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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8ZJ2

Cryo-EM structure of the RhoG/DOCK5/ELMO1/Rac1 complex

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
A0005085molecular_functionguanyl-nucleotide exchange factor activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006909biological_processphagocytosis
A0006911biological_processphagocytosis, engulfment
A0006915biological_processapoptotic process
A0007015biological_processactin filament organization
A0016020cellular_componentmembrane
A0016601biological_processRac protein signal transduction
A0017124molecular_functionSH3 domain binding
A0030029biological_processactin filament-based process
A0030036biological_processactin cytoskeleton organization
A0032045cellular_componentguanyl-nucleotide exchange factor complex
A0048870biological_processcell motility
A0098794cellular_componentpostsynapse
A0098978cellular_componentglutamatergic synapse
A0150052biological_processregulation of postsynapse assembly
B0005085molecular_functionguanyl-nucleotide exchange factor activity
B0005096molecular_functionGTPase activator activity
B0007264biological_processsmall GTPase-mediated signal transduction
B0016477biological_processcell migration
C0000166molecular_functionnucleotide binding
C0000242cellular_componentpericentriolar material
C0001764biological_processneuron migration
C0001891cellular_componentphagocytic cup
C0001934biological_processpositive regulation of protein phosphorylation
C0002093biological_processauditory receptor cell morphogenesis
C0003376biological_processsphingosine-1-phosphate receptor signaling pathway
C0003382biological_processepithelial cell morphogenesis
C0003924molecular_functionGTPase activity
C0003925molecular_functionG protein activity
C0005515molecular_functionprotein binding
C0005525molecular_functionGTP binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005789cellular_componentendoplasmic reticulum membrane
C0005802cellular_componenttrans-Golgi network
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005884cellular_componentactin filament
C0005886cellular_componentplasma membrane
C0005925cellular_componentfocal adhesion
C0005938cellular_componentcell cortex
C0006897biological_processendocytosis
C0006911biological_processphagocytosis, engulfment
C0006954biological_processinflammatory response
C0006972biological_processhyperosmotic response
C0007010biological_processcytoskeleton organization
C0007015biological_processactin filament organization
C0007155biological_processcell adhesion
C0007160biological_processcell-matrix adhesion
C0007163biological_processestablishment or maintenance of cell polarity
C0007167biological_processenzyme-linked receptor protein signaling pathway
C0007186biological_processG protein-coupled receptor signaling pathway
C0007264biological_processsmall GTPase-mediated signal transduction
C0007411biological_processaxon guidance
C0008045biological_processmotor neuron axon guidance
C0008360biological_processregulation of cell shape
C0009611biological_processresponse to wounding
C0009653biological_processanatomical structure morphogenesis
C0010310biological_processregulation of hydrogen peroxide metabolic process
C0010591biological_processregulation of lamellipodium assembly
C0010592biological_processpositive regulation of lamellipodium assembly
C0010595biological_processpositive regulation of endothelial cell migration
C0010762biological_processregulation of fibroblast migration
C0010764biological_processnegative regulation of fibroblast migration
C0010810biological_processregulation of cell-substrate adhesion
C0010811biological_processpositive regulation of cell-substrate adhesion
C0014041biological_processregulation of neuron maturation
C0016020cellular_componentmembrane
C0016358biological_processdendrite development
C0016477biological_processcell migration
C0016601biological_processRac protein signal transduction
C0016787molecular_functionhydrolase activity
C0019899molecular_functionenzyme binding
C0019901molecular_functionprotein kinase binding
C0021799biological_processcerebral cortex radially oriented cell migration
C0021831biological_processembryonic olfactory bulb interneuron precursor migration
C0021894biological_processcerebral cortex GABAergic interneuron development
C0022604biological_processregulation of cell morphogenesis
C0030027cellular_componentlamellipodium
C0030031biological_processcell projection assembly
C0030032biological_processlamellipodium assembly
C0030036biological_processactin cytoskeleton organization
C0030041biological_processactin filament polymerization
C0030334biological_processregulation of cell migration
C0030425cellular_componentdendrite
C0030667cellular_componentsecretory granule membrane
C0030672cellular_componentsynaptic vesicle membrane
C0030742molecular_functionGTP-dependent protein binding
C0030838biological_processpositive regulation of actin filament polymerization
C0030865biological_processcortical cytoskeleton organization
C0030900biological_processforebrain development
C0031116biological_processpositive regulation of microtubule polymerization
