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9AXM

Crystal structure of ARAF/MEK1 complex with NST-628 and a RAF dimer

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, C
(A, C)
Dual specificity mitogen-activated protein kinase kinase 1polymer31034543.82UniProt (Q02750)
Pfam (PF00069)
Homo sapiens (human)MAP kinase kinase 1,MAPKK 1,MKK1,ERK activator kinase 1,MAPK/ERK kinase 1,MEK 1
2B, D
(B, D)
Serine/threonine-protein kinase A-Rafpolymer28031722.62UniProt (P10398)
Pfam (PF07714)
Homo sapiens (human)Proto-oncogene A-Raf,Proto-oncogene A-Raf-1,Proto-oncogene Pks
3E, K
(A, C)
N-[3-fluoro-4-({7-[(3-fluoropyridin-2-yl)oxy]-4-methyl-2-oxo-2H-1-benzopyran-3-yl}methyl)pyridin-2-yl]-N'-methylsulfuric diamidenon-polymer488.52Chemie (A1AHE)
4F, H
(A, B)
MAGNESIUM IONnon-polymer24.32Chemie (MG)
5G, I
(A, B)
PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTERnon-polymer506.22Chemie (ANP)
6J
(B)
1,2-ETHANEDIOLnon-polymer62.11Chemie (EDO)
7L, M, N
(C, D)
GLYCEROLnon-polymer92.13Chemie (GOL)
8O, P, Q, R
(A, B, C, D)
waterwater18.0117Chemie (HOH)
Sequence modifications
A, C: 37 - 263 (UniProt: Q02750)
PDBExternal DatabaseDetails
Gly 36-expression tag
Ala 218Ser 218engineered mutation
Ala 222Ser 222engineered mutation
A, C: 308 - 383 (UniProt: Q02750)
PDBExternal DatabaseDetails
Gly 264-linker
Ser 265-linker
Gly 266-linker
Ser 305-linker
Gly 306-linker
Ser 307-linker
B, D: 298 - 576 (UniProt: P10398)
PDBExternal DatabaseDetails
Gly 297-expression tag
Asp 301Tyr 301engineered mutation
Asp 302Tyr 302engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight132532.8
Non-Polymers*Number of molecules10
Total formula weight2376.3
All*Total formula weight134909.1
*Water molecules are not included.

238268

PDB entries from 2025-07-02

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