8Z57
Crystal structure of human Q140L-SIRT5 in complex with succinylated Prx1 fragment and ADP ribose
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | NAD-dependent protein deacylase sirtuin-5, mitochondrial | polymer | 274 | 29999.2 | 1 | UniProt (Q9NXA8) Pfam (PF02146) | Homo sapiens (human) | Regulatory protein SIR2 homolog 5,SIR2-like protein 5 |
| 2 | B (B) | Peroxiredoxin-1 fragment | polymer | 9 | 1246.4 | 1 | UniProt (Q06830) | Homo sapiens | Prx1 fragment |
| 3 | C (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 4 | D (A) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
| 5 | E, F (A, B) | water | water | 18.0 | 99 | Chemie (HOH) |
Sequence modifications
A: 36 - 302 (UniProt: Q9NXA8)
| PDB | External Database | Details |
|---|---|---|
| Met 29 | - | initiating methionine |
| His 30 | - | expression tag |
| His 31 | - | expression tag |
| His 32 | - | expression tag |
| His 33 | - | expression tag |
| His 34 | - | expression tag |
| His 35 | - | expression tag |
| Leu 140 | Gln 140 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 31245.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 492.6 | |
| All* | Total formula weight | 31738.2 |
