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8YYW

Cryo-EM structure of OXGR1 bound to alpha-ketoglutarate and Gq proteins

Functional Information from GO Data
ChainGOidnamespacecontents
C0001750cellular_componentphotoreceptor outer segment
C0003924molecular_functionGTPase activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005765cellular_componentlysosomal membrane
C0005829cellular_componentcytosol
C0005834cellular_componentheterotrimeric G-protein complex
C0005886cellular_componentplasma membrane
C0007165biological_processsignal transduction
C0007186biological_processG protein-coupled receptor signaling pathway
C0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
C0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
C0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
C0007265biological_processRas protein signal transduction
C0008283biological_processcell population proliferation
C0016020cellular_componentmembrane
C0030159molecular_functionsignaling receptor complex adaptor activity
C0044877molecular_functionprotein-containing complex binding
C0045202cellular_componentsynapse
C0050909biological_processsensory perception of taste
C0051020molecular_functionGTPase binding
C0060041biological_processretina development in camera-type eye
C0070062cellular_componentextracellular exosome
C0071380biological_processcellular response to prostaglandin E stimulus
C0071870biological_processcellular response to catecholamine stimulus
C0097381cellular_componentphotoreceptor disc membrane
C1903561cellular_componentextracellular vesicle
E0002376biological_processimmune system process
E0004930molecular_functionG protein-coupled receptor activity
E0005886cellular_componentplasma membrane
E0007165biological_processsignal transduction
E0007186biological_processG protein-coupled receptor signaling pathway
E0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
E0007208biological_processphospholipase C-activating serotonin receptor signaling pathway
E0016020cellular_componentmembrane
E0038023molecular_functionsignaling receptor activity
E0045087biological_processinnate immune response
F0000166molecular_functionnucleotide binding
F0000287molecular_functionmagnesium ion binding
F0001664molecular_functionG protein-coupled receptor binding
F0003924molecular_functionGTPase activity
F0003925molecular_functionG protein activity
F0005515molecular_functionprotein binding
F0005525molecular_functionGTP binding
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005730cellular_componentnucleolus
F0005737cellular_componentcytoplasm
F0005765cellular_componentlysosomal membrane
F0005794cellular_componentGolgi apparatus
F0005813cellular_componentcentrosome
F0005829cellular_componentcytosol
F0005834cellular_componentheterotrimeric G-protein complex
F0005856cellular_componentcytoskeleton
F0005886cellular_componentplasma membrane
F0005938cellular_componentcell cortex
F0007165biological_processsignal transduction
F0007186biological_processG protein-coupled receptor signaling pathway
F0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
F0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
F0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
F0007198biological_processadenylate cyclase-inhibiting serotonin receptor signaling pathway
F0007218biological_processneuropeptide signaling pathway
F0010854molecular_functionadenylate cyclase regulator activity
F0010855molecular_functionadenylate cyclase inhibitor activity
F0016020cellular_componentmembrane
F0016787molecular_functionhydrolase activity
F0019003molecular_functionGDP binding
F0030496cellular_componentmidbody
F0031683molecular_functionG-protein beta/gamma-subunit complex binding
F0031749molecular_functionD2 dopamine receptor binding
F0031821molecular_functionG protein-coupled serotonin receptor binding
F0034451cellular_componentcentriolar satellite
F0034695biological_processresponse to prostaglandin E
F0036064cellular_componentciliary basal body
F0043434biological_processresponse to peptide hormone
F0045542biological_processpositive regulation of cholesterol biosynthetic process
F0046676biological_processnegative regulation of insulin secretion
F0046872molecular_functionmetal ion binding
F0051301biological_processcell division
F0060236biological_processregulation of mitotic spindle organization
F0070062cellular_componentextracellular exosome
F0070098biological_processchemokine-mediated signaling pathway
F0072678biological_processT cell migration
F1901082biological_processpositive regulation of relaxation of smooth muscle
F1904322biological_processcellular response to forskolin
F1904778biological_processpositive regulation of protein localization to cell cortex
Functional Information from PROSITE/UniProt
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
CLEU70-SER84
CILE157-ILE171
CLEU285-ALA299

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:21115486, ECO:0007744|PDB:1KJY, ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q
ChainResidueDetails
FGLU43
FASN269
ETHR173-ILE201
EARG264-TYR284

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:18434541, ECO:0000269|PubMed:22383884, ECO:0007744|PDB:3QE0
ChainResidueDetails
FSER47
FTHR181

site_idSWS_FT_FI3
Number of Residues1
DetailsBINDING: BINDING => ECO:0007744|PDB:1KJY, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:4G5Q
ChainResidueDetails
FSER151
EPRO138-VAL151
EHIS223-LEU242
ESER306-PRO337

site_idSWS_FT_FI4
Number of Residues1
DetailsBINDING: BINDING => ECO:0007744|PDB:1KJY, ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q
ChainResidueDetails
FLEU175

site_idSWS_FT_FI5
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:21115486
ChainResidueDetails
FASP200

site_idSWS_FT_FI6
Number of Residues1
DetailsBINDING: BINDING => ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q
ChainResidueDetails
FSER326

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: ADP-ribosylarginine; by cholera toxin => ECO:0000250
ChainResidueDetails
FARG178

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: Deamidated glutamine; by Photorhabdus PAU_02230 => ECO:0000269|PubMed:24141704
ChainResidueDetails
FGLN204

site_idSWS_FT_FI9
Number of Residues1
DetailsLIPID: N-myristoyl glycine => ECO:0000269|PubMed:20213681, ECO:0000269|PubMed:25255805
ChainResidueDetails
FGLY2

site_idSWS_FT_FI10
Number of Residues1
DetailsLIPID: S-palmitoyl cysteine => ECO:0000250|UniProtKB:P10824
ChainResidueDetails
FCYS3
EASN23
EASN176
EASN179

236620

PDB entries from 2025-05-28

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