9AYK

Cryo-EM structure of human Cav3.2 with ML218

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Voltage-dependent T-type calcium channel subunit alpha-1H	polymer	2116	234853.6	1	UniProt (O95180) Pfam (PF00520) In PDB	Homo sapiens (human)	Low-voltage-activated calcium channel alpha1 3.2 subunit,Voltage-gated calcium channel subunit alpha Cav3.2
2	A	3,5-dichloro-N-{[(1R,5S,6r)-3-(3,3-dimethylbutyl)-3-azabicyclo[3.1.0]hexan-6-yl]methyl}benzamide	non-polymer		369.3	1	Chemie (A1AHJ)
3	A	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
4	A	CALCIUM ION	non-polymer		40.1	1	Chemie (CA)
5	A	1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE	non-polymer		510.7	1	Chemie (LPE)
6	A	CHOLESTEROL HEMISUCCINATE	non-polymer		486.7	4	Chemie (Y01)
7	A	[(2~{R})-3-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-2-pentadecanoyloxy-propyl] pentadecanoate	non-polymer		663.9	4	Chemie (JL3)

Sequence modifications

A: 1 - 771 (UniProt: O95180)

PDB	External Database	Details
Met -42	-	expression tag
Ala -41	-	expression tag
Ser -40	-	expression tag
Trp -39	-	expression tag
Ser -38	-	expression tag
His -37	-	expression tag
Pro -36	-	expression tag
Gln -35	-	expression tag
Phe -34	-	expression tag
Glu -33	-	expression tag
Lys -32	-	expression tag
Gly -31	-	expression tag
Gly -30	-	expression tag
Gly -29	-	expression tag
Ala -28	-	expression tag
Arg -27	-	expression tag
Gly -26	-	expression tag
Gly -25	-	expression tag
Ser -24	-	expression tag
Gly -23	-	expression tag
Gly -22	-	expression tag
Gly -21	-	expression tag
Ser -20	-	expression tag
Trp -19	-	expression tag
Ser -18	-	expression tag
His -17	-	expression tag
Pro -16	-	expression tag
Gln -15	-	expression tag
Phe -14	-	expression tag
Glu -13	-	expression tag
Lys -12	-	expression tag
Gly -11	-	expression tag
Phe -10	-	expression tag
Asp -9	-	expression tag
Tyr -8	-	expression tag
Lys -7	-	expression tag
Asp -6	-	expression tag
Asp -5	-	expression tag
Asp -4	-	expression tag
Asp -3	-	expression tag
Lys -2	-	expression tag
Gly -1	-	expression tag
Thr 0	-	expression tag

A: 772 - 2353 (UniProt: O95180)

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	234853.6
Non-Polymers*	Number of molecules	13
	Total formula weight	5965.1
All*	Total formula weight	240818.7

*Water molecules are not included.