8ZH8
Human GPR103 -Gq complex bound to QRFP26
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | R | Pyroglutamylated RF-amide peptide receptor | polymer | 402 | 45652.0 | 1 | UniProt (Q96P65) Pfam (PF00001) In PDB | Homo sapiens (human) | AQ27,G-protein coupled receptor 103,Orexigenic neuropeptide QRFP receptor,SP9155 |
2 | N | nanobody Nb35 | polymer | 137 | 15015.7 | 1 | Lama glama | ||
3 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 351 | 38744.4 | 1 | UniProt (P54311) Pfam (PF00400) In PDB | Rattus norvegicus (Norway rat) | Transducin beta chain 1 |
4 | G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 68 | 7547.7 | 1 | UniProt (P63212) Pfam (PF00631) In PDB | Bos taurus (cattle) | G gamma-I |
5 | A | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2,Guanine nucleotide-binding protein G(i) subunit alpha-2,Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas | polymer | 326 | 36573.5 | 1 | UniProt (P59768) UniProt (P04899) UniProt (Q5JWF2) Pfam (PF00631) Pfam (PF00503) In PDB | Homo sapiens (human) | G gamma-I,Adenylate cyclase-inhibiting G alpha protein,Adenylate cyclase-stimulating G alpha protein,Extra large alphas protein,XLalphas |
6 | S | scFv16 | polymer | 260 | 27720.8 | 1 | Mus musculus | ||
7 | Q | QRF-amide | polymer | 27 | 2835.2 | 1 | UniProt (P83859) In PDB | Homo sapiens | Neuropeptide RF-amide,Pyroglutamylated arginine-phenylalanine-amide peptide |
Sequence modifications
R: 2 - 366 (UniProt: Q96P65)
B: 2 - 340 (UniProt: P54311)
G: 1 - 67 (UniProt: P63212)
A: -79 - -9 (UniProt: P59768)
A: 1 - 57 (UniProt: P04899)
A: 66 - 246 (UniProt: Q5JWF2)
Q: 1 - 26 (UniProt: P83859)
PDB | External Database | Details |
---|---|---|
Met -22 | - | initiating methionine |
Lys -21 | - | expression tag |
Thr -20 | - | expression tag |
Ile -19 | - | expression tag |
Ile -18 | - | expression tag |
Ala -17 | - | expression tag |
Leu -16 | - | expression tag |
Ser -15 | - | expression tag |
Tyr -14 | - | expression tag |
Ile -13 | - | expression tag |
Phe -12 | - | expression tag |
Cys -11 | - | expression tag |
Leu -10 | - | expression tag |
Val -9 | - | expression tag |
Phe -8 | - | expression tag |
Ala -7 | - | expression tag |
Asp -6 | - | expression tag |
Tyr -5 | - | expression tag |
Lys -4 | - | expression tag |
Asp -3 | - | expression tag |
Asp -2 | - | expression tag |
Asp -1 | - | expression tag |
Asp 0 | - | expression tag |
Lys 1 | - | expression tag |
Ser 367 | - | expression tag |
Gly 368 | - | expression tag |
Gly 369 | - | expression tag |
Gly 370 | - | expression tag |
Gly 371 | - | expression tag |
Ser 372 | - | expression tag |
Gly 373 | - | expression tag |
Gly 374 | - | expression tag |
Ser 375 | - | expression tag |
Ser 376 | - | expression tag |
Ser 377 | - | expression tag |
Gly 378 | - | expression tag |
Gly 379 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met -10 | - | expression tag |
His -9 | - | expression tag |
His -8 | - | expression tag |
His -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
Gly -3 | - | expression tag |
Ser -2 | - | expression tag |
Leu -1 | - | expression tag |
Leu 0 | - | expression tag |
Gln 1 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Ser 68 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly -8 | - | linker |
Ser -7 | - | linker |
Ala -6 | - | linker |
Gly -5 | - | linker |
Ser -4 | - | linker |
Ala -3 | - | linker |
Gly -2 | - | linker |
Ser -1 | - | linker |
Ala 0 | - | linker |
PDB | External Database | Details |
---|---|---|
Ser 3 | Cys 3 | engineered mutation |
Arg 31 | Ala 31 | engineered mutation |
Thr 33 | Glu 33 | engineered mutation |
Leu 34 | Val 34 | engineered mutation |
Arg 35 | Lys 35 | engineered mutation |
Asp 42 | Gly 42 | engineered mutation |
Asn 43 | Glu 43 | engineered mutation |
Arg 54 | Lys 54 | engineered mutation |
Leu 56 | Ile 56 | engineered mutation |
Gly 58 | - | linker |
Gly 59 | - | linker |
Ser 60 | - | linker |
Gly 61 | - | linker |
Gly 62 | - | linker |
Ser 63 | - | linker |
Gly 64 | - | linker |
Gly 65 | - | linker |
PDB | External Database | Details |
---|---|---|
Asp 111 | Ala 892 | engineered mutation |
Asp 114 | Ser 895 | engineered mutation |
- | Asn 897 | deletion |
- | Met 898 | deletion |
- | Val 899 | deletion |
- | Ile 900 | deletion |
- | Arg 901 | deletion |
- | Glu 902 | deletion |
- | Asp 903 | deletion |
- | Asn 904 | deletion |
- | Gln 905 | deletion |
- | Thr 906 | deletion |
Asp 124 | Leu 915 | engineered mutation |
Lys 195 | Asp 986 | engineered mutation |
Val 198 | Leu 989 | engineered mutation |
Asp 199 | Arg 990 | engineered mutation |
Ile 210 | Tyr 1001 | engineered mutation |
Ala 224 | Ile 1015 | engineered mutation |
Ile 227 | Val 1018 | engineered mutation |
Lys 232 | Arg 1023 | engineered mutation |
Leu 236 | Gln 1027 | engineered mutation |
Gln 237 | Arg 1028 | engineered mutation |
Asn 239 | His 1030 | engineered mutation |
Glu 242 | Gln 1033 | engineered mutation |
Asn 244 | Glu 1035 | engineered mutation |
Val 246 | Leu 1037 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Nh2 27 | - | amidation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 7 |
Total formula weight | 174089.3 | |
All* | Total formula weight | 174089.3 |