C0031410cellular_componentcytoplasmic vesicle
C0031529biological_processruffle organization
C0031901cellular_componentearly endosome membrane
C0031996molecular_functionthioesterase binding
C0032496biological_processresponse to lipopolysaccharide
C0032587cellular_componentruffle membrane
C0032707biological_processnegative regulation of interleukin-23 production
C0032956biological_processregulation of actin cytoskeleton organization
C0034446biological_processsubstrate adhesion-dependent cell spreading
C0035025biological_processpositive regulation of Rho protein signal transduction
C0035556biological_processintracellular signal transduction
C0035567biological_processnon-canonical Wnt signaling pathway
C0035774biological_processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
C0036464cellular_componentcytoplasmic ribonucleoprotein granule
C0042470cellular_componentmelanosome
C0042554biological_processsuperoxide anion generation
C0042734cellular_componentpresynaptic membrane
C0042995cellular_componentcell projection
C0043020cellular_componentNADPH oxidase complex
C0043131biological_processerythrocyte enucleation
C0043652biological_processengulfment of apoptotic cell
C0044877molecular_functionprotein-containing complex binding
C0045202cellular_componentsynapse
C0045211cellular_componentpostsynaptic membrane
C0045216biological_processcell-cell junction organization
C0045428biological_processregulation of nitric oxide biosynthetic process
C0045730biological_processrespiratory burst
C0046425biological_processregulation of receptor signaling pathway via JAK-STAT
C0048012biological_processhepatocyte growth factor receptor signaling pathway
C0048168biological_processregulation of neuronal synaptic plasticity
C0048261biological_processnegative regulation of receptor-mediated endocytosis
C0048532biological_processanatomical structure arrangement
C0048812biological_processneuron projection morphogenesis
C0048813biological_processdendrite morphogenesis
C0048870biological_processcell motility
C0048873biological_processhomeostasis of number of cells within a tissue
C0051022molecular_functionRho GDP-dissociation inhibitor binding
C0051492biological_processregulation of stress fiber assembly
C0051496biological_processpositive regulation of stress fiber assembly
C0051668biological_processlocalization within membrane
C0051894biological_processpositive regulation of focal adhesion assembly
C0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
C0051932biological_processsynaptic transmission, GABAergic
C0055038cellular_componentrecycling endosome membrane
C0060071biological_processWnt signaling pathway, planar cell polarity pathway
C0060091cellular_componentkinocilium
C0060263biological_processregulation of respiratory burst
C0060326biological_processcell chemotaxis
C0060999biological_processpositive regulation of dendritic spine development
C0061344biological_processregulation of cell adhesion involved in heart morphogenesis
C0070062cellular_componentextracellular exosome
C0070376biological_processregulation of ERK5 cascade
C0071526biological_processsemaphorin-plexin signaling pathway
C0071542biological_processdopaminergic neuron differentiation
C0072659biological_processprotein localization to plasma membrane
C0086098biological_processangiotensin-activated signaling pathway involved in heart process
C0090023biological_processpositive regulation of neutrophil chemotaxis
C0090103biological_processcochlea morphogenesis
C0097178biological_processruffle assembly
C0098794cellular_componentpostsynapse
C0098978cellular_componentglutamatergic synapse
C0101003cellular_componentficolin-1-rich granule membrane
C0150052biological_processregulation of postsynapse assembly
C1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
C1900029biological_processpositive regulation of ruffle assembly
C1900242biological_processregulation of synaptic vesicle endocytosis
C1902622biological_processregulation of neutrophil migration
C1903348biological_processpositive regulation of bicellular tight junction assembly
C1904395biological_processpositive regulation of skeletal muscle acetylcholine-gated channel clustering
C1904936biological_processinterneuron migration
C1904948biological_processmidbrain dopaminergic neuron differentiation
C2000386biological_processpositive regulation of ovarian follicle development
C2001222biological_processregulation of neuron migration
D0000166molecular_functionnucleotide binding
D0003924molecular_functionGTPase activity
D0005515molecular_functionprotein binding
D0005525molecular_functionGTP binding
D0005789cellular_componentendoplasmic reticulum membrane
D0005829cellular_componentcytosol
D0005856cellular_componentcytoskeleton
D0005886cellular_componentplasma membrane
D0005925cellular_componentfocal adhesion
D0007015biological_processactin filament organization
D0007163biological_processestablishment or maintenance of cell polarity
D0007264biological_processsmall GTPase-mediated signal transduction
D0007266biological_processRho protein signal transduction
D0008284biological_processpositive regulation of cell population proliferation
D0008360biological_processregulation of cell shape
