9B0B

Structure of Optineurin bound to HOIP NZF1 domain

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Optineurin	polymer	96	11043.5	4	UniProt (Q96CV9) In PDB	Homo sapiens (human)	E3-14.7K-interacting protein,FIP-2,Huntingtin yeast partner L,Huntingtin-interacting protein 7,HIP-7,Huntingtin-interacting protein L,NEMO-related protein,Optic neuropathy-inducing protein,Transcription factor IIIA-interacting protein,TFIIIA-IntP
2	G, E	E3 ubiquitin-protein ligase RNF31	polymer	30	3316.8	2	UniProt (Q96EP0) In PDB	Homo sapiens (human)	HOIL-1-interacting protein,HOIP,RING finger protein 31,RING-type E3 ubiquitin transferase RNF31,Zinc in-between-RING-finger ubiquitin-associated domain protein
3	A, B, G, C, D...	TRIETHYLENE GLYCOL	non-polymer		150.2	10	Chemie (PGE)
4	B, C	TETRAETHYLENE GLYCOL	non-polymer		194.2	2	Chemie (PG4)
5	G, E	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
6		water	water		18.0	283	Chemie (HOH)

Sequence modifications

A, B, C, D: 419 - 512 (UniProt: Q96CV9)

PDB	External Database	Details
Gly 417	-	expression tag
Pro 418	-	expression tag
Ser 472	Cys 472	engineered mutation
Glu 473	Ser 473	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	50807.5
Non-Polymers*	Number of molecules	14
	Total formula weight	2021.0
All*	Total formula weight	52828.5

*Water molecules are not included.