8ZJ2
Cryo-EM structure of the RhoG/DOCK5/ELMO1/Rac1 complex
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (B, F) | Dedicator of cytokinesis protein 5 | polymer | 1648 | 191492.1 | 2 | UniProt (Q9H7D0) Pfam (PF20421) Pfam (PF00018) Pfam (PF16172) Pfam (PF14429) Pfam (PF23554) Pfam (PF06920) Pfam (PF20422) | Homo sapiens (human) | |
| 2 | B, D (C, G) | Ras-related C3 botulinum toxin substrate 1 | polymer | 184 | 20244.3 | 2 | UniProt (P63000) Pfam (PF00071) | Homo sapiens (human) | Cell migration-inducing gene 5 protein,Ras-like protein TC25,p21-Rac1 |
| 3 | E, F (E, A) | Engulfment and cell motility protein 1 | polymer | 733 | 84337.7 | 2 | UniProt (Q92556) Pfam (PF11841) Pfam (PF04727) Pfam (PF16457) | Homo sapiens (human) | Protein ced-12 homolog |
| 4 | G (D) | Rho-related GTP-binding protein RhoG | polymer | 203 | 22362.4 | 1 | UniProt (P84095) Pfam (PF00071) | Homo sapiens (human) | |
| 5 | H (D) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) PubChem (888) | |||
| 6 | I (D) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 1 | Chemie (GTP) PubChem (177679032) PubChem (135400627) PubChem (135487750) PubChem (136088935) PubChem (136803486) PubChem (135398633) PubChem (135544356) PubChem (135547949) PubChem (135600366) PubChem (135749822) PubChem (136005188) PubChem (136073923) PubChem (136240914) PubChem (136664747) PubChem (136772743) PubChem (136772744) PubChem (136803487) PubChem (137286749) PubChem (164715984) PubChem (171699466) |
Sequence modifications
B, F: 1 - 1642 (UniProt: Q9H7D0)
C, G: 1 - 177 (UniProt: P63000)
E, A: 1 - 727 (UniProt: Q92556)
D: 1 - 184 (UniProt: P84095)
| PDB | External Database | Details |
|---|---|---|
| Gly -5 | - | expression tag |
| Gly -4 | - | expression tag |
| Ser -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Arg 1285 | Lys 1285 | variant |
| PDB | External Database | Details |
|---|---|---|
| Gly -6 | - | expression tag |
| Ser -5 | - | expression tag |
| Ser -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Ala 15 | Gly 15 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly -5 | - | expression tag |
| Gly -4 | - | expression tag |
| Ser -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly -6 | - | expression tag |
| Ser -5 | - | expression tag |
| Ser -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Leu 61 | Gln 61 | engineered mutation |
| Ser 185 | - | expression tag |
| Gly 186 | - | expression tag |
| Pro 187 | - | expression tag |
| Ser 188 | - | expression tag |
| Ser 189 | - | expression tag |
| Gly 190 | - | expression tag |
| Glu 191 | - | expression tag |
| Asn 192 | - | expression tag |
| Leu 193 | - | expression tag |
| Tyr 194 | - | expression tag |
| Phe 195 | - | expression tag |
| Gln 196 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 7 |
| Total formula weight | 614510.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 547.5 | |
| All* | Total formula weight | 615058.0 |
