9BPB

Tethered respiratory III2IV2 supercomplex from Saccharomyces cerevisiae

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, V (A, K)	Cytochrome b-c1 complex subunit 1, mitochondrial	polymer	457	50282.6	2	UniProt (P07256) Pfam (PF00675) Pfam (PF05193)	Saccharomyces cerevisiae W303	Complex III subunit 1,Core protein I,Ubiquinol-cytochrome c oxidoreductase core protein 1,Ubiquinol-cytochrome c reductase 44 kDa protein
2	B, W (B, L)	Cytochrome b-c1 complex subunit 2, mitochondrial	polymer	368	40528.0	2	UniProt (P07257) Pfam (PF00675)	Saccharomyces cerevisiae W303	Complex III subunit 2,Core protein II,Ubiquinol-cytochrome c oxidoreductase core protein 2
3	C, X (C, M)	Cytochrome b	polymer	385	43686.6	2	UniProt (P00163) Pfam (PF00033) Pfam (PF00032)	Saccharomyces cerevisiae W303	Complex III subunit 3,Complex III subunit CYTB,Complex III subunit III,Cytochrome b-c1 complex subunit 3,Cytochrome b-c1 complex subunit CYTB,Ubiquinol-cytochrome c oxidoreductase complex cytochrome b subunit
4	D, Y (D, N)	Cytochrome c1, heme protein, mitochondrial	polymer	309	34097.5	2	UniProt (P07143) Pfam (PF02167)	Saccharomyces cerevisiae W303	Complex III subunit 4,Complex III subunit IV,Cytochrome b-c1 complex subunit 4,Ubiquinol-cytochrome c oxidoreductase cytochrome c1 subunit,Cytochrome c-1
5	E, Z (E, O)	Cytochrome b-c1 complex subunit Rieske, mitochondrial	polymer	215	23394.0	2	UniProt (P08067) Pfam (PF02921) Pfam (PF00355)	Saccharomyces cerevisiae W303	Complex III subunit 5,Rieske iron-sulfur protein,RISP,Ubiquinol-cytochrome c oxidoreductase iron-sulfur subunit
6	AA, F (F, P)	Cytochrome b-c1 complex subunit 6, mitochondrial	polymer	147	17276.1	2	UniProt (P00127) Pfam (PF02320)	Saccharomyces cerevisiae W303	Complex III subunit 6,Complex III subunit VI,Cytochrome c1 non-heme 17 kDa protein,Mitochondrial hinge protein,Ubiquinol-cytochrome c oxidoreductase subunit 6,Ubiquinol-cytochrome c reductase 17 kDa protein
7	BA, G (G, Q)	Cytochrome b-c1 complex subunit 7, mitochondrial,Cytochrome c oxidase subunit 8, mitochondrial	polymer	183	20618.8	2	UniProt (P00128) UniProt (P04039) Pfam (PF02271) Pfam (PF02935)	Saccharomyces cerevisiae W303	Complex III subunit 7,Complex III subunit VII,Ubiquinol-cytochrome c oxidoreductase subunit 7,Ubiquinol-cytochrome c reductase 14 kDa protein,Cytochrome c oxidase polypeptide VIII
8	CA, H (H, R)	Cytochrome b-c1 complex subunit 8, mitochondrial	polymer	94	10987.5	2	UniProt (P08525) Pfam (PF02939)	Saccharomyces cerevisiae W303	Complex III subunit 8,Complex III subunit VII,Ubiquinol-cytochrome c oxidoreductase subunit 8,Ubiquinol-cytochrome c reductase complex 11 kDa protein,Ubiquinone-binding protein QP-C
9	DA, I (I, S)	Cytochrome b-c1 complex subunit 9, mitochondrial	polymer	66	7485.3	2	UniProt (P22289) Pfam (PF05365)	Saccharomyces cerevisiae W303	Complex III subunit 9,Complex III subunit X,Cytochrome c1 non-heme 7.3 kDa protein,Ubiquinol-cytochrome c oxidoreductase subunit 9,Ubiquinol-cytochrome c reductase 7.3 kDa protein
10	EA, J (J, T)	Cytochrome b-c1 complex subunit 10, mitochondrial	polymer	77	8602.9	2	UniProt (P37299) Pfam (PF09796)	Saccharomyces cerevisiae W303	Complex III subunit 10,Complex III subunit XI,Ubiquinol-cytochrome c oxidoreductase subunit 10,Ubiquinol-cytochrome c reductase 8.5 kDa protein
11	FA, K (a, m)	Cytochrome c oxidase subunit 1	polymer	534	58832.6	2	UniProt (P00401) Pfam (PF00115)	Saccharomyces cerevisiae W303	Cytochrome c oxidase polypeptide I
12	GA, L (b, n)	Cytochrome c oxidase subunit 2	polymer	251	28585.1	2	UniProt (P00410) Pfam (PF02790) Pfam (PF00116)	Saccharomyces cerevisiae W303	Cytochrome c oxidase polypeptide II
13	HA, M (c, o)	Cytochrome c oxidase subunit 3	polymer	269	30383.6	2	UniProt (P00420) Pfam (PF00510)	Saccharomyces cerevisiae W303	Cytochrome c oxidase polypeptide III
