9BOL

Crystal structure of the complex between VHL, ElonginB, ElonginC, and compound 5

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D	Elongin-B	polymer	104	11748.4	2	UniProt (Q15370) Pfam (PF00240) In PDB	Homo sapiens (human)	EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2
2	B, E	Elongin-C	polymer	96	10843.4	2	UniProt (Q15369) Pfam (PF03931) In PDB	Homo sapiens (human)	EloC, Elongin 15 kDa subunit, RNA polymerase II transcription factor SIII subunit C, SIII p15, Transcription elongation factor B polypeptide 1
3	C, F	von Hippel-Lindau disease tumor suppressor	polymer	176	20514.3	2	UniProt (P40337) Pfam (PF01847) Pfam (PF17211) In PDB	Homo sapiens (human)	Protein G7,pVHL
4	B, C, E, F	1,2-ETHANEDIOL	non-polymer		62.1	5	Chemie (EDO)
5	C, E	DIMETHYL SULFOXIDE	non-polymer		78.1	2	Chemie (DMS)
6	C, F	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
7	C, F	(4R)-1-[(2S)-2-(4-cyclopropyl-1H-1,2,3-triazol-1-yl)-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}-L-prolinamide	non-polymer		522.7	2	Chemie (A1ARP)
8		water	water		18.0	349	Chemie (HOH)

Sequence modifications

C, F: 54 - 213 (UniProt: P40337)

PDB	External Database	Details
Met 38	-	initiating methionine
His 39	-	expression tag
His 40	-	expression tag
His 41	-	expression tag
His 42	-	expression tag
His 43	-	expression tag
His 44	-	expression tag
Gly 45	-	expression tag
Glu 46	-	expression tag
Asn 47	-	expression tag
Leu 48	-	expression tag
Tyr 49	-	expression tag
Phe 50	-	expression tag
Gln 51	-	expression tag
Gly 52	-	expression tag
Ser 53	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	86212.2
Non-Polymers*	Number of molecules	11
	Total formula weight	1582.8
All*	Total formula weight	87795.0

*Water molecules are not included.