9BOL
Crystal structure of the complex between VHL, ElonginB, ElonginC, and compound 5
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (A, D) | Elongin-B | polymer | 104 | 11748.4 | 2 | UniProt (Q15370) Pfam (PF00240) | Homo sapiens (human) | EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2 |
| 2 | B, E (B, E) | Elongin-C | polymer | 96 | 10843.4 | 2 | UniProt (Q15369) Pfam (PF03931) | Homo sapiens (human) | EloC, Elongin 15 kDa subunit, RNA polymerase II transcription factor SIII subunit C, SIII p15, Transcription elongation factor B polypeptide 1 |
| 3 | C, F (C, F) | von Hippel-Lindau disease tumor suppressor | polymer | 176 | 20514.3 | 2 | UniProt (P40337) Pfam (PF01847) Pfam (PF17211) | Homo sapiens (human) | Protein G7,pVHL |
| 4 | G, H, I, M, O (B, C, E, F) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 5 | J, N (C, E) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 2 | Chemie (DMS) | |||
| 6 | K, P (C, F) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 7 | L, Q (C, F) | (4R)-1-[(2S)-2-(4-cyclopropyl-1H-1,2,3-triazol-1-yl)-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}-L-prolinamide | non-polymer | 522.7 | 2 | Chemie (A1ARP) | |||
| 8 | R, S, T, U, V... (A, B, C, D, E...) | water | water | 18.0 | 349 | Chemie (HOH) |
Sequence modifications
C, F: 54 - 213 (UniProt: P40337)
| PDB | External Database | Details |
|---|---|---|
| Met 38 | - | initiating methionine |
| His 39 | - | expression tag |
| His 40 | - | expression tag |
| His 41 | - | expression tag |
| His 42 | - | expression tag |
| His 43 | - | expression tag |
| His 44 | - | expression tag |
| Gly 45 | - | expression tag |
| Glu 46 | - | expression tag |
| Asn 47 | - | expression tag |
| Leu 48 | - | expression tag |
| Tyr 49 | - | expression tag |
| Phe 50 | - | expression tag |
| Gln 51 | - | expression tag |
| Gly 52 | - | expression tag |
| Ser 53 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 86212.2 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1582.8 | |
| All* | Total formula weight | 87795.0 |
