9BJK

Inactive mu opioid receptor bound to Nb6, naloxone and NAM

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (N)	kappa opioid receptor Nanobody 6	polymer	133	14730.3	1		Lama glama
2	B (R)	Mu-type opioid receptor	polymer	426	47920.7	1	UniProt (P42866) Pfam (PF00001)	Mus musculus (house mouse)	M-OR-1,MOR-1
3	C (R)	Naloxone	non-polymer		327.4	1	Chemie (A1APV)
4	D (R)	Nalpha-[({(1M)-1-[5-(benzyloxy)pyridin-3-yl]naphthalen-2-yl}sulfanyl)acetyl]-3-methoxy-N,4-dimethyl-L-phenylalaninamide	non-polymer		605.7	1	Chemie (A1APU)

Sequence modifications

R: 6 - 398 (UniProt: P42866)

PDB	External Database	Details
Met -19	-	initiating methionine
Lys -18	-	expression tag
Thr -17	-	expression tag
Ile -16	-	expression tag
Ile -15	-	expression tag
Ala -14	-	expression tag
Leu -13	-	expression tag
Ser -12	-	expression tag
Tyr -11	-	expression tag
Ile -10	-	expression tag
Phe -9	-	expression tag
Cys -8	-	expression tag
Leu -7	-	expression tag
Val -6	-	expression tag
Phe -5	-	expression tag
Ala -4	-	expression tag
Asp -3	-	expression tag
Tyr -2	-	expression tag
Lys -1	-	expression tag
Asp 0	-	expression tag
Asp 1	-	expression tag
Asp 2	-	expression tag
Asp 3	-	expression tag
Ala 4	-	expression tag
Met 5	-	expression tag
Leu 264	Met 264	engineered mutation
Arg 269	Lys 269	engineered mutation
Asp 399	-	expression tag
Ile 400	-	expression tag
His 401	-	expression tag
His 402	-	expression tag
His 403	-	expression tag
His 404	-	expression tag
His 405	-	expression tag
His 406	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	62651.0
Non-Polymers*	Number of molecules	2
	Total formula weight	933.1
All*	Total formula weight	63584.1

*Water molecules are not included.