8ZJF
Cryo-EM structure of human integrin alpha-E beta-7
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | Integrin beta-7 | polymer | 826 | 90055.4 | 1 | UniProt (P26010) Pfam (PF17205) Pfam (PF00362) Pfam (PF07974) Pfam (PF08725) | Homo sapiens (human) | Gut homing receptor beta subunit |
| 2 | B (A) | Integrin alpha-E | polymer | 1198 | 132436.5 | 1 | UniProt (P38570) Pfam (PF00092) Pfam (PF01839) Pfam (PF20805) Pfam (PF00357) | Homo sapiens (human) | HML-1 antigen,Integrin alpha-IEL,Mucosal lymphocyte 1 antigen |
| 3 | C (C) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 4 | D (B) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 5 | E, F (B) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) |
Sequence modifications
B: 2 - 798 (UniProt: P26010)
A: 2 - 1179 (UniProt: P38570)
| PDB | External Database | Details |
|---|---|---|
| Gly 799 | - | expression tag |
| Ser 800 | - | expression tag |
| Gly 801 | - | expression tag |
| Ser 802 | - | expression tag |
| Gly 803 | - | expression tag |
| Leu 804 | - | expression tag |
| Asn 805 | - | expression tag |
| Asp 806 | - | expression tag |
| Ile 807 | - | expression tag |
| Phe 808 | - | expression tag |
| Glu 809 | - | expression tag |
| Ala 810 | - | expression tag |
| Gln 811 | - | expression tag |
| Lys 812 | - | expression tag |
| Ile 813 | - | expression tag |
| Glu 814 | - | expression tag |
| Trp 815 | - | expression tag |
| His 816 | - | expression tag |
| Glu 817 | - | expression tag |
| Gly 818 | - | expression tag |
| Ser 819 | - | expression tag |
| Gly 820 | - | expression tag |
| Ser 821 | - | expression tag |
| Glu 822 | - | expression tag |
| Asn 823 | - | expression tag |
| Leu 824 | - | expression tag |
| Tyr 825 | - | expression tag |
| Phe 826 | - | expression tag |
| Gln 827 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Leu 1180 | - | expression tag |
| Glu 1181 | - | expression tag |
| Leu 1182 | - | expression tag |
| Glu 1183 | - | expression tag |
| Val 1184 | - | expression tag |
| Leu 1185 | - | expression tag |
| Phe 1186 | - | expression tag |
| Gln 1187 | - | expression tag |
| Gly 1188 | - | expression tag |
| Pro 1189 | - | expression tag |
| Gly 1190 | - | expression tag |
| Ser 1191 | - | expression tag |
| Asp 1192 | - | expression tag |
| Tyr 1193 | - | expression tag |
| Lys 1194 | - | expression tag |
| Asp 1195 | - | expression tag |
| Asp 1196 | - | expression tag |
| Asp 1197 | - | expression tag |
| Asp 1198 | - | expression tag |
| Lys 1199 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 222491.9 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 586.5 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 104.5 | |
| All* | Total formula weight | 223182.9 |