D0016020cellular_componentmembrane
D0016601biological_processRac protein signal transduction
D0019901molecular_functionprotein kinase binding
D0030036biological_processactin cytoskeleton organization
D0030667cellular_componentsecretory granule membrane
D0030865biological_processcortical cytoskeleton organization
D0031410cellular_componentcytoplasmic vesicle
D0032956biological_processregulation of actin cytoskeleton organization
D0042995cellular_componentcell projection
D0045893biological_processpositive regulation of DNA-templated transcription
D0060326biological_processcell chemotaxis
D0070062cellular_componentextracellular exosome
D0090630biological_processactivation of GTPase activity
D0098794cellular_componentpostsynapse
D0098978cellular_componentglutamatergic synapse
D0150052biological_processregulation of postsynapse assembly
D1900027biological_processregulation of ruffle assembly
D1903078biological_processpositive regulation of protein localization to plasma membrane
E0005085molecular_functionguanyl-nucleotide exchange factor activity
E0005515molecular_functionprotein binding
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0005886cellular_componentplasma membrane
E0006909biological_processphagocytosis
E0006911biological_processphagocytosis, engulfment
E0006915biological_processapoptotic process
E0007015biological_processactin filament organization
E0016020cellular_componentmembrane
E0016601biological_processRac protein signal transduction
E0017124molecular_functionSH3 domain binding
E0030029biological_processactin filament-based process
E0030036biological_processactin cytoskeleton organization
E0032045cellular_componentguanyl-nucleotide exchange factor complex
E0048870biological_processcell motility
E0098794cellular_componentpostsynapse
E0098978cellular_componentglutamatergic synapse
E0150052biological_processregulation of postsynapse assembly
F0005085molecular_functionguanyl-nucleotide exchange factor activity
F0005096molecular_functionGTPase activator activity
F0007264biological_processsmall GTPase-mediated signal transduction
F0016477biological_processcell migration
G0000166molecular_functionnucleotide binding
G0000242cellular_componentpericentriolar material
G0001764biological_processneuron migration
G0001891cellular_componentphagocytic cup
G0001934biological_processpositive regulation of protein phosphorylation
G0002093biological_processauditory receptor cell morphogenesis
G0003376biological_processsphingosine-1-phosphate receptor signaling pathway
G0003382biological_processepithelial cell morphogenesis
G0003924molecular_functionGTPase activity
G0003925molecular_functionG protein activity
G0005515molecular_functionprotein binding
G0005525molecular_functionGTP binding
G0005634cellular_componentnucleus
G0005737cellular_componentcytoplasm
G0005789cellular_componentendoplasmic reticulum membrane
G0005802cellular_componenttrans-Golgi network
G0005829cellular_componentcytosol
G0005856cellular_componentcytoskeleton
G0005884cellular_componentactin filament
G0005886cellular_componentplasma membrane
G0005925cellular_componentfocal adhesion
G0005938cellular_componentcell cortex
G0006897biological_processendocytosis
G0006911biological_processphagocytosis, engulfment
G0006954biological_processinflammatory response
G0006972biological_processhyperosmotic response
G0007010biological_processcytoskeleton organization
G0007015biological_processactin filament organization
G0007155biological_processcell adhesion
G0007160biological_processcell-matrix adhesion
G0007163biological_processestablishment or maintenance of cell polarity
G0007167biological_processenzyme-linked receptor protein signaling pathway
G0007186biological_processG protein-coupled receptor signaling pathway
G0007264biological_processsmall GTPase-mediated signal transduction
G0007411biological_processaxon guidance
G0008045biological_processmotor neuron axon guidance
G0008360biological_processregulation of cell shape
G0009611biological_processresponse to wounding
G0009653biological_processanatomical structure morphogenesis
G0010310biological_processregulation of hydrogen peroxide metabolic process
G0010591biological_processregulation of lamellipodium assembly
G0010592biological_processpositive regulation of lamellipodium assembly
G0010595biological_processpositive regulation of endothelial cell migration
G0010762biological_processregulation of fibroblast migration
G0010764biological_processnegative regulation of fibroblast migration
G0010810biological_processregulation of cell-substrate adhesion
G0010811biological_processpositive regulation of cell-substrate adhesion
G0014041biological_processregulation of neuron maturation
G0016020cellular_componentmembrane
G0016358biological_processdendrite development
G0016477biological_processcell migration
G0016601biological_processRac protein signal transduction
G0016787molecular_functionhydrolase activity
G0019899molecular_functionenzyme binding
G0019901molecular_functionprotein kinase binding
G0021799biological_processcerebral cortex radially oriented cell migration
G0021831biological_processembryonic olfactory bulb interneuron precursor migration
