8ZHK

SARS-CoV-2 spike trimer (6P) in complex with three H18 Fabs, head-to-head aggregate (C3 symmetry)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, G, H...	Spike glycoprotein,Fibritin,Expression Tag	polymer	1278	141253.9	6	UniProt (P0DTC2) UniProt (A0A346FJN8) In PDB	Severe acute respiratory syndrome coronavirus 2	S glycoprotein,E2,Peplomer protein,Phage neck whiskers protein
2	D, F, K, L, O...	Light chain of H18 Fab	polymer	243	25768.5	6		Homo sapiens (human)
3	E, J, M, N, P...	Heavy chain of H18 Fab	polymer	243	25868.3	6		Homo sapiens (human)
4	a, b, c, d, e...	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	24	In PDB GlyTouCan (G42666HT)
5	A, G, I, B, H...	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	66	Chemie (NAG)

Sequence modifications

A, B, C, G, H, I: 11 - 1208 (UniProt: P0DTC2)

PDB	External Database	Details
Gly 682	Arg 682	conflict
Ser 683	Arg 683	conflict
Ser 685	Arg 685	conflict
Pro 817	Phe 817	conflict
Pro 892	Ala 892	conflict
Pro 899	Ala 899	conflict
Pro 942	Ala 942	conflict
Pro 986	Lys 986	variant
Pro 987	Val 987	variant
Gly 1209	-	linker
Ser 1210	-	linker

A, B, C, G, H, I: 1211 - 1237 (UniProt: A0A346FJN8)
A, B, C, G, H, I: 1238 - 1288 (PDB: 8ZHK)

Contents of the asymmetric unit

Polymers	Number of chains	18
	Total formula weight	1157344.0
Branched	Number of molecules	24
	Total formula weight	10185.6
Non-Polymers*	Number of molecules	66
	Total formula weight	14599.7
All*	Total formula weight	1182129.3

*Water molecules are not included.