8Z54

Crystal structure of human SIRT5 in complex with succinylated Prx1 fragment

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	NAD-dependent protein deacylase sirtuin-5, mitochondrial	polymer	274	30014.2	1	UniProt (Q9NXA8) In PDB	Homo sapiens (human)	Regulatory protein SIR2 homolog 5,SIR2-like protein 5
2	B	Peroxiredoxin-1 fragment	polymer	9	1246.4	1	UniProt (Q06830) In PDB	Homo sapiens	Prx1 fragment
3	A	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
4	A	DIMETHYL SULFOXIDE	non-polymer		78.1	2	Chemie (DMS)
5		water	water		18.0	227	Chemie (HOH)

Sequence modifications

A: 36 - 302 (UniProt: Q9NXA8)

PDB	External Database	Details
Met 29	-	initiating methionine
His 30	-	expression tag
His 31	-	expression tag
His 32	-	expression tag
His 33	-	expression tag
His 34	-	expression tag
His 35	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	31260.6
Non-Polymers*	Number of molecules	3
	Total formula weight	221.7
All*	Total formula weight	31482.2

*Water molecules are not included.