9BF9
Human LAG-3-HLA-DR1 complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | HLA class II histocompatibility antigen, DR alpha chain | polymer | 189 | 21919.6 | 1 | UniProt (P01903) Pfam (PF00993) Pfam (PF07654) | Homo sapiens (human) | MHC class II antigen DRA |
| 2 | B (B) | HLA class II histocompatibility antigen DR beta chain | polymer | 211 | 24033.5 | 1 | UniProt (D7RIG0) | Homo sapiens (human) | HLA-DRB1 protein,MHC class II antigen |
| 3 | C (G) | Membrane protein | polymer | 13 | 1401.6 | 1 | UniProt (P0DTC5) | Severe acute respiratory syndrome coronavirus 2 | M,E1 glycoprotein,Matrix glycoprotein,Membrane glycoprotein |
| 4 | D (D) | Lymphocyte activation gene 3 protein | polymer | 418 | 45338.3 | 1 | UniProt (P18627) | Homo sapiens (human) | LAG-3 |
| 5 | E (C) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G22768VO) | |||
| 6 | F, I, J (A, D) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 7 | G (D) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 8 | H (D) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) |
Sequence modifications
A: 5 - 181 (UniProt: P01903)
B: 0 - 198 (UniProt: D7RIG0)
D: 1 - 407 (UniProt: P18627)
| PDB | External Database | Details |
|---|---|---|
| Ile 1 | - | expression tag |
| Lys 2 | - | expression tag |
| Glu 3 | - | expression tag |
| Glu 4 | - | expression tag |
| Thr 182 | - | expression tag |
| Ser 183 | - | expression tag |
| Gly 184 | - | expression tag |
| Asp 185 | - | expression tag |
| Asp 186 | - | expression tag |
| Asp 187 | - | expression tag |
| Asp 188 | - | expression tag |
| Lys 189 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Asp -12 | - | expression tag |
| Ser -11 | - | expression tag |
| Gly -10 | - | expression tag |
| Gly -9 | - | expression tag |
| Ser -8 | - | expression tag |
| Gly -7 | - | expression tag |
| Ser -6 | - | expression tag |
| Ile -5 | - | expression tag |
| Glu -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Arg -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | Ala 29 | conflict |
| Thr 191 | Arg 220 | conflict |
| Gly 192 | Ser 221 | conflict |
| Gly 193 | Glu 222 | conflict |
| Asp 194 | Ser 223 | conflict |
| Asp 195 | Ala 224 | conflict |
| Asp 196 | Gln 225 | conflict |
| Asp 197 | Ser 226 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Thr 408 | - | expression tag |
| Gly 409 | - | expression tag |
| Gly 410 | - | expression tag |
| Leu 411 | - | expression tag |
| Glu 412 | - | expression tag |
| Val 413 | - | expression tag |
| Leu 414 | - | expression tag |
| Phe 415 | - | expression tag |
| Gln 416 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 92693.0 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 910.8 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 615.5 | |
| All* | Total formula weight | 94219.3 |
