Loading
PDBj
English日本語简体中文繁體中文한국어
✖
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help
SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9C3E

TCR - CD3 complex bound to HLA

Functional Information from GO Data
ChainGOidnamespacecontents
A0002250biological_processadaptive immune response
A0002376biological_processimmune system process
A0005886cellular_componentplasma membrane
A0009617biological_processresponse to bacterium
A0016020cellular_componentmembrane
A0042101cellular_componentT cell receptor complex
A0042105cellular_componentalpha-beta T cell receptor complex
A0046631biological_processalpha-beta T cell activation
A0050852biological_processT cell receptor signaling pathway
B0006091biological_processgeneration of precursor metabolites and energy
B0008218biological_processbioluminescence
E0004888molecular_functiontransmembrane signaling receptor activity
E0007166biological_processcell surface receptor signaling pathway
E0016020cellular_componentmembrane
F0004888molecular_functiontransmembrane signaling receptor activity
F0007166biological_processcell surface receptor signaling pathway
F0016020cellular_componentmembrane
G0004888molecular_functiontransmembrane signaling receptor activity
G0007166biological_processcell surface receptor signaling pathway
G0016020cellular_componentmembrane
H0000139cellular_componentGolgi membrane
H0001913biological_processT cell mediated cytotoxicity
H0001916biological_processpositive regulation of T cell mediated cytotoxicity
H0002237biological_processresponse to molecule of bacterial origin
H0002376biological_processimmune system process
H0002474biological_processantigen processing and presentation of peptide antigen via MHC class I
H0002481biological_processantigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
H0002502biological_processpeptide antigen assembly with MHC class I protein complex
H0002503biological_processpeptide antigen assembly with MHC class II protein complex
H0002726biological_processpositive regulation of T cell cytokine production
H0005198molecular_functionstructural molecule activity
H0005515molecular_functionprotein binding
H0005576cellular_componentextracellular region
H0005615cellular_componentextracellular space
H0005765cellular_componentlysosomal membrane
H0005783cellular_componentendoplasmic reticulum
H0005788cellular_componentendoplasmic reticulum lumen
H0005794cellular_componentGolgi apparatus
H0005829cellular_componentcytosol
H0005886cellular_componentplasma membrane
H0005925cellular_componentfocal adhesion
H0006826biological_processiron ion transport
H0006879biological_processintracellular iron ion homeostasis
H0006955biological_processimmune response
H0007608biological_processsensory perception of smell
H0007611biological_processlearning or memory
H0009897cellular_componentexternal side of plasma membrane
H0009986cellular_componentcell surface
H0010038biological_processresponse to metal ion
H0010977biological_processnegative regulation of neuron projection development
H0012507cellular_componentER to Golgi transport vesicle membrane
H0016020cellular_componentmembrane
H0019885biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I
H0019886biological_processantigen processing and presentation of exogenous peptide antigen via MHC class II
H0023026molecular_functionMHC class II protein complex binding
H0030670cellular_componentphagocytic vesicle membrane
H0031901cellular_componentearly endosome membrane
H0031902cellular_componentlate endosome membrane
H0031905cellular_componentearly endosome lumen
H0033077biological_processT cell differentiation in thymus
H0033572biological_processtransferrin transport
H0034756biological_processregulation of iron ion transport
H0034757biological_processnegative regulation of iron ion transport
H0035580cellular_componentspecific granule lumen
H0042026biological_processprotein refolding
H0042605molecular_functionpeptide antigen binding
H0042612cellular_componentMHC class I protein complex
H0042613cellular_componentMHC class II protein complex
H0042802molecular_functionidentical protein binding
H0042803molecular_functionprotein homodimerization activity
H0042824cellular_componentMHC class I peptide loading complex
H0045646biological_processregulation of erythrocyte differentiation
H0048260biological_processpositive regulation of receptor-mediated endocytosis
H0048261biological_processnegative regulation of receptor-mediated endocytosis
H0050680biological_processnegative regulation of epithelial cell proliferation
H0050768biological_processnegative regulation of neurogenesis
H0050778biological_processpositive regulation of immune response
H0050870biological_processpositive regulation of T cell activation
H0051289biological_processprotein homotetramerization
H0055038cellular_componentrecycling endosome membrane
H0060586biological_processmulticellular organismal-level iron ion homeostasis
H0070062cellular_componentextracellular exosome
H0071281biological_processcellular response to iron ion
H0071283biological_processcellular response to iron(III) ion
H0071316biological_processcellular response to nicotine
H1904724cellular_componenttertiary granule lumen
H1990000biological_processamyloid fibril formation
H1990712cellular_componentHFE-transferrin receptor complex
H2000774biological_processpositive regulation of cellular senescence
H2000978biological_processnegative regulation of forebrain neuron differentiation
X0004888molecular_functiontransmembrane signaling receptor activity
X0007166biological_processcell surface receptor signaling pathway
X0016020cellular_componentmembrane
Y0004888molecular_functiontransmembrane signaling receptor activity
Y0007166biological_processcell surface receptor signaling pathway
Y0016020cellular_componentmembrane
Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACRVNH
ChainResidueDetails
HTYR198-HIS204
HTYR581-HIS587
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues22
DetailsTransmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"27791034","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues197
DetailsDomain: {"description":"Ig-like C1-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00114","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues21
DetailsRegion: {"description":"Connecting peptide","evidences":[{"source":"PubMed","id":"27791034","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00498","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00498","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues87
DetailsTransmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues92
DetailsDomain: {"description":"Ig-like V-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00114","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues92
DetailsRegion: {"description":"T cell receptor beta variable 25-1","evidences":[{"source":"PubMed","id":"31959982","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues4
DetailsRegion: {"description":"CDR1","evidences":[{"source":"PubMed","id":"11096259","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues5
DetailsRegion: {"description":"CDR2","evidences":[{"source":"PubMed","id":"11096259","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues14
DetailsRegion: {"description":"Connecting peptide","evidences":[{"source":"UniProtKB","id":"P01850","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues91
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"8636209","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues1
DetailsModified residue: {"description":"Pyrrolidone carboxylic acid; in form pI 5.3","evidences":[{"source":"PubMed","id":"7554280","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis","evidences":[{"source":"PubMed","id":"7918443","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (Glc) (glycation) lysine; in vitro","evidences":[{"source":"PubMed","id":"7918443","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

239149

PDB entries from 2025-07-23

PDB statisticsPDBj update infoContact PDBjnumon