9C1Y
Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in complex with 7-((3-(((4-(6-aminopyridin-2-yl)butyl)amino)methyl)phenoxy)methyl)quinolin-2-amine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Nitric oxide synthase, brain | polymer | 423 | 48996.8 | 4 | UniProt (P29475) Pfam (PF02898) | Homo sapiens (human) | Constitutive NOS,NC-NOS,NOS type I,Neuronal NOS,nNOS,Peptidyl-cysteine S-nitrosylase NOS1,bNOS |
| 2 | E, J, M, R (A, B, C, D) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 4 | Chemie (HEM) | |||
| 3 | F, K, N, S (A, B, C, D) | 7-{[3-({[4-(6-aminopyridin-2-yl)butyl]amino}methyl)phenoxy]methyl}quinolin-2-amine | non-polymer | 427.5 | 4 | Chemie (V5D) | |||
| 4 | G, H, L, O, P... (A, B, C, D) | GLYCEROL | non-polymer | 92.1 | 6 | Chemie (GOL) | |||
| 5 | I, Q (B, C) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 6 | U, V, W, X (A, B, C, D) | water | water | 18.0 | 693 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 302 - 722 (UniProt: P29475)
| PDB | External Database | Details |
|---|---|---|
| Ala 354 | Arg 354 | engineered mutation |
| Asp 357 | Gly 357 | engineered mutation |
| Leu 723 | - | expression tag |
| Val 724 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 195987.1 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 4859.5 | |
| All* | Total formula weight | 200846.6 |
