9BP8

Crystal structure of BRAF kinase domain with PF-07799933

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Serine/threonine-protein kinase B-raf	polymer	294	33200.4	1	UniProt (P15056) Pfam (PF07714)	Homo sapiens (human)	Proto-oncogene B-Raf,p94,v-Raf murine sarcoma viral oncogene homolog B1
2	B (A)	N-{(1R,2P)-6-chloro-5-[(5-chloro-3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]-4-fluorocyclohexa-2,3,5-trien-1-yl}-3-fluoroazetidine-1-sulfonamide	non-polymer		490.3	1	Chemie (A1AQY)
3	C, D, E, F (A)	DIMETHYL SULFOXIDE	non-polymer		78.1	4	Chemie (DMS)
4	G (A)	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
5	H (A)	water	water		18.0	329	Chemie (HOH)

Sequence modifications

A: 445 - 723 (UniProt: P15056)

PDB	External Database	Details
Met 430	-	initiating methionine
Gly 431	-	expression tag
His 432	-	expression tag
His 433	-	expression tag
His 434	-	expression tag
His 435	-	expression tag
His 436	-	expression tag
His 437	-	expression tag
Gly 438	-	expression tag
Leu 439	-	expression tag
Val 440	-	expression tag
Pro 441	-	expression tag
Arg 442	-	expression tag
Gly 443	-	expression tag
Ser 444	-	expression tag
Ala 667	Phe 667	engineered mutation
Ala 671	Arg 671	engineered mutation
Ala 673	Tyr 673	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	33200.4
Non-Polymers*	Number of molecules	6
	Total formula weight	898.9
All*	Total formula weight	34099.3

*Water molecules are not included.