8YYW
Cryo-EM structure of OXGR1 bound to alpha-ketoglutarate and Gq proteins
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | ScFv16 | polymer | 247 | 26337.3 | 1 | Vicugna pacos | ||
| 2 | B (C) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 339 | 37285.7 | 1 | UniProt (P62873) Pfam (PF00400) | Homo sapiens (human) | Transducin beta chain 1 |
| 3 | C (D) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 57 | 6289.2 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 4 | D (E) | 2-oxoglutarate receptor 1 | polymer | 337 | 38284.0 | 1 | UniProt (Q96P68) Pfam (PF00001) | Homo sapiens (human) | Alpha-ketoglutarate receptor 1,G-protein coupled receptor 80,G-protein coupled receptor 99,P2Y purinoceptor 15,P2Y15,P2Y-like GPCR,P2Y-like nucleotide receptor |
| 5 | E (F) | Guanine nucleotide-binding protein G(i) subunit alpha-1,Guanine nucleotide-binding protein G(q) subunit alpha | polymer | 354 | 40555.2 | 1 | UniProt (P63096) UniProt (P50148) Pfam (PF00503) | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein,Guanine nucleotide-binding protein alpha-q |
| 6 | F, G (E) | 2-OXOGLUTARIC ACID | non-polymer | 146.1 | 2 | Chemie (AKG) |
Sequence modifications
F: 1 - 329 (UniProt: P63096)
F: 330 - 354 (UniProt: P50148)
| PDB | External Database | Details |
|---|---|---|
| Ala 203 | Gly 203 | engineered mutation |
| Ser 326 | Ala 326 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 148751.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 292.2 | |
| All* | Total formula weight | 149043.7 |
