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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9B9G

Structure of the PI4KA complex bound to Calcineurin

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0004430molecular_function1-phosphatidylinositol 4-kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005925cellular_componentfocal adhesion
A0006629biological_processlipid metabolic process
A0006661biological_processphosphatidylinositol biosynthetic process
A0007165biological_processsignal transduction
A0016020cellular_componentmembrane
A0016301molecular_functionkinase activity
A0016740molecular_functiontransferase activity
A0030660cellular_componentGolgi-associated vesicle membrane
A0044788biological_processhost-mediated perturbation of viral process
A0045296molecular_functioncadherin binding
A0046854biological_processphosphatidylinositol phosphate biosynthetic process
A0048015biological_processphosphatidylinositol-mediated signaling
A0070062cellular_componentextracellular exosome
A0140754biological_processreorganization of cellular membranes to establish viral sites of replication
B0000166molecular_functionnucleotide binding
B0004430molecular_function1-phosphatidylinositol 4-kinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005925cellular_componentfocal adhesion
B0006629biological_processlipid metabolic process
B0006661biological_processphosphatidylinositol biosynthetic process
B0007165biological_processsignal transduction
B0016020cellular_componentmembrane
B0016301molecular_functionkinase activity
B0016740molecular_functiontransferase activity
B0030660cellular_componentGolgi-associated vesicle membrane
B0044788biological_processhost-mediated perturbation of viral process
B0045296molecular_functioncadherin binding
B0046854biological_processphosphatidylinositol phosphate biosynthetic process
B0048015biological_processphosphatidylinositol-mediated signaling
B0070062cellular_componentextracellular exosome
B0140754biological_processreorganization of cellular membranes to establish viral sites of replication
D0005515molecular_functionprotein binding
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0046854biological_processphosphatidylinositol phosphate biosynthetic process
D0072659biological_processprotein localization to plasma membrane
F0005515molecular_functionprotein binding
F0005829cellular_componentcytosol
F0005886cellular_componentplasma membrane
F0046854biological_processphosphatidylinositol phosphate biosynthetic process
F0072659biological_processprotein localization to plasma membrane
H0004721molecular_functionphosphoprotein phosphatase activity
H0004723molecular_functioncalcium-dependent protein serine/threonine phosphatase activity
H0005509molecular_functioncalcium ion binding
H0005515molecular_functionprotein binding
H0005516molecular_functioncalmodulin binding
H0005654cellular_componentnucleoplasm
H0005829cellular_componentcytosol
H0005886cellular_componentplasma membrane
H0005955cellular_componentcalcineurin complex
H0008597molecular_functioncalcium-dependent protein serine/threonine phosphatase regulator activity
H0019902molecular_functionphosphatase binding
H0019904molecular_functionprotein domain specific binding
H0033173biological_processcalcineurin-NFAT signaling cascade
H0042383cellular_componentsarcolemma
H0045202cellular_componentsynapse
H0045944biological_processpositive regulation of transcription by RNA polymerase II
H0046872molecular_functionmetal ion binding
H0070886biological_processpositive regulation of calcineurin-NFAT signaling cascade
H0098685cellular_componentSchaffer collateral - CA1 synapse
H0098686cellular_componenthippocampal mossy fiber to CA3 synapse
H0098688cellular_componentparallel fiber to Purkinje cell synapse
H0098693biological_processregulation of synaptic vesicle cycle
H0098794cellular_componentpostsynapse
H0098978cellular_componentglutamatergic synapse
H0099149biological_processregulation of postsynaptic neurotransmitter receptor internalization
H0099170biological_processpostsynaptic modulation of chemical synaptic transmission
H1905665biological_processpositive regulation of calcium ion import across plasma membrane
H1905949biological_processnegative regulation of calcium ion import across plasma membrane
I0016787molecular_functionhydrolase activity
I0033192molecular_functioncalmodulin-dependent protein phosphatase activity
I0097720biological_processcalcineurin-mediated signaling
J0004721molecular_functionphosphoprotein phosphatase activity
J0004723molecular_functioncalcium-dependent protein serine/threonine phosphatase activity
J0005509molecular_functioncalcium ion binding
J0005515molecular_functionprotein binding
J0005516molecular_functioncalmodulin binding
J0005654cellular_componentnucleoplasm
J0005829cellular_componentcytosol
J0005886cellular_componentplasma membrane
J0005955cellular_componentcalcineurin complex
J0008597molecular_functioncalcium-dependent protein serine/threonine phosphatase regulator activity
J0019902molecular_functionphosphatase binding
J0019904molecular_functionprotein domain specific binding
J0033173biological_processcalcineurin-NFAT signaling cascade
J0042383cellular_componentsarcolemma
J0045202cellular_componentsynapse
J0045944biological_processpositive regulation of transcription by RNA polymerase II
J0046872molecular_functionmetal ion binding
J0070886biological_processpositive regulation of calcineurin-NFAT signaling cascade
J0098685cellular_componentSchaffer collateral - CA1 synapse
J0098686cellular_componenthippocampal mossy fiber to CA3 synapse
J0098688cellular_componentparallel fiber to Purkinje cell synapse
J0098693biological_processregulation of synaptic vesicle cycle
J0098794cellular_componentpostsynapse
J0098978cellular_componentglutamatergic synapse
J0099149biological_processregulation of postsynaptic neurotransmitter receptor internalization
J0099170biological_processpostsynaptic modulation of chemical synaptic transmission
J1905665biological_processpositive regulation of calcium ion import across plasma membrane
J1905949biological_processnegative regulation of calcium ion import across plasma membrane
K0016787molecular_functionhydrolase activity
K0033192molecular_functioncalmodulin-dependent protein phosphatase activity
K0097720biological_processcalcineurin-mediated signaling
Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DLDNSGSLSveEF
ChainResidueDetails
HASP31-PHE43
HASP63-PHE75
HASP100-LEU112
HASP141-PHE153
site_idPS00063
Number of Residues16
DetailsALDOKETO_REDUCTASE_3 Aldo/keto reductase family putative active site signature. LARSLAvqRPaSLeKV
ChainResidueDetails
ALEU38-VAL53
site_idPS00125
Number of Residues6
DetailsSER_THR_PHOSPHATASE Serine/threonine specific protein phosphatases signature. LRGNHE
ChainResidueDetails
ILEU147-GLU152
site_idPS00915
Number of Residues15
DetailsPI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. FKvg.DDCRQDmlalQ
ChainResidueDetails
APHE1849-GLN1863
site_idPS00916
Number of Residues21
DetailsPI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. SmAaysLllFLLqIkDRHngN
ChainResidueDetails
ASER1942-ASN1962
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues376
DetailsDomain: {"description":"PIK helical","evidences":[{"source":"PROSITE-ProRule","id":"PRU00878","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues12
DetailsRegion: {"description":"G-loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues16
DetailsRegion: {"description":"Catalytic loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues66
DetailsRepeat: {"description":"TPR 2"}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues66
DetailsRepeat: {"description":"TPR 3"}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues66
