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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

9AYL

Cryo-EM structure of human Cav3.2 with ACT-709478

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0005245	molecular_function	voltage-gated calcium channel activity
A	0005891	cellular_component	voltage-gated calcium channel complex
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0055085	biological_process	transmembrane transport
A	0070588	biological_process	calcium ion transmembrane transport

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1374
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
A	MET1-PRO100
A	GLU1556-SER1616
A	ARG1674-ARG1680
A	LEU1738-ASN1751
A	GLU1864-VAL2353
A	PHE161-ASP169
A	VAL213-ASN232
A	THR420-SER1073
A	LEU850-ASN855
A	VAL907-THR917
A	GLU1016-VAL1290
A	LEU1353-SER1362
A	VAL1419-ARG1428

site_id	SWS_FT_FI2
Number of Residues	18
Details	TRANSMEM: Helical; Name=S1 of repeat I => ECO:0000255

Chain	Residue	Details
A	TRP101-MET119

site_id	SWS_FT_FI3
Number of Residues	433
Details	TOPO_DOM: Extracellular => ECO:0000255

Chain	Residue	Details
A	PHE120-ALA141
A	HIS1638-TYR1651
A	GLU1700-ILE1713
A	ARG1773-LEU1835
A	GLU185-VAL193
A	GLY254-TYR394
A	HIS815-ILE827
A	GLN875-VAL882
A	CYS939-TRP990
A	GLU1314-SER1331
A	MET1383-ARG1396
A	LYS1453-PRO1529

site_id	SWS_FT_FI4
Number of Residues	18
Details	TRANSMEM: Helical; Name=S2 of repeat I => ECO:0000255

Chain	Residue	Details
A	PHE142-LEU160

site_id	SWS_FT_FI5
Number of Residues	14
Details	TRANSMEM: Helical; Name=S3 of repeat I => ECO:0000255

Chain	Residue	Details
A	THR170-MET184

site_id	SWS_FT_FI6
Number of Residues	18
Details	TRANSMEM: Helical; Name=S4 of repeat I => ECO:0000255

Chain	Residue	Details
A	SER194-ARG212

site_id	SWS_FT_FI7
Number of Residues	20
Details	TRANSMEM: Helical; Name=S5 of repeat I => ECO:0000255

Chain	Residue	Details
A	VAL233-ALA253

site_id	SWS_FT_FI8
Number of Residues	24
Details	TRANSMEM: Helical; Name=S6 of repeat I => ECO:0000255

Chain	Residue	Details
A	ASN395-ALA419

site_id	SWS_FT_FI9
Number of Residues	20
Details	TRANSMEM: Helical; Name=S1 of repeat II => ECO:0000255

Chain	Residue	Details
A	TYR794-TYR814

site_id	SWS_FT_FI10
Number of Residues	21
Details	TRANSMEM: Helical; Name=S2 of repeat II => ECO:0000255

Chain	Residue	Details
A	SER828-PRO849

site_id	SWS_FT_FI11
Number of Residues	18
Details	TRANSMEM: Helical; Name=S3 of repeat II => ECO:0000255

Chain	Residue	Details
A	PRO856-GLY874

site_id	SWS_FT_FI12
Number of Residues	23
Details	TRANSMEM: Helical; Name=S4 of repeat II => ECO:0000255

Chain	Residue	Details
A	LEU883-VAL906

site_id	SWS_FT_FI13
Number of Residues	20
Details	TRANSMEM: Helical; Name=S5 of repeat II => ECO:0000255

Chain	Residue	Details
A	PHE918-GLY938

site_id	SWS_FT_FI14
Number of Residues	24
Details	TRANSMEM: Helical; Name=S6 of repeat II => ECO:0000255

Chain	Residue	Details
A	ALA991-VAL1015

site_id	SWS_FT_FI15
Number of Residues	22
Details	TRANSMEM: Helical; Name=S1 of repeat III => ECO:0000255

Chain	Residue	Details
A	ILE1291-LEU1313

site_id	SWS_FT_FI16
Number of Residues	20
Details	TRANSMEM: Helical; Name=S2 of repeat III => ECO:0000255

Chain	Residue	Details
A	ASN1332-LEU1352

site_id	SWS_FT_FI17
Number of Residues	19
Details	TRANSMEM: Helical; Name=S3 of repeat III => ECO:0000255

Chain	Residue	Details
A	SER1363-ALA1382

site_id	SWS_FT_FI18
Number of Residues	21
Details	TRANSMEM: Helical; Name=S4 of repeat III => ECO:0000255

Chain	Residue	Details
A	VAL1397-LEU1418

site_id	SWS_FT_FI19
Number of Residues	23
Details	TRANSMEM: Helical; Name=S5 of repeat III => ECO:0000255

Chain	Residue	Details
A	PRO1429-PHE1452

site_id	SWS_FT_FI20
Number of Residues	25
Details	TRANSMEM: Helical; Name=S6 of repeat III => ECO:0000255

Chain	Residue	Details
A	TRP1530-VAL1555

site_id	SWS_FT_FI21
Number of Residues	20
Details	TRANSMEM: Helical; Name=S1 of repeat IV => ECO:0000255

Chain	Residue	Details
A	HIS1617-GLU1637

site_id	SWS_FT_FI22
Number of Residues	21
Details	TRANSMEM: Helical; Name=S2 of repeat IV => ECO:0000255

Chain	Residue	Details
A	CYS1652-PHE1673

site_id	SWS_FT_FI23
Number of Residues	18
Details	TRANSMEM: Helical; Name=S3 of repeat IV => ECO:0000255

Chain	Residue	Details
A	TRP1681-GLU1699

site_id	SWS_FT_FI24
Number of Residues	23
Details	TRANSMEM: Helical; Name=S4 of repeat IV => ECO:0000255

Chain	Residue	Details
A	ILE1714-ALA1737

site_id	SWS_FT_FI25
Number of Residues	20
Details	TRANSMEM: Helical; Name=S5 of repeat IV => ECO:0000255

Chain	Residue	Details
A	LEU1752-GLY1772

site_id	SWS_FT_FI26
Number of Residues	27
Details	TRANSMEM: Helical; Name=S6 of repeat IV => ECO:0000255

Chain	Residue	Details
A	SER1836-LEU1863

site_id	SWS_FT_FI27
Number of Residues	3
Details	BINDING:

Chain	Residue	Details
A	ASP140
A	ASP189
A	HIS191

site_id	SWS_FT_FI28
Number of Residues	4
Details	SITE: Calcium ion selectivity and permeability => ECO:0000250

Chain	Residue	Details
A	GLU378
A	GLU974
A	ASP1504
A	ASP1808

site_id	SWS_FT_FI29
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN192
A	ASN271
A	ASN1466

227111

PDB entries from 2024-11-06

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