8YWA
The structure of IgE receptor binding to IgE
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0007166 | biological_process | cell surface receptor signaling pathway |
| A | 0009897 | cellular_component | external side of plasma membrane |
| A | 0009986 | cellular_component | cell surface |
| A | 0016064 | biological_process | immunoglobulin mediated immune response |
| A | 0016068 | biological_process | type I hypersensitivity |
| A | 0019768 | molecular_function | high-affinity IgE receptor activity |
| A | 0019863 | molecular_function | IgE binding |
| A | 0038095 | biological_process | Fc-epsilon receptor signaling pathway |
| A | 0042092 | biological_process | type 2 immune response |
| A | 0043303 | biological_process | mast cell degranulation |
| A | 0043308 | biological_process | eosinophil degranulation |
| B | 0005515 | molecular_function | protein binding |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006955 | biological_process | immune response |
| B | 0007166 | biological_process | cell surface receptor signaling pathway |
| B | 0009897 | cellular_component | external side of plasma membrane |
| B | 0016020 | cellular_component | membrane |
| B | 0019863 | molecular_function | IgE binding |
| B | 0032998 | cellular_component | Fc-epsilon receptor I complex |
| C | 0004888 | molecular_function | transmembrane signaling receptor activity |
| C | 0007166 | biological_process | cell surface receptor signaling pathway |
| C | 0016020 | cellular_component | membrane |
| C | 0019767 | molecular_function | IgE receptor activity |
| C | 0032998 | cellular_component | Fc-epsilon receptor I complex |
| D | 0004888 | molecular_function | transmembrane signaling receptor activity |
| D | 0007166 | biological_process | cell surface receptor signaling pathway |
| D | 0016020 | cellular_component | membrane |
| D | 0019767 | molecular_function | IgE receptor activity |
| D | 0032998 | cellular_component | Fc-epsilon receptor I complex |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. FTCRVAH |
| Chain | Residue | Details |
| H | PHE199-HIS205 | |
| H | TYR413-HIS419 | |
| H | PHE519-HIS525 | |
| h | TYR196-HIS202 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 134 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 80 |
| Details | Domain: {"description":"Ig-like 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 82 |
| Details | Domain: {"description":"Ig-like 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"10917520","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11531339","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9875849","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11531339","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 46 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 12 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