DetailsRepeat: {"description":"TPR 4"}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues70
DetailsRepeat: {"description":"TPR 5"}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues64
DetailsRepeat: {"description":"TPR 6"}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues66
DetailsRepeat: {"description":"TPR 7"}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues66
DetailsRepeat: {"description":"TPR 8"}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues66
DetailsRepeat: {"description":"TPR 9"}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues64
DetailsRepeat: {"description":"TPR 10"}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues66
DetailsRepeat: {"description":"TPR 11"}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues56
DetailsDomain: {"description":"EF-hand 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues70
DetailsDomain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues70
DetailsDomain: {"description":"EF-hand 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues70
DetailsDomain: {"description":"EF-hand 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues10
DetailsRegion: {"description":"Calcineurin A binding","evidences":[{"source":"PubMed","id":"12218175","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12357034","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17498738","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22343722","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23468591","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26794871","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27974827","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8524402","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues30
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"12218175","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12357034","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17498738","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22343722","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23468591","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26794871","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27974827","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8524402","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1AUI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1M63","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1MF8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2P6B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LL8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F0Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OR9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ORA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ORC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVE","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues10
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"12218175","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12357034","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17498738","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22343722","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23468591","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26794871","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27974827","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31375679","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8524402","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6NUC","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"1AUI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1M63","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1MF8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2P6B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LL8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F0Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OR9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ORA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ORC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVE","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues4
DetailsSite: {"description":"Interaction with PxVP motif in substrates of the catalytic subunit","evidences":[{"source":"PubMed","id":"23468591","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q63810","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues18
DetailsRegion: {"description":"Interaction with PxIxIF motif in substrate","evidences":[{"source":"PubMed","id":"17498738","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17502104","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22343722","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23468591","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26248042","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues56
DetailsRegion: {"description":"Calcineurin B binding","evidences":[{"source":"PubMed","id":"12218175","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12357034","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17498738","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23468591","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27974827","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8524402","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI26
Number of Residues8
DetailsMotif: {"description":"SAPNY motif","evidences":[{"source":"PubMed","id":"26248042","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI27
Number of Residues2
DetailsActive site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"8524402","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI28
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"12218175","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17498738","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22343722","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26248042","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27974827","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31375679","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8524402","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1AUI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1M63","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2P6B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LL8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5C1V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NUC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NUU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UUQ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI29
Number of Residues2
DetailsSite: {"description":"Interaction with PxVP motif in substrate","evidences":[{"source":"PubMed","id":"23468591","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27974827","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI30
Number of Residues2
DetailsModified residue: {"description":"3'-nitrotyrosine","evidences":[{"source":"UniProtKB","id":"P63328","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
Catalytic Information from CSA
site_idMCSA1
Number of Residues10
DetailsM-CSA 406
ChainResidueDetails
HGLU89metal ligand
HLYS91metal ligand
HLYS117metal ligand
HVAL120electrostatic stabiliser
HGLY121transition state stabiliser
HSER149metal ligand
HPHE150proton shuttle (general acid/base)
site_idMCSA2
Number of Residues10
DetailsM-CSA 406
ChainResidueDetails
JGLU89metal ligand
JLYS91metal ligand
JLYS117metal ligand
JVAL120electrostatic stabiliser
JGLY121transition state stabiliser
JSER149metal ligand
JPHE150proton shuttle (general acid/base)

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PDB entries from 2026-01-21

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