9BJG

Crystal structure of broadly neutralizing human monoclonal antibody 75B10 in complex with AMA1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Apical membrane antigen 1	polymer	347	39655.5	1	UniProt (Q7KQK5) UniProt (by SIFTS) (P22621)	Plasmodium falciparum 3D7	Merozoite surface antigen
2	B (H)	75B10 Fab Heavy Chain	polymer	247	26511.7	1		Homo sapiens (human)
3	C (L)	75B10 Fab Light Chain	polymer	217	23800.4	1		Homo sapiens (human)
4	D, E, F (A, H, L)	water	water		18.0	15	Chemie (HOH)

Sequence modifications

A: 104 - 438 (UniProt: Q7KQK5)

PDB	External Database	Details
Glu 101	-	expression tag
Thr 102	-	expression tag
Gly 103	-	expression tag
Ala 164	Thr 164	engineered mutation
Ala 288	Thr 288	engineered mutation
Ala 373	Ser 373	engineered mutation
Ala 423	Ser 423	engineered mutation
Ala 424	Ser 424	engineered mutation
Gly 439	-	expression tag
Thr 440	-	expression tag
Lys 441	-	expression tag
His 442	-	expression tag
His 443	-	expression tag
His 444	-	expression tag
His 445	-	expression tag
His 446	-	expression tag
His 447	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	89967.6
All*	Total formula weight	89967.6

*Water molecules are not included.