8ZMG
Crystal structure of an inverse agonist antipsychotic drug pimavanserin-bound 5-HT2A
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | 5-hydroxytryptamine receptor 2A,Soluble cytochrome b562 | polymer | 414 | 46606.3 | 2 | UniProt (P28223) UniProt (P0ABE7) Pfam (PF00001) Pfam (PF07361) | Homo sapiens (human) | 5-HT-2,5-HT-2A,Serotonin receptor 2A,Cytochrome b-562 |
| 2 | C, D (A, B) | Pimavanserin | non-polymer | 427.6 | 2 | Chemie (A1L11) |
Sequence modifications
A, B: 70 - 265 (UniProt: P28223)
A, B: 1001 - 1040 (UniProt: P0ABE7)
A, B: 1046 - 1086 (UniProt: P0ABE7)
A, B: 313 - 403 (UniProt: P28223)
| PDB | External Database | Details |
|---|---|---|
| Met 37 | - | initiating methionine |
| Lys 38 | - | expression tag |
| Thr 39 | - | expression tag |
| Ile 40 | - | expression tag |
| Ile 41 | - | expression tag |
| Ala 42 | - | expression tag |
| Leu 43 | - | expression tag |
| Ser 44 | - | expression tag |
| Tyr 45 | - | expression tag |
| Ile 46 | - | expression tag |
| Phe 47 | - | expression tag |
| Cys 48 | - | expression tag |
| Leu 49 | - | expression tag |
| Val 50 | - | expression tag |
| Phe 51 | - | expression tag |
| Ala 52 | - | expression tag |
| Asp 53 | - | expression tag |
| Tyr 54 | - | expression tag |
| Lys 55 | - | expression tag |
| Asp 56 | - | expression tag |
| Asp 57 | - | expression tag |
| Asp 58 | - | expression tag |
| Asp 59 | - | expression tag |
| Lys 60 | - | expression tag |
| Glu 61 | - | expression tag |
| Asn 62 | - | expression tag |
| Leu 63 | - | expression tag |
| Tyr 64 | - | expression tag |
| Phe 65 | - | expression tag |
| Gln 66 | - | expression tag |
| Gly 67 | - | expression tag |
| Thr 68 | - | expression tag |
| Ser 69 | - | expression tag |
| Lys 162 | Ser 162 | engineered mutation |
| Trp 164 | Met 164 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Trp 1007 | Met 29 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 1041 | - | linker |
| Ser 1042 | - | linker |
| Gly 1043 | - | linker |
| Ser 1044 | - | linker |
| Gly 1045 | - | linker |
| Ile 1078 | Arg 120 | engineered mutation |
| Ile 1082 | His 124 | engineered mutation |
| Gly 1086 | Arg 128 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Leu 404 | - | expression tag |
| Glu 405 | - | expression tag |
| Glu 406 | - | expression tag |
| Asn 407 | - | expression tag |
| Leu 408 | - | expression tag |
| Tyr 409 | - | expression tag |
| Phe 410 | - | expression tag |
| Gln 411 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 93212.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 855.1 | |
| All* | Total formula weight | 94067.7 |
