Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8ZJF

Cryo-EM structure of human integrin alpha-E beta-7

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0007155	biological_process	cell adhesion
A	0008305	cellular_component	integrin complex

Functional Information from PROSITE/UniProt

site_id	PS00022
Number of Residues	12
Details	EGF_1 EGF-like domain signature 1. CsCapGrlGRlC

Chain	Residue	Details
B	CYS500-CYS511
B	CYS548-CYS559
B	CYS585-CYS596
B	CYS624-CYS635

site_id	PS00198
Number of Residues	12
Details	4FE4S_FER_1 4Fe-4S ferredoxin-type iron-sulfur binding region signature. CdQCPgCKtPCE

Chain	Residue	Details
B	CYS635-GLU646

site_id	PS00242
Number of Residues	8
Details	INTEGRIN_ALPHA Integrins alpha chain signature. FKcGFFkR

Chain	Residue	Details
A	PHE1147-ARG1154

site_id	PS00243
Number of Residues	14
Details	I_EGF_1 Integrins beta chain EGF (I-EGF) domain signature. CsGk..GhCqCgrCsC

Chain	Residue	Details
B	CYS537-CYS550
B	CYS574-CYS587
B	CYS613-CYS626

site_id	PS01186
Number of Residues	15
Details	EGF_2 EGF-like domain signature 2. CqCldGYygalcdq.C

Chain	Residue	Details
B	CYS624-CYS638

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	48
Details	Domain: {"description":"PSI","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	239
Details	Domain: {"description":"VWFA","evidences":[{"source":"PubMed","id":"10837471","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	34
Details	Domain: {"description":"I-EGF 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01392","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	26
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"description":"in MIDAS binding site","evidences":[{"source":"PubMed","id":"22232704","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38781659","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3V4V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ZJF","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	1
Details	Binding site: {"description":"in MIDAS binding site","evidences":[{"source":"PubMed","id":"22232704","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3V4V","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	1
Details	Binding site: {"description":"in ADMIDAS binding site","evidences":[{"source":"PubMed","id":"22232704","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38781659","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3V4V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ZJF","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	1
Details	Binding site: {"description":"in ADMIDAS binding site","evidences":[{"source":"PubMed","id":"22232704","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38781659","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3V4P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ZJF","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	4
Details	Binding site: {"description":"in LIMBS binding site","evidences":[{"source":"PubMed","id":"22232704","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38781659","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3V4P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3V4V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ZJF","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	1
Details	Binding site: {"description":"in MIDAS binding site","evidences":[{"source":"PubMed","id":"22232704","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38781659","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3V4P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3V4V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ZJF","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	1
Details	Binding site: {"description":"in ADMIDAS binding site and liganded-open conformation","evidences":[{"source":"UniProtKB","id":"P05107","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	1
Details	Binding site: {"description":"in ADMIDAS binding site and unliganded-closed conformation","evidences":[{"source":"PubMed","id":"22232704","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38781659","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3V4P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3V4V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ZJF","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	11
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"22232704","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3V4P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3V4V","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"22232704","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3V4V","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	189
Details	Domain: {"description":"VWFA","evidences":[{"source":"PROSITE-ProRule","id":"PRU00219","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	52
Details	Repeat: {"description":"FG-GAP 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00803","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	52
Details	Repeat: {"description":"FG-GAP 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00803","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	60
Details	Repeat: {"description":"FG-GAP 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00803","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	64
Details	Repeat: {"description":"FG-GAP 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00803","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	60
Details	Repeat: {"description":"FG-GAP 5","evidences":[{"source":"PROSITE-ProRule","id":"PRU00803","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P08648","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)