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9AYL

Cryo-EM structure of human Cav3.2 with ACT-709478

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
Voltage-dependent T-type calcium channel subunit alpha-1Hpolymer2116234853.61UniProt (O95180)
Pfam (PF00520)
Pfam (PF08016)
Homo sapiens (human)Low-voltage-activated calcium channel alpha1 3.2 subunit,Voltage-gated calcium channel subunit alpha Cav3.2
2B
(A)
N-{1-[(5-cyanopyridin-2-yl)methyl]-1H-pyrazol-3-yl}-2-{4-[1-(trifluoromethyl)cyclopropyl]phenyl}acetamidenon-polymer425.41Chemie (A1AHK)
3C, D
(A)
2-acetamido-2-deoxy-beta-D-glucopyranosenon-polymer221.22Chemie (NAG)
4E
(A)
CALCIUM IONnon-polymer40.11Chemie (CA)
5F
(A)
1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINEnon-polymer510.71Chemie (LPE)
6G, I, M, N
(A)
CHOLESTEROL HEMISUCCINATEnon-polymer486.74Chemie (Y01)
7H, J, K, L
(A)
[(2~{R})-3-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-2-pentadecanoyloxy-propyl] pentadecanoatenon-polymer663.94Chemie (JL3)
Sequence modifications
A: 1 - 771 (UniProt: O95180)
PDBExternal DatabaseDetails
Met -42-expression tag
Ala -41-expression tag
Ser -40-expression tag
Trp -39-expression tag
Ser -38-expression tag
His -37-expression tag
Pro -36-expression tag
Gln -35-expression tag
Phe -34-expression tag
Glu -33-expression tag
Lys -32-expression tag
Gly -31-expression tag
Gly -30-expression tag
Gly -29-expression tag
Ala -28-expression tag
Arg -27-expression tag
Gly -26-expression tag
Gly -25-expression tag
Ser -24-expression tag
Gly -23-expression tag
Gly -22-expression tag
Gly -21-expression tag
Ser -20-expression tag
Trp -19-expression tag
Ser -18-expression tag
His -17-expression tag
Pro -16-expression tag
Gln -15-expression tag
Phe -14-expression tag
Glu -13-expression tag
Lys -12-expression tag
Gly -11-expression tag
Phe -10-expression tag
Asp -9-expression tag
Tyr -8-expression tag
Lys -7-expression tag
Asp -6-expression tag
Asp -5-expression tag
Asp -4-expression tag
Asp -3-expression tag
Lys -2-expression tag
Gly -1-expression tag
Thr 0-expression tag
A: 772 - 2353 (UniProt: O95180)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight234853.6
Non-Polymers*Number of molecules13
Total formula weight6021.1
All*Total formula weight240874.7
*Water molecules are not included.

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PDB entries from 2024-11-06

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