9B9G

Structure of the PI4KA complex bound to Calcineurin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Phosphatidylinositol 4-kinase alpha	polymer	2102	237102.3	2	UniProt (P42356) Pfam (PF19274) Pfam (PF00613) Pfam (PF00454)	Homo sapiens (human)	PI4-kinase alpha,PI4K-alpha,PtdIns-4-kinase alpha,Phosphatidylinositol 4-Kinase III alpha
2	C, E (D, F)	Tetratricopeptide repeat protein 7B	polymer	843	94294.1	2	UniProt (Q86TV6) Pfam (PF19440) Pfam (PF13181) Pfam (PF12895) Pfam (PF13424)	Homo sapiens (human)	TPR repeat protein 7B,Tetratricopeptide repeat protein 7-like-1,TPR repeat protein 7-like-1
3	D, F (E, G)	Hyccin	polymer	308	34638.9	2	UniProt (Q9BYI3) Pfam (PF09790)	Homo sapiens (human)	Down-regulated by CTNNB1 protein A
4	G, I (H, J)	Calcineurin subunit B type 1	polymer	170	19322.9	2	UniProt (P63098) Pfam (PF13499)	Homo sapiens (human)	Protein phosphatase 2B regulatory subunit 1,Protein phosphatase 3 regulatory subunit B alpha isoform 1
5	H, J (I, K)	Protein phosphatase 3 catalytic subunit alpha	polymer	620	70883.2	2	UniProt (Q08209) Pfam (PF00149)	Homo sapiens (human)	CAM-PRP catalytic subunit,Calcineurin A alpha,Calmodulin-dependent calcineurin A subunit alpha isoform,CNA alpha,Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
6	K, L, M, N, O... (H, J)	CALCIUM ION	non-polymer		40.1	8	Chemie (CA)

Sequence modifications

I, K: 2 - 391 (UniProt: Q08209)

PDB	External Database	Details
Pro 236	Leu 236	engineered mutation
Asn 238	Asp 238	engineered mutation

I, K: 392 - 621 (UniProt: Q08209)

PDB	External Database	Details
Pro 466	Leu 236	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	10
	Total formula weight	912482.8
Non-Polymers*	Number of molecules	8
	Total formula weight	320.6
All*	Total formula weight	912803.4

*Water molecules are not included.