318biological_processcellular response to ATP
C0097190biological_processapoptotic signaling pathway
C0098655biological_processmonoatomic cation transmembrane transport
C0098794cellular_componentpostsynapse
C0099604molecular_functionligand-gated calcium channel activity
C1900027biological_processregulation of ruffle assembly
C1902533biological_processpositive regulation of intracellular signal transduction
C1904141biological_processpositive regulation of microglial cell migration
C2001028biological_processpositive regulation of endothelial cell chemotaxis
Functional Information from PROSITE/UniProt
site_idPS01212
Number of Residues27
DetailsP2X_RECEPTOR ATP P2X receptors signature. GGiMGIqVnWdCNLDraaslClPrYsF
ChainResidueDetails
AGLY250-PHE276

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues180
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
AMET1-ARG33
ACYS360-GLN388
BMET1-ARG33
BCYS360-GLN388
CMET1-ARG33
CCYS360-GLN388

site_idSWS_FT_FI2
Number of Residues60
DetailsTRANSMEM: Helical; Name=1 => ECO:0000255
ChainResidueDetails
AALA34-TYR54
BALA34-TYR54
CALA34-TYR54

site_idSWS_FT_FI3
Number of Residues849
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
AGLN55-ASN338
BGLN55-ASN338
CGLN55-ASN338

site_idSWS_FT_FI4
Number of Residues60
DetailsTRANSMEM: Helical; Name=2 => ECO:0000255
ChainResidueDetails
AILE339-TYR359
BILE339-TYR359
CILE339-TYR359

site_idSWS_FT_FI5
Number of Residues21
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:F8W463
ChainResidueDetails
ALYS67
BTHR186
BLEU188
BASN293
BARG295
BLYS313
CLYS67
CLYS69
CTHR186
CLEU188
CASN293
ALYS69
CARG295
CLYS313
ATHR186
ALEU188
AASN293
AARG295
ALYS313
BLYS67
BLYS69

site_idSWS_FT_FI6
Number of Residues15
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN75
BASN208
CASN75
CASN110
CASN153
CASN199
CASN208
AASN110
AASN153
AASN199
AASN208
BASN75
BASN110
BASN153
BASN199

site_idSWS_FT_FI7
Number of Residues3
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218
ChainResidueDetails
AASN184
BASN184
CASN184

236620

PDB entries from 2025-05-28

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