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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8ZHK

SARS-CoV-2 spike trimer (6P) in complex with three H18 Fabs, head-to-head aggregate (C3 symmetry)

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YSCQVTH

Chain	Residue	Details
D	TYR202-HIS208
E	TYR201-HIS207

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	SITE: Cleavage; by host furin => ECO:0000255\|HAMAP-Rule:MF_04099, ECO:0000269\|PubMed:32142651, ECO:0000269\|PubMed:32362314, ECO:0000269\|PubMed:32703818, ECO:0000269\|PubMed:34159616

Chain	Residue	Details
A	SER685
B	SER685
C	SER685
G	SER685
H	SER685
I	SER685

site_id	SWS_FT_FI2
Number of Residues	6
Details	SITE: Cleavage; by host TMPRSS2 or CTSL => ECO:0000255\|HAMAP-Rule:MF_04099, ECO:0000269\|PubMed:32703818, ECO:0000269\|PubMed:34159616

Chain	Residue	Details
A	ARG815
B	ARG815
C	ARG815
G	ARG815
H	ARG815
I	ARG815

site_id	SWS_FT_FI3
Number of Residues	18
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255\|HAMAP-Rule:MF_04099, ECO:0000269\|PubMed:32366695, ECO:0000269\|PubMed:32979942

Chain	Residue	Details
A	ASN17
G	ASN17
G	ASN1158
G	ASN1173
H	ASN17
H	ASN1158
H	ASN1173
I	ASN17
I	ASN1158
I	ASN1173
A	ASN1158
A	ASN1173
B	ASN17
B	ASN1158
B	ASN1173
C	ASN17
C	ASN1158
C	ASN1173

site_id	SWS_FT_FI4
Number of Residues	30
Details	CARBOHYD: N-linked (GlcNAc...) (hybrid) asparagine; by host => ECO:0000255\|HAMAP-Rule:MF_04099, ECO:0000269\|PubMed:32155444, ECO:0000269\|PubMed:32363391, ECO:0000269\|PubMed:32366695, ECO:0000269\|PubMed:32979942

Chain	Residue	Details
A	ASN61
B	ASN1074
C	ASN61
C	ASN122
C	ASN717
C	ASN801
C	ASN1074
G	ASN61
G	ASN122
G	ASN717
G	ASN801
A	ASN122
G	ASN1074
H	ASN61
H	ASN122
H	ASN717
H	ASN801
H	ASN1074
I	ASN61
I	ASN122
I	ASN717
I	ASN801
A	ASN717
I	ASN1074
A	ASN801
A	ASN1074
B	ASN61
B	ASN122
B	ASN717
B	ASN801

site_id	SWS_FT_FI5
Number of Residues	18
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255\|HAMAP-Rule:MF_04099, ECO:0000269\|PubMed:32363391, ECO:0000269\|PubMed:32366695, ECO:0000269\|PubMed:32979942

Chain	Residue	Details
A	ASN74
G	ASN74
G	ASN149
G	ASN1194
H	ASN74
H	ASN149
H	ASN1194
I	ASN74
I	ASN149
I	ASN1194
A	ASN149
A	ASN1194
B	ASN74
B	ASN149
B	ASN1194
C	ASN74
C	ASN149
C	ASN1194

site_id	SWS_FT_FI6
Number of Residues	42
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255\|HAMAP-Rule:MF_04099, ECO:0000269\|PubMed:32155444, ECO:0000269\|PubMed:32363391, ECO:0000269\|PubMed:32366695, ECO:0000269\|PubMed:32979942

Chain	Residue	Details
A	ASN165
B	ASN331
B	ASN343
B	ASN616
B	ASN657
B	ASN1098
C	ASN165
C	ASN282
C	ASN331
C	ASN343
C	ASN616
A	ASN282
C	ASN657
C	ASN1098
G	ASN165
G	ASN282
G	ASN331
G	ASN343
G	ASN616
G	ASN657
G	ASN1098
H	ASN165
A	ASN331
H	ASN282
H	ASN331
H	ASN343
H	ASN616
H	ASN657
H	ASN1098
I	ASN165
I	ASN282
I	ASN331
I	ASN343
A	ASN343
I	ASN616
I	ASN657
I	ASN1098
A	ASN616
A	ASN657
A	ASN1098
B	ASN165
B	ASN282

site_id	SWS_FT_FI7
Number of Residues	12
Details	CARBOHYD: N-linked (GlcNAc...) (high mannose) asparagine; by host => ECO:0000255\|HAMAP-Rule:MF_04099, ECO:0000269\|PubMed:32155444, ECO:0000269\|PubMed:32363391, ECO:0000269\|PubMed:32366695, ECO:0000269\|PubMed:32979942

Chain	Residue	Details
A	ASN234
H	ASN709
I	ASN234
I	ASN709
A	ASN709
B	ASN234
B	ASN709
C	ASN234
C	ASN709
G	ASN234
G	ASN709
H	ASN234

site_id	SWS_FT_FI8
Number of Residues	6
Details	CARBOHYD: O-linked (GalNAc) threonine; by host => ECO:0000269\|PubMed:32363391

Chain	Residue	Details
A	THR323
B	THR323
C	THR323
G	THR323
H	THR323
I	THR323

site_id	SWS_FT_FI9
Number of Residues	6
Details	CARBOHYD: O-linked (HexNAc...) serine; by host => ECO:0000269\|PubMed:32363391

Chain	Residue	Details
A	SER325
B	SER325
C	SER325
G	SER325
H	SER325
I	SER325

site_id	SWS_FT_FI10
Number of Residues	6
Details	CARBOHYD: N-linked (GlcNAc...) (hybrid) asparagine; by host => ECO:0000255\|HAMAP-Rule:MF_04099, ECO:0000269\|PubMed:32155444, ECO:0000269\|PubMed:32366695, ECO:0000269\|PubMed:32979942

Chain	Residue	Details
A	ASN603
B	ASN603
C	ASN603
G	ASN603
H	ASN603
I	ASN603

site_id	SWS_FT_FI11
Number of Residues	12
Details	CARBOHYD: O-linked (GlcNAc...) threonine; by host GALNT1 => ECO:0000269\|PubMed:34732583

Chain	Residue	Details
A	THR676
H	THR678
I	THR676
I	THR678
A	THR678
B	THR676
B	THR678
C	THR676
C	THR678
G	THR676
G	THR678
H	THR676

site_id	SWS_FT_FI12
Number of Residues	6
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255\|HAMAP-Rule:MF_04099, ECO:0000269\|PubMed:32155444, ECO:0000269\|PubMed:32366695, ECO:0000269\|PubMed:32979942

Chain	Residue	Details
A	ASN1134
B	ASN1134
C	ASN1134
G	ASN1134
H	ASN1134
I	ASN1134

224004

PDB entries from 2024-08-21

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