9C3E
TCR - CD3 complex bound to HLA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | TCRa | polymer | 272 | 30214.0 | 1 | Pfam (PF09291) UniProt (by SIFTS) (P01848) | Homo sapiens (human) | |
| 2 | B (B) | TCRb (EGFP fusion) | polymer | 557 | 62121.9 | 1 | Pfam (PF07686) Pfam (PF07654) UniProt (by SIFTS) (P0DTU4) | Homo sapiens (human) | |
| 3 | C (D) | T-cell surface glycoprotein CD3 delta chain | polymer | 125 | 13836.0 | 1 | UniProt (P04234) Pfam (PF16680) | Homo sapiens (human) | T-cell receptor T3 delta chain |
| 4 | D, E (E, F) | T-cell surface glycoprotein CD3 epsilon chain | polymer | 207 | 23174.2 | 2 | UniProt (P07766) Pfam (PF16681) Pfam (PF02189) | Homo sapiens (human) | |
| 5 | F (G) | T-cell surface glycoprotein CD3 gamma chain | polymer | 194 | 22041.1 | 1 | UniProt (P09693) Pfam (PF16680) Pfam (PF02189) | Homo sapiens (human) | T-cell receptor T3 gamma chain |
| 6 | G, H (X, Y) | T-cell surface glycoprotein CD3 zeta chain | polymer | 164 | 18723.4 | 2 | UniProt (P20963) Pfam (PF11628) Pfam (PF02189) | Homo sapiens (human) | T-cell receptor T3 zeta chain |
| 7 | I (H) | Cancer/testis antigen 1,Beta-2-microglobulin,MHC class I antigen | polymer | 593 | 62221.3 | 1 | UniProt (P78358) UniProt (P61769) UniProt (H9BNV4) Pfam (PF00129) Pfam (PF07654) | Homo sapiens (human) | Autoimmunogenic cancer/testis antigen NY-ESO-1,Cancer/testis antigen 6.1,CT6.1,L antigen family member 2,LAGE-2 |
| 8 | J (N) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 9 | K, L, M, N, O... (A, B, D, G) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 8 | Chemie (NAG) | |||
| 10 | S, T (G, Y) | CHOLESTEROL | non-polymer | 386.7 | 2 | Chemie (CLR) |
Sequence modifications
G: 1 - 182 (UniProt: P09693)
H: 1 - 9 (UniProt: P78358)
H: 121 - 218 (UniProt: P61769)
H: 326 - 593 (UniProt: H9BNV4)
| PDB | External Database | Details |
|---|---|---|
| Val 183 | - | expression tag |
| Glu 184 | - | expression tag |
| His 185 | - | expression tag |
| His 186 | - | expression tag |
| His 187 | - | expression tag |
| His 188 | - | expression tag |
| His 189 | - | expression tag |
| His 190 | - | expression tag |
| His 191 | - | expression tag |
| His 192 | - | expression tag |
| Val 193 | - | expression tag |
| Asp 194 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Val 9 | Cys 165 | engineered mutation |
| Unk 11 | - | linker |
| Unk 12 | - | linker |
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| PDB | External Database | Details |
|---|---|---|
| Unk 218 | - | linker |
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Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 9 |
| Total formula weight | 274229.7 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 586.5 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 2543.0 | |
| All* | Total formula weight | 277359.2 |