G0021894biological_processcerebral cortex GABAergic interneuron development
G0022604biological_processregulation of cell morphogenesis
G0030027cellular_componentlamellipodium
G0030031biological_processcell projection assembly
G0030032biological_processlamellipodium assembly
G0030036biological_processactin cytoskeleton organization
G0030041biological_processactin filament polymerization
G0030334biological_processregulation of cell migration
G0030425cellular_componentdendrite
G0030667cellular_componentsecretory granule membrane
G0030672cellular_componentsynaptic vesicle membrane
G0030742molecular_functionGTP-dependent protein binding
G0030838biological_processpositive regulation of actin filament polymerization
G0030865biological_processcortical cytoskeleton organization
G0030900biological_processforebrain development
G0031116biological_processpositive regulation of microtubule polymerization
G0031410cellular_componentcytoplasmic vesicle
G0031529biological_processruffle organization
G0031901cellular_componentearly endosome membrane
G0031996molecular_functionthioesterase binding
G0032496biological_processresponse to lipopolysaccharide
G0032587cellular_componentruffle membrane
G0032707biological_processnegative regulation of interleukin-23 production
G0032956biological_processregulation of actin cytoskeleton organization
G0034446biological_processsubstrate adhesion-dependent cell spreading
G0035025biological_processpositive regulation of Rho protein signal transduction
G0035556biological_processintracellular signal transduction
G0035567biological_processnon-canonical Wnt signaling pathway
G0035774biological_processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
G0036464cellular_componentcytoplasmic ribonucleoprotein granule
G0042470cellular_componentmelanosome
G0042554biological_processsuperoxide anion generation
G0042734cellular_componentpresynaptic membrane
G0042995cellular_componentcell projection
G0043020cellular_componentNADPH oxidase complex
G0043131biological_processerythrocyte enucleation
G0043652biological_processengulfment of apoptotic cell
G0044877molecular_functionprotein-containing complex binding
G0045202cellular_componentsynapse
G0045211cellular_componentpostsynaptic membrane
G0045216biological_processcell-cell junction organization
G0045428biological_processregulation of nitric oxide biosynthetic process
G0045730biological_processrespiratory burst
G0046425biological_processregulation of receptor signaling pathway via JAK-STAT
G0048012biological_processhepatocyte growth factor receptor signaling pathway
G0048168biological_processregulation of neuronal synaptic plasticity
G0048261biological_processnegative regulation of receptor-mediated endocytosis
G0048532biological_processanatomical structure arrangement
G0048812biological_processneuron projection morphogenesis
G0048813biological_processdendrite morphogenesis
G0048870biological_processcell motility
G0048873biological_processhomeostasis of number of cells within a tissue
G0051022molecular_functionRho GDP-dissociation inhibitor binding
G0051492biological_processregulation of stress fiber assembly
G0051496biological_processpositive regulation of stress fiber assembly
G0051668biological_processlocalization within membrane
G0051894biological_processpositive regulation of focal adhesion assembly
G0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
G0051932biological_processsynaptic transmission, GABAergic
G0055038cellular_componentrecycling endosome membrane
G0060071biological_processWnt signaling pathway, planar cell polarity pathway
G0060091cellular_componentkinocilium
G0060263biological_processregulation of respiratory burst
G0060326biological_processcell chemotaxis
G0060999biological_processpositive regulation of dendritic spine development
G0061344biological_processregulation of cell adhesion involved in heart morphogenesis
G0070062cellular_componentextracellular exosome
G0070376biological_processregulation of ERK5 cascade
G0071526biological_processsemaphorin-plexin signaling pathway
G0071542biological_processdopaminergic neuron differentiation
G0072659biological_processprotein localization to plasma membrane
G0086098biological_processangiotensin-activated signaling pathway involved in heart process
G0090023biological_processpositive regulation of neutrophil chemotaxis
G0090103biological_processcochlea morphogenesis
G0097178biological_processruffle assembly
G0098794cellular_componentpostsynapse
G0098978cellular_componentglutamatergic synapse
G0101003cellular_componentficolin-1-rich granule membrane
G0150052biological_processregulation of postsynapse assembly
G1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
G1900029biological_processpositive regulation of ruffle assembly
G1900242biological_processregulation of synaptic vesicle endocytosis
G1902622biological_processregulation of neutrophil migration
G1903348biological_processpositive regulation of bicellular tight junction assembly
G1904395biological_processpositive regulation of skeletal muscle acetylcholine-gated channel clustering
G1904936biological_processinterneuron migration
G1904948biological_processmidbrain dopaminergic neuron differentiation