14	IA, N (d, p)	Cytochrome c oxidase subunit 4, mitochondrial	polymer	155	17164.6	2	UniProt (P04037) Pfam (PF01215)	Saccharomyces cerevisiae W303	Cytochrome c oxidase polypeptide IV
15	JA, O (e, q)	Cytochrome c oxidase subunit 5A, mitochondrial	polymer	153	17161.5	2	UniProt (P00424) Pfam (PF02936)	Saccharomyces cerevisiae W303	Cytochrome c oxidase polypeptide Va
16	KA, P (f, r)	Cytochrome c oxidase subunit 6, mitochondrial	polymer	148	17366.6	2	UniProt (P00427) Pfam (PF02284)	Saccharomyces cerevisiae W303	Cytochrome c oxidase polypeptide VI
17	LA, Q (g, s)	Cytochrome c oxidase subunit 7, mitochondrial	polymer	60	6942.3	2	UniProt (P10174) Pfam (PF02238)	Saccharomyces cerevisiae W303	Cytochrome c oxidase polypeptide VII
18	MA, R (i, u)	Cytochrome c oxidase subunit 9, mitochondrial	polymer	59	6974.2	2	UniProt (P07255)	Saccharomyces cerevisiae W303	Cytochrome c oxidase polypeptide VIIA
19	NA, S (j, v)	Cytochrome c oxidase subunit 12, mitochondrial	polymer	83	9799.9	2	UniProt (Q01519) Pfam (PF02297)	Saccharomyces cerevisiae W303	Cytochrome c oxidase polypeptide VIb
20	OA, T (k, w)	Cytochrome c oxidase subunit 13, mitochondrial	polymer	129	15046.1	2	UniProt (P32799) Pfam (PF02046)	Saccharomyces cerevisiae W303	Cytochrome c oxidase polypeptide VIa
21	PA, U (l, x)	Cytochrome c oxidase subunit 26, mitochondrial	polymer	66	7461.7	2	UniProt (Q2V2P9)	Saccharomyces cerevisiae W303
22	BB, DB, EB, IC, KC... (D, E, H, N, O...)	CARDIOLIPIN	non-polymer		1464.0	8	Chemie (CDL)
23	RA, ZB (C, M)	(1R)-2-(phosphonooxy)-1-[(tridecanoyloxy)methyl]ethyl pentadecanoate	non-polymer		592.8	2	Chemie (6PH)
24	AC, SA (M, C)	(2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(tetradecanoyloxy)propyl octadecanoate	non-polymer		692.0	2	Chemie (8PE)
25	TA (C)	(5S,11R)-5,8,11-trihydroxy-5,11-dioxido-17-oxo-4,6,10,12,16-pentaoxa-5,11-diphosphaoctadec-1-yl pentadecanoate	non-polymer		634.6	1	Chemie (CN5)
26	BC, FC, UA, YA (M, C)	5-(3,7,11,15,19,23-HEXAMETHYL-TETRACOSA-2,6,10,14,18,22-HEXAENYL)-2,3-DIMETHOXY-6-METHYL-BENZENE-1,4-DIOL	non-polymer		592.9	4	Chemie (UQ6)
27	CC, EC, VA, XA (M, C)	PROTOPORPHYRIN IX CONTAINING FE	non-polymer		616.5	4	Chemie (HEM)
28	DC, WA (M, C)	(1R)-2-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-1-[(heptanoyloxy)methyl]ethyl octadecanoate	non-polymer		593.8	2	Chemie (9PE)
29	GC, IB, PB, PC, WC... (N, J, a, T, m...)	DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE	non-polymer		692.0	6	Chemie (PEF)
30	AB, HC (D, N)	HEME C	non-polymer		618.5	2	Chemie (HEC)
31	CB, JC (E, O)	FE2/S2 (INORGANIC) CLUSTER	non-polymer		175.8	2	Chemie (FES)
32	DD, ED, FB, HB, MC... (w, x, H, I, R...)	1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE	non-polymer		734.0	8	Chemie (PCF)
33	AD, BD, GB, MB, NC... (n, o, I, a, S...)	PHOSPHATIDYLETHANOLAMINE	non-polymer		734.0	10	Chemie (PTY)
34	JB, LB, QC, SC (a, m)	HEME-A	non-polymer		852.8	4	Chemie (HEA)
35	KB, RC (a, m)	COPPER (II) ION	non-polymer		63.5	2	Chemie (CU)
36	NB, UC (a, m)	CALCIUM ION	non-polymer		40.1	2	Chemie (CA)
37	OB, VC (a, m)	(2R,5S,11R,14R)-5,8,11-trihydroxy-2-(nonanoyloxy)-5,11-dioxido-16-oxo-14-[(propanoyloxy)methyl]-4,6,10,12,15-pentaoxa-5,11-diphosphanonadec-1-yl undecanoate	non-polymer		834.9	2	Chemie (CN3)
38	QB, XC (b, n)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
39	SB, ZC (b, n)	DINUCLEAR COPPER ION	non-polymer		127.1	2	Chemie (CUA)
40	CD, VB (p, d)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)

Sequence modifications

G, Q: 1 - 127 (UniProt: P00128)

PDB	External Database	Details
Gly 128	-	linker
Gly 129	-	linker
Gly 130	-	linker
Gly 131	-	linker

G, Q: 132 - 183 (UniProt: P04039)

Contents of the asymmetric unit

Polymers	Number of chains	42
	Total formula weight	945355.0
Non-Polymers*	Number of molecules	67
	Total formula weight	45616.6
All*	Total formula weight	990971.5

*Water molecules are not included.