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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9BOY

Cryo-EM structure of human Glycine Receptor apha3-beta heteromer with glycine in nanodisc

Functional Information from GO Data
ChainGOidnamespacecontents
A0004888molecular_functiontransmembrane signaling receptor activity
A0005216molecular_functionmonoatomic ion channel activity
A0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
A0005231molecular_functionexcitatory extracellular ligand-gated monoatomic ion channel activity
A0005254molecular_functionchloride channel activity
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006821biological_processchloride transport
A0016020cellular_componentmembrane
A0016594molecular_functionglycine binding
A0016934molecular_functionextracellularly glycine-gated chloride channel activity
A0016935cellular_componentglycine-gated chloride channel complex
A0022824molecular_functiontransmitter-gated monoatomic ion channel activity
A0022852molecular_functionglycine-gated chloride ion channel activity
A0030425cellular_componentdendrite
A0034220biological_processmonoatomic ion transmembrane transport
A0034707cellular_componentchloride channel complex
A0042734cellular_componentpresynaptic membrane
A0043204cellular_componentperikaryon
A0045202cellular_componentsynapse
A0045211cellular_componentpostsynaptic membrane
A0046872molecular_functionmetal ion binding
A0051260biological_processprotein homooligomerization
A0060079biological_processexcitatory postsynaptic potential
A0098690cellular_componentglycinergic synapse
A0099171biological_processpresynaptic modulation of chemical synaptic transmission
A1902476biological_processchloride transmembrane transport
B0004888molecular_functiontransmembrane signaling receptor activity
B0005216molecular_functionmonoatomic ion channel activity
B0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
B0005231molecular_functionexcitatory extracellular ligand-gated monoatomic ion channel activity
B0005254molecular_functionchloride channel activity
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006821biological_processchloride transport
B0016020cellular_componentmembrane
B0016594molecular_functionglycine binding
B0016934molecular_functionextracellularly glycine-gated chloride channel activity
B0016935cellular_componentglycine-gated chloride channel complex
B0022824molecular_functiontransmitter-gated monoatomic ion channel activity
B0022852molecular_functionglycine-gated chloride ion channel activity
B0030425cellular_componentdendrite
B0034220biological_processmonoatomic ion transmembrane transport
B0034707cellular_componentchloride channel complex
B0042734cellular_componentpresynaptic membrane
B0043204cellular_componentperikaryon
B0045202cellular_componentsynapse
B0045211cellular_componentpostsynaptic membrane
B0046872molecular_functionmetal ion binding
B0051260biological_processprotein homooligomerization
B0060079biological_processexcitatory postsynaptic potential
B0098690cellular_componentglycinergic synapse
B0099171biological_processpresynaptic modulation of chemical synaptic transmission
B1902476biological_processchloride transmembrane transport
C0004888molecular_functiontransmembrane signaling receptor activity
C0005216molecular_functionmonoatomic ion channel activity
C0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
C0005231molecular_functionexcitatory extracellular ligand-gated monoatomic ion channel activity
C0005254molecular_functionchloride channel activity
C0005515molecular_functionprotein binding
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0006821biological_processchloride transport
C0016020cellular_componentmembrane
C0016594molecular_functionglycine binding
C0016934molecular_functionextracellularly glycine-gated chloride channel activity
C0016935cellular_componentglycine-gated chloride channel complex
C0022824molecular_functiontransmitter-gated monoatomic ion channel activity
C0022852molecular_functionglycine-gated chloride ion channel activity
C0030425cellular_componentdendrite
C0034220biological_processmonoatomic ion transmembrane transport
C0034707cellular_componentchloride channel complex
C0042734cellular_componentpresynaptic membrane
C0043204cellular_componentperikaryon
C0045202cellular_componentsynapse
C0045211cellular_componentpostsynaptic membrane
C0046872molecular_functionmetal ion binding
C0051260biological_processprotein homooligomerization
C0060079biological_processexcitatory postsynaptic potential
C0098690cellular_componentglycinergic synapse
C0099171biological_processpresynaptic modulation of chemical synaptic transmission
C1902476biological_processchloride transmembrane transport
D0004888molecular_functiontransmembrane signaling receptor activity
D0005216molecular_functionmonoatomic ion channel activity
D0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
D0005231molecular_functionexcitatory extracellular ligand-gated monoatomic ion channel activity
D0005254molecular_functionchloride channel activity
D0005515molecular_functionprotein binding
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006821biological_processchloride transport
D0016020cellular_componentmembrane
D0016594molecular_functionglycine binding
D0016934molecular_functionextracellularly glycine-gated chloride channel activity
D0016935cellular_componentglycine-gated chloride channel complex
D0022824molecular_functiontransmitter-gated monoatomic ion channel activity
D0022852molecular_functionglycine-gated chloride ion channel activity
D0030425cellular_componentdendrite
D0034220biological_processmonoatomic ion transmembrane transport
D0034707cellular_componentchloride channel complex
D0042734cellular_componentpresynaptic membrane
D0043204cellular_componentperikaryon
D0045202cellular_componentsynapse
D0045211cellular_componentpostsynaptic membrane
D0046872molecular_functionmetal ion binding
D0051260biological_processprotein homooligomerization
D0060079biological_processexcitatory postsynaptic potential
D0098690cellular_componentglycinergic synapse
D0099171biological_processpresynaptic modulation of chemical synaptic transmission
D1902476biological_processchloride transmembrane transport
E0004888molecular_functiontransmembrane signaling receptor activity
E0005216molecular_functionmonoatomic ion channel activity
E0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
E0006091biological_processgeneration of precursor metabolites and energy
E0006811biological_processmonoatomic ion transport
E0008218biological_processbioluminescence
E0016020cellular_componentmembrane
E0034220biological_processmonoatomic ion transmembrane transport
Functional Information from PROSITE/UniProt
site_idPS00236
Number of Residues15
DetailsNEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CpLdLtlFPmDtqrC
ChainResidueDetails
ECYS161-CYS175
ACYS138-CYS152
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues84
DetailsTransmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"26416729","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues16
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"26416729","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"26416729","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues40
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"26416729","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"26416729","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"26416729","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P23415","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues20
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"26416729","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues4
DetailsSite: {"description":"Important for obstruction of the ion pore in the closed conformation","evidences":[{"source":"PubMed","id":"26416729","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"26416729","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5CFB","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues20
DetailsTransmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"34473954","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5BKF","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues4
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"34473954","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5BKF","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues20
DetailsTransmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"34473954","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5BKF","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues11
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"34473954","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5BKF","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues21
DetailsTransmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"34473954","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5BKF","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues23
DetailsTransmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"34473954","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5BKF","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"34473954","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37821459","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5BKF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DN5","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"34473954","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5BKF","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues1
DetailsSite: {"description":"Important for obstruction of the ion pore in the closed conformation","evidences":[{"source":"UniProtKB","id":"P23415","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"34473954","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

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PDB entries from 2026-01-07

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