G2000386biological_processpositive regulation of ovarian follicle development
G2001222biological_processregulation of neuron migration
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues122
DetailsDomain: {"description":"SH3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00192","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues368
DetailsDomain: {"description":"C2 DOCK-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00983","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues822
DetailsDomain: {"description":"DOCKER","evidences":[{"source":"PROSITE-ProRule","id":"PRU00984","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues4
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues24
DetailsMotif: {"description":"Effector region","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"38332367","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8Q0N","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues14
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"11090627","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38332367","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38355798","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1E96","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WKP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WKQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WKR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Q0N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WEJ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues14
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"11090627","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38332367","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1E96","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WKP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WKQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WKR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Q0N","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"11090627","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1E96","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WKP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WKQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WKR","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"38355798","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8WEJ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues2
DetailsModified residue: {"description":"(Microbial infection) O-AMP-tyrosine; by Haemophilus IbpA; alternate","evidences":[{"source":"PubMed","id":"19362538","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues2
DetailsModified residue: {"description":"(Microbial infection) O-AMP-threonine; by Vibrio VopS","evidences":[{"source":"PubMed","id":"19039103","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues2
DetailsGlycosylation: {"description":"(Microbial infection) O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230; alternate","evidences":[{"source":"PubMed","id":"24141704","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues2
DetailsGlycosylation: {"description":"(Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB, and by P.sordellii toxin TcsL; alternate","evidences":[{"source":"PubMed","id":"19744486","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24905543","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7775453","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7777059","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"18093184","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38332367","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"23512198","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues242
DetailsDomain: {"description":"PH"}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues14
DetailsMotif: {"description":"SH3-binding"}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues6
DetailsModified residue: {"description":"Phosphotyrosine; by HCK","evidences":[{"source":"PubMed","id":"15952790","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues173
DetailsDomain: {"description":"ELMO","evidences":[{"source":"PROSITE-ProRule","id":"PRU00664","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q8BPU7","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues10
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P61586","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues11
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P62820","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI26
Number of Residues1
DetailsModified residue: {"description":"ADP-ribosylasparagine; by botulinum toxin","evidences":[{"source":"UniProtKB","id":"P61586","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI27
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI28
Number of Residues1
DetailsGlycosylation: {"description":"(Microbial infection) O-linked (Glc) threonine; by C.difficile toxin TcdB; alternate","evidences":[{"source":"PubMed","id":"24905543","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

238582

PDB entries from 2025-07-09

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