8ZMG
Crystal structure of an inverse agonist antipsychotic drug pimavanserin-bound 5-HT2A
This is a non-PDB format compatible entry.
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 46 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000250 |
| Chain | Residue | Details |
| A | TRP76-VAL99 | |
| B | TRP76-VAL99 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 58 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000250 |
| Chain | Residue | Details |
| A | SER100-ASN110 | |
| A | ASP172-LYS191 | |
| B | SER100-ASN110 | |
| B | ASP172-LYS191 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 42 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000250 |
| Chain | Residue | Details |
| A | TYR111-MET132 | |
| B | TYR111-MET132 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 94 |
| Details | TOPO_DOM: Extracellular => ECO:0000250 |
| Chain | Residue | Details |
| A | LEU133-CYS148 | |
| A | GLN216-ASN233 | |
| A | VAL347-LEU362 | |
| B | LEU133-CYS148 | |
| B | GLN216-ASN233 | |
| B | VAL347-LEU362 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 44 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000250 |
| Chain | Residue | Details |
| A | ALA149-LEU171 | |
| B | ALA149-LEU171 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 46 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000250 |
| Chain | Residue | Details |
| A | ALA192-LEU215 | |
| B | ALA192-LEU215 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000250 |
| Chain | Residue | Details |
| A | PHE234-TYR254 | |
| B | PHE234-TYR254 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 42 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000250 |
| Chain | Residue | Details |
| A | LEU325-ALA346 | |
| B | LEU325-ALA346 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 42 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000250 |
| Chain | Residue | Details |
| A | ASN363-ASN384 | |
| B | ASN363-ASN384 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P41595 |
| Chain | Residue | Details |
| A | ASP155 | |
| A | THR160 | |
| A | LEU229 | |
| B | ASP155 | |
| B | THR160 | |
| B | LEU229 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | SITE: Hydrophobic barrier that decreases the speed of ligand binding and dissociation => ECO:0000269|PubMed:28129538 |
| Chain | Residue | Details |
| A | LEU229 | |
| B | LEU229 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 4 |
| Details | BINDING: axial binding residue |
| Chain | Residue | Details |
| A | TRP1007 | |
| A | ILE1082 | |
| B | TRP1007 | |
| B | ILE1082 |
