8YWA

The structure of IgE receptor binding to IgE

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (H, X)	Immunoglobulin heavy constant epsilon	polymer	577	63525.3	2		Homo sapiens (human)
2	C, D (h, x)	Immunoglobulin kappa constant	polymer	261	27441.4	2		Homo sapiens (human)
3	E (A)	High affinity immunoglobulin epsilon receptor subunit alpha	polymer	267	30892.1	1	UniProt (P12319) Pfam (PF13927) Pfam (PF13895)	Homo sapiens (human)	Fc-epsilon RI-alpha,FcERI,IgE Fc receptor subunit alpha
4	F (B)	High affinity immunoglobulin epsilon receptor subunit beta	polymer	283	30289.5	1	UniProt (Q01362) Pfam (PF04103)	Homo sapiens (human)	FcERI,Fc epsilon receptor I beta-chain,IgE Fc receptor subunit beta,Membrane-spanning 4-domains subfamily A member 2
5	G, H (D, C)	High affinity immunoglobulin epsilon receptor subunit gamma	polymer	86	9676.4	2	UniProt (P30273) Pfam (PF11628) Pfam (PF02189)	Homo sapiens (human)	Fc receptor gamma-chain,FcRgamma,Fc-epsilon RI-gamma,IgE Fc receptor subunit gamma,FceRI gamma
6	I, J, K, L, M... (H, X, A)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	9	Chemie (NAG)

Sequence modifications

A: 26 - 257 (UniProt: P12319)

PDB	External Database	Details
Met 4	-	initiating methionine
Asp 5	-	expression tag
Met 6	-	expression tag
Arg 7	-	expression tag
Val 8	-	expression tag
Pro 9	-	expression tag
Ala 10	-	expression tag
Gln 11	-	expression tag
Leu 12	-	expression tag
Leu 13	-	expression tag
Gly 14	-	expression tag
Leu 15	-	expression tag
Leu 16	-	expression tag
Leu 17	-	expression tag
Leu 18	-	expression tag
Trp 19	-	expression tag
Leu 20	-	expression tag
Ser 21	-	expression tag
Gly 22	-	expression tag
Ala 23	-	expression tag
Arg 24	-	expression tag
Cys 25	-	expression tag
Gly 258	-	expression tag
Gly 259	-	expression tag
Gly 260	-	expression tag
Ser 261	-	expression tag
Met 262	-	expression tag
Asp 263	-	expression tag
Tyr 264	-	expression tag
Lys 265	-	expression tag
Asp 266	-	expression tag
Asp 267	-	expression tag
Asp 268	-	expression tag
Asp 269	-	expression tag
Lys 270	-	expression tag

B: -39 - 204 (UniProt: Q01362)

PDB	External Database	Details
Met -78	-	initiating methionine
Gly -77	-	expression tag
Ala -76	-	expression tag
Ser -75	-	expression tag
Ser -74	-	expression tag
Ala -73	-	expression tag
Trp -72	-	expression tag
Ser -71	-	expression tag
His -70	-	expression tag
Pro -69	-	expression tag
Gln -68	-	expression tag
Phe -67	-	expression tag
Glu -66	-	expression tag
Lys -65	-	expression tag
Gly -64	-	expression tag
Gly -63	-	expression tag
Gly -62	-	expression tag
Ser -61	-	expression tag
Gly -60	-	expression tag
Gly -59	-	expression tag
Gly -58	-	expression tag
Ser -57	-	expression tag
Gly -56	-	expression tag
Gly -55	-	expression tag
Ser -54	-	expression tag
Ala -53	-	expression tag
Trp -52	-	expression tag
Ser -51	-	expression tag
His -50	-	expression tag
Pro -49	-	expression tag
Gln -48	-	expression tag
Phe -47	-	expression tag
Glu -46	-	expression tag
Lys -45	-	expression tag
Gly -44	-	expression tag
Ser -43	-	expression tag
Ala -42	-	expression tag
Ala -41	-	expression tag
Ala -40	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	262467.7
Non-Polymers*	Number of molecules	9
	Total formula weight	1990.9
All*	Total formula weight	264458.6

*Water molecules are not included.