9B4T
Crystal structure of the MRAS-p110alpha complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | polymer | 965 | 112033.4 | 1 | UniProt (P42336) Pfam (PF00794) Pfam (PF00792) Pfam (PF00613) Pfam (PF00454) | Homo sapiens (human) | PI3-kinase subunit alpha,PI3K-alpha,PI3Kalpha,PtdIns-3-kinase subunit alpha,Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha,PtdIns-3-kinase subunit p110-alpha,p110alpha,Phosphoinositide 3-kinase alpha,Phosphoinositide-3-kinase catalytic alpha polypeptide,Serine/threonine protein kinase PIK3CA |
| 2 | B (B) | Ras-related protein M-Ras | polymer | 179 | 20384.3 | 1 | UniProt (O14807) Pfam (PF00071) | Homo sapiens (human) | Ras-related protein R-Ras3 |
| 3 | C (A) | (2S)-2-({2-[1-(propan-2-yl)-1H-1,2,4-triazol-5-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl}oxy)propanamide | non-polymer | 382.4 | 1 | Chemie (5H5) | |||
| 4 | D (B) | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | non-polymer | 522.2 | 1 | Chemie (GNP) | |||
| 5 | E (B) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 6 | F, G (A, B) | water | water | 18.0 | 27 | Chemie (HOH) |
Sequence modifications
A: 105 - 1068 (UniProt: P42336)
B: 1 - 178 (UniProt: O14807)
| PDB | External Database | Details |
|---|---|---|
| Gly 104 | - | expression tag |
| Ala 1057 | Trp 1057 | engineered mutation |
| Ala 1058 | Ile 1058 | engineered mutation |
| Ala 1059 | Phe 1059 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Ala 35 | Gln 35 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 132417.7 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 928.9 | |
| All* | Total formula weight | 133346.6 |
