Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Mitogen-activated protein kinase kinase kinase kinase 1 | polymer | 311 | 35018.4 | 2 | UniProt (Q92918) Pfam (PF00069) | Homo sapiens (human) | Hematopoietic progenitor kinase,MAPK/ERK kinase kinase kinase 1,MEK kinase kinase 1,MEKKK 1 |
| 2 | C, E (A, B) | (3R,4S)-4-methyloxolan-3-yl [(6P)-8-amino-7-fluoro-6-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)isoquinolin-3-yl]carbamate | non-polymer | 453.5 | 2 | Chemie (A1APL) | |||
| 3 | D (B) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 4 | F (B) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 5 | G, H (A, B) | water | water | 18.0 | 145 | Chemie (HOH) |
Sequence modifications
A, B: 2 - 293 (UniProt: Q92918)
| PDB | External Database | Details |
|---|---|---|
| Met -14 | - | initiating methionine |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| His -10 | - | expression tag |
| His -9 | - | expression tag |
| His -8 | - | expression tag |
| Gly -7 | - | expression tag |
| Glu -6 | - | expression tag |
| Asn -5 | - | expression tag |
| Leu -4 | - | expression tag |
| Tyr -3 | - | expression tag |
| Phe -2 | - | expression tag |
| Gln -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Ser 1 | - | expression tag |
| Glu 165 | Thr 165 | conflict |
| Glu 171 | Ser 171 | conflict |
| Gly 294 | - | expression tag |
| Asn 295 | - | expression tag |
| Ser 296 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 70036.9 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1008.1 | |
| All* | Total formula weight | 71044.9 |
