8Z8L

structure of IL-4Ra in complex with an nanobody 4E9

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (B)	Interleukin-4 receptor subunit alpha	polymer	214	24622.5	1	UniProt (P24394) Pfam (PF09238)	Homo sapiens (human)	IL-4 receptor subunit alpha,IL-4R subunit alpha,IL-4R-alpha,IL-4RA
2	B (A)	nanobody dAb1	polymer	124	13520.0	1		Vicugna pacos
3	C (C)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
4	D (B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)

Sequence modifications

B: 1 - 207 (UniProt: P24394)

PDB	External Database	Details
Ala 182	Cys 207	engineered mutation
His 208	-	expression tag
His 209	-	expression tag
His 210	-	expression tag
His 211	-	expression tag
His 212	-	expression tag
His 213	-	expression tag
Ala 214	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	38142.5
Branched	Number of molecules	1
	Total formula weight	424.4
Non-Polymers*	Number of molecules	1
	Total formula weight	221.2
All*	Total formula weight	38788.1

*Water molecules are not included.