9AXM
Crystal structure of ARAF/MEK1 complex with NST-628 and a RAF dimer
This is a non-PDB format compatible entry.
Functional Information from PROSITE/UniProt
site_id | PS00107 |
Number of Residues | 21 |
Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGTGSFGTVFrGrwhgd.............VAVK |
Chain | Residue | Details |
B | ILE316-LYS336 | |
A | LEU74-LYS97 |
site_id | PS00108 |
Number of Residues | 13 |
Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHrDLKsnNIFL |
Chain | Residue | Details |
B | ILE425-LEU437 | |
A | ILE186-VAL198 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 |
Chain | Residue | Details |
B | ASP429 | |
D | ASP429 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 |
Chain | Residue | Details |
B | ILE316 | |
B | LYS336 | |
D | ILE316 | |
D | LYS336 | |
A | ASP208 | |
C | LEU74 | |
C | MET143 | |
C | SER150 | |
C | LYS192 | |
C | ASP208 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:19690332 |
Chain | Residue | Details |
B | THR318 | |
D | THR318 |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:19161339, ECO:0007744|PDB:3EQF |
Chain | Residue | Details |
A | GLU144 | |
A | SER194 | |
C | GLU144 | |
C | SER194 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine; by BRAF and RAF1 => ECO:0000269|PubMed:10409742, ECO:0000269|PubMed:20956560, ECO:0000269|PubMed:29433126, ECO:0000269|PubMed:8131746 |
Chain | Residue | Details |
A | ALA218 | |
C | ALA218 |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine; by BRAF and RAF1 => ECO:0000269|PubMed:20956560, ECO:0000269|PubMed:29433126, ECO:0000269|PubMed:8131746 |
Chain | Residue | Details |
A | ALA222 | |
C | ALA222 |