9C48
Cryo-EM structure of the full-length human P2X4 receptor in the ATP-bound desensitized state
Functional Information from PROSITE/UniProt
| site_id | PS01212 |
| Number of Residues | 27 |
| Details | P2X_RECEPTOR ATP P2X receptors signature. GGiMGIqVnWdCNLDraaslClPrYsF |
| Chain | Residue | Details |
| A | GLY250-PHE276 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 180 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | MET1-ARG33 | |
| A | CYS360-GLN388 | |
| B | MET1-ARG33 | |
| B | CYS360-GLN388 | |
| C | MET1-ARG33 | |
| C | CYS360-GLN388 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 60 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000255 |
| Chain | Residue | Details |
| A | ALA34-TYR54 | |
| B | ALA34-TYR54 | |
| C | ALA34-TYR54 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 849 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| A | GLN55-ASN338 | |
| B | GLN55-ASN338 | |
| C | GLN55-ASN338 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 60 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000255 |
| Chain | Residue | Details |
| A | ILE339-TYR359 | |
| B | ILE339-TYR359 | |
| C | ILE339-TYR359 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 21 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:F8W463 |
| Chain | Residue | Details |
| A | LYS67 | |
| B | THR186 | |
| B | LEU188 | |
| B | ASN293 | |
| B | ARG295 | |
| B | LYS313 | |
| C | LYS67 | |
| C | LYS69 | |
| C | THR186 | |
| C | LEU188 | |
| C | ASN293 | |
| A | LYS69 | |
| C | ARG295 | |
| C | LYS313 | |
| A | THR186 | |
| A | LEU188 | |
| A | ASN293 | |
| A | ARG295 | |
| A | LYS313 | |
| B | LYS67 | |
| B | LYS69 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 15 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN75 | |
| B | ASN208 | |
| C | ASN75 | |
| C | ASN110 | |
| C | ASN153 | |
| C | ASN199 | |
| C | ASN208 | |
| A | ASN110 | |
| A | ASN153 | |
| A | ASN199 | |
| A | ASN208 | |
| B | ASN75 | |
| B | ASN110 | |
| B | ASN153 | |
| B | ASN199 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218 |
| Chain | Residue | Details |
| A | ASN184 | |
| B | ASN184 | |
| C | ASN184 |
