9BJK
Inactive mu opioid receptor bound to Nb6, naloxone and NAM
This is a non-PDB format compatible entry.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| R | 0001965 | molecular_function | G-protein alpha-subunit binding |
| R | 0004930 | molecular_function | G protein-coupled receptor activity |
| R | 0004979 | molecular_function | beta-endorphin receptor activity |
| R | 0004985 | molecular_function | G protein-coupled opioid receptor activity |
| R | 0005515 | molecular_function | protein binding |
| R | 0005768 | cellular_component | endosome |
| R | 0005886 | cellular_component | plasma membrane |
| R | 0007165 | biological_process | signal transduction |
| R | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| R | 0007191 | biological_process | adenylate cyclase-activating dopamine receptor signaling pathway |
| R | 0007193 | biological_process | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway |
| R | 0007197 | biological_process | adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway |
| R | 0007200 | biological_process | phospholipase C-activating G protein-coupled receptor signaling pathway |
| R | 0007218 | biological_process | neuropeptide signaling pathway |
| R | 0007626 | biological_process | locomotory behavior |
| R | 0016020 | cellular_component | membrane |
| R | 0019226 | biological_process | transmission of nerve impulse |
| R | 0019233 | biological_process | sensory perception of pain |
| R | 0030424 | cellular_component | axon |
| R | 0030425 | cellular_component | dendrite |
| R | 0031681 | molecular_function | G-protein beta-subunit binding |
| R | 0038003 | biological_process | G protein-coupled opioid receptor signaling pathway |
| R | 0038047 | molecular_function | morphine receptor activity |
| R | 0042923 | molecular_function | neuropeptide binding |
| R | 0042995 | cellular_component | cell projection |
| R | 0043005 | cellular_component | neuron projection |
| R | 0043204 | cellular_component | perikaryon |
| R | 0045019 | biological_process | negative regulation of nitric oxide biosynthetic process |
| R | 0050769 | biological_process | positive regulation of neurogenesis |
| R | 0051481 | biological_process | negative regulation of cytosolic calcium ion concentration |
| R | 0061358 | biological_process | negative regulation of Wnt protein secretion |
| R | 0070374 | biological_process | positive regulation of ERK1 and ERK2 cascade |
| R | 0071315 | biological_process | cellular response to morphine |
| R | 0098793 | cellular_component | presynapse |
| R | 0098982 | cellular_component | GABA-ergic synapse |
| R | 0099171 | biological_process | presynaptic modulation of chemical synaptic transmission |
| R | 2000310 | biological_process | regulation of NMDA receptor activity |
Functional Information from PROSITE/UniProt
| site_id | PS00237 |
| Number of Residues | 17 |
| Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. TSIfTLCTMSVDRYIaV |
| Chain | Residue | Details |
| R | THR153-VAL169 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:22437502, ECO:0000269|PubMed:26245379 |
| Chain | Residue | Details |
| R | THR67-TYR91 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 115 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:22437502, ECO:0000269|PubMed:26245379 |
| Chain | Residue | Details |
| R | VAL92-ASN104 | |
| R | ASP164-ASN183 | |
| R | LEU254-ARG277 | |
| R | ALA337-PRO398 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:22437502, ECO:0000269|PubMed:26245379 |
| Chain | Residue | Details |
| R | ILE105-LEU129 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 39 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:22437502, ECO:0000269|PubMed:26245379 |
| Chain | Residue | Details |
| R | MET130-CYS140 | |
| R | ALA206-TRP228 | |
| R | LEU305-THR312 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:22437502, ECO:0000269|PubMed:26245379 |
| Chain | Residue | Details |
| R | LYS141-VAL163 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:22437502, ECO:0000269|PubMed:26245379 |
| Chain | Residue | Details |
| R | ALA184-MET205 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:22437502, ECO:0000269|PubMed:26245379 |
| Chain | Residue | Details |
| R | GLU229-GLY253 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 26 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:22437502, ECO:0000269|PubMed:26245379 |
| Chain | Residue | Details |
| R | ILE278-ALA304 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:22437502, ECO:0000269|PubMed:26245379 |
| Chain | Residue | Details |
| R | PHE313-TYR336 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P33535 |
| Chain | Residue | Details |
| R | TYR166 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:21183079 |
| Chain | Residue | Details |
| R | SER363 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P33535 |
| Chain | Residue | Details |
| R | THR370 | |
| R | THR394 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P33535 |
| Chain | Residue | Details |
| R | SER375 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000255 |
| Chain | Residue | Details |
| R | CYS351 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| R | ASN9 | |
| R | ASN31 | |
| R | ASN38 | |
| R | ASN46 |
