9BOY

Cryo-EM structure of human Glycine Receptor apha3-beta heteromer with glycine in nanodisc

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Glycine receptor subunit alpha-3	polymer	422	48936.5	4	UniProt (O75311) Pfam (PF02931) Pfam (PF02932)	Homo sapiens (human)
2	E (E)	Glycine receptor subunit beta,Green fluorescent protein	polymer	680	76584.5	1	UniProt (P48167) UniProt (A0A9X4KGN5) Pfam (PF02931) Pfam (PF02932)	Homo sapiens (human)	Glycine receptor 58 kDa subunit
3	F, I, K, M, O (A, B, C, D, E)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	5	Chemie (NAG)
4	G, H, J, L, N (A, B, C, D)	GLYCINE	non-polymer		75.1	5	Chemie (GLY)

Sequence modifications

A, B, C, D: 1 - 431 (UniProt: O75311)

PDB	External Database	Details
-	Ala 362	deletion
-	Leu 363	deletion
-	Glu 364	deletion
-	Lys 365	deletion
-	Phe 366	deletion
-	Tyr 367	deletion
-	Arg 368	deletion
-	Phe 369	deletion
-	Ser 370	deletion

E: 3 - 333 (UniProt: P48167)
E: 333 - 342 (UniProt: A0A9X4KGN5)

PDB	External Database	Details
Phe 335	Leu 72	conflict
Ser 335	Thr 73	conflict
His 342	Leu 239	conflict
Ser 342	-	linker
Gly 342	-	linker
Ser 342	-	linker
Gly 342	-	linker

E: 342 - 475 (UniProt: P48167)

PDB	External Database	Details
Gly 333	-	linker
Gly 333	-	linker
Ser 333	-	linker
Ser 333	-	linker
Ala 333	-	linker
Ala 333	-	linker
Ala 333	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	272330.6
Non-Polymers*	Number of molecules	10
	Total formula weight	1481.4
All*	Total formula weight	273812.0

*Water molecules are not included.